51cg

People

Professor Claude Wischik

Professor Claude Wischik
Professor Claude Wischik
Professor Claude Wischik

Chair in Mental Health (Clin)

51cg
Email Address
c.m.wischik@abdn.ac.uk
Office Address

TauRx Therapeutics Ltd

1st Floor, Sir Moir Lockhead Building

395 King Street

Aberdeen

AB24 5RP

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

Page 2 of 12 Results 11 to 20 of 115

  • FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning

    Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.
    Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

    Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
    FEBS Journal, vol. 292, no. 10, pp. 2602-2623
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

    Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
    Working Papers: Preprint Papers
    • [ONLINE] DOI:

  • Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease

    Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.
    Scientific Reports, vol. 15, 1671
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

    Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
    Brain Research Bulletin, vol. 220, 111172
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

    Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
    Alzheimer's Research & Therapy, vol. 16, 209
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine

    Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.
    Cellular Signalling, vol. 121, 111269
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors

    Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.
    Brain Research Bulletin, vol. 212, 110955
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

    Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.
    Translational neurodegeneration, vol. 13, 25
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy

    Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.
    European Journal of Pharmacology, vol. 970, 176505
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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