51cg

People

Professor Claude Wischik

Professor Claude Wischik
Professor Claude Wischik
Professor Claude Wischik

Chair in Mental Health (Clin)

51cg
Email Address
c.m.wischik@abdn.ac.uk
Office Address

TauRx Therapeutics Ltd

1st Floor, Sir Moir Lockhead Building

395 King Street

Aberdeen

AB24 5RP

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

Page 5 of 12 Results 41 to 50 of 115

  • Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks

    Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.
    Cells, vol. 10, no. 8, 2162
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

    Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Cells, vol. 10, no. 3, 703
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

    Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.
    Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Adaptive neurological testing method

    Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.
    Patents: Patents

  • Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

    Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.
    International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

    Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Frontiers in Neurology, vol. 11, 590754
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

    Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

    Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.
    Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

    Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
    Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
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