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People

Dr David Gamble

Dr David Gamble
Dr David Gamble
Dr David Gamble

MPharm, MBBS, MRCP(UK), PhD

SCREDS Clinical Lecturer

51cg
School/Department
School of Medicine, Medical Sciences and Nutrition



Biography

I am an Academic Cardiology Registrar and Clinical Lecturer in Cardiology at the 51cg, combining specialist clinical training with translational cardiovascular research. I hold an MBBS medical degree, an MPharm pharmacy masters degree, and a PhD in Cardiovascular Medicine. I graduated from University College London (UCL) Medical School, having previously completed a Master of Pharmacy degree at the University of Nottingham.

My interests include cardiac electrophysiology, cardiovascular disease in women and cardiac pharmacology.

A major focus of my work is improving cardiovascular care for women. I have published randomised clinical trials on behavioural modifications in takotsubo cardiomyopathy, myocardial energetic impairment post anthracycline chemotherapy and on hypertensive disorders of pregnancy. 

Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy

Takotsubo cardiomyopathy causes acute left ventricular dysfunction. This multicentre trial randomized 76 patients to 12 weeks of exercise training, cognitive behavioural therapy (CBT), or standard care. Both exercise and CBT improved myocardial energetics, peak oxygen consumption, and 6-minute walk distance compared with standard care, but neither improved global longitudinal strain or heart failure symptoms.

Qualifications

  • PhD Cardiovascular Medicine 
    2025 - 51cg 

    PhD title – Cardiac energetics as a diagnostic and study endpoint in non-ischaemic cardiomyopathies.

  • MBBS BACHELOR OF MEDICINE, BACHELOR OF SURGERY. UNIVERSITY COLLEGE LONDON 
    2015 - University College London 
  • MPharm MASTER OF PHARMACY WITH FIRST CLASS HONOURS - UNIVERSITY OF NOTTINGHAM 
    2008 - University of Nottingham 

     Masters title - Synthesis and biological evaluation of N-methyl-5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2-amine

  • PGCert PGCERT MEDICAL RESEARCH SKILLS - UNIVERSITY OF ABERDEEN 
    2017 - 51cg 

External Memberships

Member of the Royal College of Physicians

Member of the British Society of Echocardiography

Member of the ESC Working Group on Myocardial Function

Latest Publications

  • Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy: A Randomized Controlled Trial

    Gamble, D. T., Ross, J., Khan, H., Cheyne, L., Rudd, A., Srinivasan, J., Horgan, G., Hogg, D., Myint, P. K., Newby, D. E., Williams, C., Gray, S., Dawson, D.
    Circulation. Heart Failure, vol. 19, no. 3, e013229
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy

    Balode, L., Kelly, R., Higgins, D. M., Gamble, D., Dawson, D., Ross, P. J.
    Journal of Cardiovascular Magnetic Resonance, vol. 27, no. 2, 101965
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Takotsubo syndrome: cognitive behavioural therapy, physical training, and brain function recovery in the BREAKOUT trial

    Khan, H., Gamble, D., Rudd, A., Dospinescu, C., Creaney, C., Horgan, G., Holme, A. L., Wilson, H., Newby, D. E., Gray, S., Krishnadas, R., Williams, C., Waiter, G., Dawson, D.
    European Heart Journal, vol. 46, no. 40, pp. 4127-4129
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Kiosk 11R-TA-07 - T1휌 Imaging for Detecting Takotsubo Cardiomyopathy

    Balode, L., Ross, J., Dawson, D., Gamble, D., Kelly, R.
    Journal of Cardiovascular Magnetic Resonance, vol. 26, no. Supplement 1, 100300
    Contributions to Journals: Comments and Debates
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cardiovascular and Noncardiovascular Prescribing and Mortality After Takotsubo: Comparison with Myocardial Infarction and General Population

    Rudd, A., Horgan, G., Khan, H., Gamble, D., McGowan, J., Sood, A., McGeoch, R., Irving, J., Watt, J., Leslie, S., Petrie, M. C., Lang, C. C., Mills, N. L., Newby, D. E., Dawson, D.
    Journal of the American College of Cardiology, vol. 3, no. 2, 100797
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

View My Publications

Prizes and Awards

Dean's prize Aberdeen University

Best research presentation Scottish Cardiac Society 2025

Research

Research Overview

Cardiovascular disease in women, cardiovascular epidemiology and pharmacology.

