51cg

People

Dr Dawn Thompson

Dr Dawn Thompson
Dr Dawn Thompson
Dr Dawn Thompson

BSc, PhD

Lecturer

51cg
Email Address
dthompson@abdn.ac.uk
Office Address

office 6.15/lab 2.48

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences,

Foresterhill, Aberdeen

ext: office:7513

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I received my B.Sc Hons in Pharmacology from the 51cg before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity.  I returned to the 51cg and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.     

Research

Research Overview

My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.  

Research Areas

Biomedical Sciences

View Research Area

Research Specialisms

  • Pharmacology
  • Neuroscience
  • Cell Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Publications

Page 1 of 1 Results 1 to 35 of 35

  • Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

    Atkinson, S. J., Negoita, F., Ioi, Y., Ritchie, W. V., Thompson, K., Gardner, M., Ashdown, P. T., Hellberg, K., Takahara, T., Sakamoto, K., Thompson, D., Hislop, J. N., Hatakeyama, R.
    The Biochemical journal, vol. 483, no. 10, pp. 1817-1834
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Investigation into ligand selectivity and bias at the formyl peptide receptor family

    Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.
    Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents

    He, M., Thomson, C., Thompson, D., Kuodis, V., Smith, T., Dall'Angelo, S., O'hagan, D.
    ChemBioChem, vol. 26, no. 22, e202500384
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Identification of a regulatory sequence within the third intracellular loop that governs β-arrestin binding to the muscarinic M5 receptor

    Steinmüller, S., Thompson, K., Alenfelder, J., Drube, J., Hoffmann, C., Kostenis, E., Thompson, D., Hislop, J.
    Cellular Signalling, vol. 135, 112004
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., McIlroy, G. D., Rochford, J., Mody, N.
    Experimental Physiology, vol. 110, no. 8, pp. 1071-1086
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

    Leeson-Payne, A., Iyinikkel, J., Malcolm, C., Lam, B. Y. H., Sommer, N., Dowsett, G. K. C., Blanco Martinez de Morentin, P., Thompson, D., MacKenzie, A., Chianese, R., Kentistou, K. A., Gardner, E. J., Perry, J. R., Grassmann, F., Speakman, J., Rochford, J., Yeo, G. S. H., Murray, F., Heisler, L.
    Cell Metabolism, vol. 36, no. 5, pp. 1076-1087
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A refined method of adult tissue resident stem cell derived primary human hepatic organoid cultures

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • FGF21 sensitivity in hepatocellular carcinoma could be impaired through reduction in FGFR1 and KLB expression

    Clegg, F., McLean, M. H., Thompson, D., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., Mcilroy, G. D., Rochford, J. J., Mody, N.
    Working Papers: Preprint Papers
    • [ONLINE] DOI:

  • P125: Development and Evaluation of a Novel Antibody to Human FGF21

    Clegg, F., Addawiyah Imawana, R., Alnabulsi, A., McLean, M. H., Thompson, D., Delibegovic, M., Murray, G.
    Journal of Pathology, vol. 261, no. S1, pp. S63
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

    Helk, O., Dekeryte, R., Thompson, D., Kamli-Salino, S., Philip, S., Wilson, H. M., Mody, N., Delibegovic, M.
    Journal of translational medicine, vol. 21, 715
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Generating a novel 3D primary human hepatic organoid model for study of metabolic diseases

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice

    Thompson, D., Mahmood, S., Morrice, N., Kamli-Salino, S., Dekeryte, R., Hoffmann, P., Doherty, M. K., Whitfield, P. D., Delibegović, M., Mody, N.
    Scientific Reports, vol. 13, 3937
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Using Game of Thrones to teach physiology during lockdown and beyond.