Research Areas

Biomedical Sciences

  • Supervising
View Research Area

Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy

Takotsubo cardiomyopathy causes acute left ventricular dysfunction. This multicentre trial randomized 76 patients to 12 weeks of exercise training, cognitive behavioural therapy (CBT), or standard care. Both exercise and CBT improved myocardial energetics, peak oxygen consumption, and 6-minute walk distance compared with standard care, but neither improved global longitudinal strain or heart failure symptoms.

Funding and Grants

Tenovus Scotland

British Heart Foundation

Teaching

Courses

Teaching Responsibilities

I believe that excellence in academic medicine is intrinsically linked to excellence in education. Throughout my career, I have been committed to developing as a medical educator alongside my research and clinical practice.

I have designed and delivered a structured twilight teaching programme for final-year medical students and served as a Teaching Fellow at the 51cg Medical School. In this role, I contributed to undergraduate medical and physician associate education through curriculum delivery, student mentorship, assessment design and examination, admissions interviewing, and pastoral support. These responsibilities have provided extensive experience across multiple facets of medical education, including curriculum development, assessment design, quality assurance, and the delivery of both small-group and large-group teaching.

I am also an Advanced Life Support (ALS) instructor, delivering postgraduate resuscitation training to multidisciplinary healthcare professionals. In addition, I contribute to the cardiovascular science curriculum at the 51cg Medical School, teaching undergraduate medical students and helping to integrate contemporary cardiovascular research with clinical practice.

Publications

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  • Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy: A Randomized Controlled Trial

    Gamble, D. T., Ross, J., Khan, H., Cheyne, L., Rudd, A., Srinivasan, J., Horgan, G., Hogg, D., Myint, P. K., Newby, D. E., Williams, C., Gray, S., Dawson, D.
    Circulation. Heart Failure, vol. 19, no. 3, e013229
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A comparison of T1ρ with native T1 and T2 mapping for detecting oedema in Takotsubo cardiomyopathy

    Balode, L., Kelly, R., Higgins, D. M., Gamble, D., Dawson, D., Ross, P. J.
    Journal of Cardiovascular Magnetic Resonance, vol. 27, no. 2, 101965
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Takotsubo syndrome: cognitive behavioural therapy, physical training, and brain function recovery in the BREAKOUT trial

    Khan, H., Gamble, D., Rudd, A., Dospinescu, C., Creaney, C., Horgan, G., Holme, A. L., Wilson, H., Newby, D. E., Gray, S., Krishnadas, R., Williams, C., Waiter, G., Dawson, D.
    European Heart Journal, vol. 46, no. 40, pp. 4127-4129
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Kiosk 11R-TA-07 - T1휌 Imaging for Detecting Takotsubo Cardiomyopathy

    Balode, L., Ross, J., Dawson, D., Gamble, D., Kelly, R.
    Journal of Cardiovascular Magnetic Resonance, vol. 26, no. Supplement 1, 100300
    Contributions to Journals: Comments and Debates
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cardiovascular and Noncardiovascular Prescribing and Mortality After Takotsubo: Comparison with Myocardial Infarction and General Population

    Rudd, A., Horgan, G., Khan, H., Gamble, D., McGowan, J., Sood, A., McGeoch, R., Irving, J., Watt, J., Leslie, S., Petrie, M. C., Lang, C. C., Mills, N. L., Newby, D. E., Dawson, D.
    Journal of the American College of Cardiology, vol. 3, no. 2, 100797
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer

    Gamble, D. T., Ross, J., Khan, H., Unger, A., Cheyne, L., Rudd, A., Saunders, F., Srivanasan, J., Kamya, S., Horgan, G., Hannah, A., Baliga, S., Tocchetti, C. G., Urquhart, G., Linke, W. A., Masannat, Y., Mustafa, A., Fuller, M., Elsberger, B., Sharma, R., Dawson, D.
    Circulation. Cardiovascular imaging, vol. 16, no. 10, pp. 817-826
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Ultrafiltration versus diuretics on prognostic cardiac and renal biomarkers in acute decompensated heart failure: a systematic review and meta-analysis

    Tay, K. L., Osman, A. R., Yeoh, E. E. X., Luangboriboon, J., Lau, J. F., Chan, J. J. A., Yousif, M., Tse, B. Y. H., Horgan, G., Gamble, D., Myint, P. K.
    Journal of Clinical Medicine, vol. 12, no. 8, 2793
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Structural and functional brain changes in acute Takotsubo Syndrome

    Khan, H., Gamble, D., Rudd, A., Mezincescu, A., Abbas, H., Noman, A., Stewart, A., Horgan, G., Krishnadas, R., Williams, C., Waiter, G., Dawson, D.
    JACC. Heart failure, vol. 11, no. 3, pp. 307-317
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications

    Singh, T., Khan, H., Gamble, D. T., Scally, C., Newby, D. E., Dawson, D.
    Circulation, vol. 145, no. 13, pp. 1002-1019
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • An ecological study assessing the relationship between Public Health Policies and Severity of the COVID-19 Pandemic

    Pasdar, Z., Pana, T., Ewers, K. D., Szlachetka, W. A., Perdomo Lampignano, J., Gamble, D., Bhattacharya, S., Carter, B., Myint, P. K.
    Healthcare, vol. 9, no. 9, 1221
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A systematic review of biomarkers in Takotsubo syndrome: A focus on better understanding the pathophysiology

    Khan, H., Gamble, D., Mezincescu, A., Abbas, H., Rudd, A., Dawson, D.
    IJC Heart & Vasculature, vol. 34, 100795
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Country-level determinants of the severity of the first global wave of the COVID-19 pandemic: an ecological study

    Pana, T. A., Bhattacharya, S., Gamble, D. T., Pasdar, Z., Szlachetka, W. A., Perdomo-Lampignano, J. A., Ewers, K. D., McLernon, D. J., Myint, P. K.
    BMJ Open, vol. 11, no. 2, e042034
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Hypertensive disorders of pregnancy (HDP) and the risk of common cancers in women: Evidence from the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population-based study.

    Pasdar, Z., Gamble, D., Myint, P. K., Luben, R. N., Wareham, N. J., Khaw, K. T., Bhattacharya, S.
    Cancers, vol. 12, no. 11, 3100
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter?

    Gamble, D., Buono, R., Mamas, M. A., Leslie, S., Bettencourt-Silva, J. H., Clark, A. B., Bowles, K. M., Metcalf, A. K., Potter, J. F., Myint, P. K.
    European Journal of Preventive Cardiology, vol. 27, no. 7, pp. 729-737
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Hypertensive disorders of pregnancy and subsequent cardiovascular disease: current national and international guidelines and the need for future research

    Gamble, D., Brikinns, B., Myint, P. K., Bhattacharya, S.
    Frontiers in cardiovascular medicine, vol. 6, 55
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Baseline anticholinergic burden from medications predicts incident fatal and non-fatal stroke in the EPIC-Norfolk general population

    Gamble, D., Clark, A. B., Luben, R. N., Wareham, N. J., Khaw, K., Myint, P. K.
    International Journal of Epidemiology, vol. 47, no. 2, pp. 625-633
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Screening for valve disease in patients with hyperprolactinaemia disorders prescribed cabergoline: a service evaluation and literature review

    Gamble, D., Fairley, R., Harvey, R., Farman, C., Cantley, N., Leslie, S. J.
    Therapeutic Advances in Drug Safety, vol. 8, no. 7, pp. 215-229
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Impact of implementation of the National Early Warning Score on patients and staff

    Farenden, S., Gamble, D., Welch, J.
    British Journal of Hospital Medicine, vol. 78, no. 3, pp. 132-136
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Takotsubo cardiomyopathy with severe bradyarrhythmia following epidural insertion

    Gamble, D. T., Shuttleworth, K. J., Scally, C., Leslie, S. J.
    BMJ Case Reports, vol. 2016, 216946
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
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