    Scott, D. A., Hislop, J., Murray, F., Thompson, D.
    Europhysiology 2022, pp. 263-264
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Using Game of Thrones to teach neuroscience and neuropharmacology during lockdown

    Scott, D. A., Hislop, J., Murray, F., Thompson, D.
    51cg Annual Academic Development Symposium 2021
    Contributions to Conferences: Posters

  • Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion

    Verschoor, P. J., Greig, F. H., Rochford, J., Levate', G., Delibegovic, M., Thompson, D., Leeson-Payne, A., Dekeryte, R., Banks, R., Ramos, J. W., Nixon, G.
    Scientific Reports, vol. 11, 6949
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Design, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents

    Patruno, I., Thompson, D., Dall'angelo, S., Windhorst, A. D., Vugts, D. J., Poot, A. J., Mody, N., Zanda, M.
    ChemMedChem, vol. 15, no. 16, pp. 1579-1590
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Endocytic Sorting and Downregulation of the M2 Acetylcholine Receptor is Regulated by Ubiquitin and the ESCRT Complex

    Zenko, D., Thompson, D., Hislop, J. N.
    Neuropharmacology, vol. 162, 107828
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Response to comment by Moxon et al

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M., Delibegovic, M.
    Clinical Science, vol. 132, no. 1, pp. 39-41
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M., Delibegovic, M.
    Clinical Science, vol. 131, no. 20, pp. 2489-2501
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. M., Delibegovic, M.
    Molecular Metabolism, vol. 6, no. 8, pp. 845-853
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Novel G protein-coupled receptors in Pancreatic Beta cells

    Saunders, F., Iyinikkel, J., Lima, M., Thompson, D., Delibegovic, M., Docherty, K., Murray, F.
    Experimental Biology, 1052.1
    Contributions to Journals: Abstracts
    • [ONLINE]

  • Identification of a novel recycling sequence in the C-tail of FPR2/ALX: association with cell protection from apoptosis

    Thompson, D., McArthur, S., Hislop, J. N., Flower, R. J., Perretti, M.
    The Journal of Biological Chemistry, vol. 289, pp. 36166-36178
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

    Cooray, S. N., Gobbetti, T., Montero-Melendez, T., McArthur, S., Thompson, D., Clark, A. J. L., Flower, R. J., Perretti, M.
    PNAS, vol. 110, no. 45, pp. 18232-18237
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Increased axonal bouton dynamics in the aging mouse cortex

    Grillo, F. W., Song, S., Teles-Grilo Ruivo, L. M., Huang, L., Gao, G., Knott, G. W., Maco, B., Ferretti, V., Thompson, D., Little, G. E., De Paola, V.
    PNAS, vol. 110, no. 16, pp. E1514-E1523
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Trafficking properties of the D5 dopamine receptor

    Thompson, D., Whistler, J. L.
    Traffic, vol. 12, no. 5, pp. 644-56
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions

    Tschammer, N., Elsner, J., Goetz, A., Ehrlich, K., Schuster, S., Ruberg, M., Kühhorn, J., Thompson, D., Whistler, J., Hübner, H., Gmeiner, P.
    Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2477-91
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1

    Thompson, D., Whistler, J. L.
    The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1598-608
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine

    Thompson, D., Martini, L., Whistler, J. L.
    PloS ONE, vol. 5, no. 6, pp. e11038
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1

    Martini, L., Thompson, D., Kharazia, V., Whistler, J. L.
    Neuropsychopharmacology, vol. 35, no. 6, pp. 1363-73
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28

    Tschische, P., Moser, E., Thompson, D., Vischer, H. F., Parzmair, G. P., Pommer, V., Platzer, W., Schwarzbraun, T., Schaider, H., Smit, M. J., Martini, L., Whistler, J. L., Waldhoer, M.
    Traffic, vol. 11, no. 5, pp. 660-74
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors

    Thompson, D., Pusch, M., Whistler, J. L.
    The Journal of Biological Chemistry, vol. 282, no. 40, pp. 29178-85
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies

    Yeung, S. Y. M., Thompson, D., Wang, Z., Fedida, D., Robertson, B.
    Journal of Neuroscience, vol. 25, no. 38, pp. 8735-45
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

    Delon, C., Manifava, M., Wood, E., Thompson, D., Krugmann, S., Pyne, S., Ktistakis, N. T.
    The Journal of Biological Chemistry, vol. 279, no. 43, pp. 44763-74
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

    Waters, C., Sambi, B., Kong, K., Thompson, D., Pitson, S. M., Pyne, S., Pyne, N. J.
    The Journal of Biological Chemistry, vol. 278, no. 8, pp. 6282-90
    Contributions to Journals: Articles
    • [ONLINE] DOI:

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