51cg

People

Dr Dawn Thompson

Dr Dawn Thompson
Dr Dawn Thompson
Dr Dawn Thompson

BSc, PhD

Lecturer

51cg
Email Address
dthompson@abdn.ac.uk
Office Address

office 6.15/lab 2.48

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences,

Foresterhill, Aberdeen

ext: office:7513

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I received my B.Sc Hons in Pharmacology from the 51cg before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity.  I returned to the 51cg and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.     

Research

Research Overview

My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.  

Research Areas

Biomedical Sciences

View Research Area

Research Specialisms

  • Pharmacology
  • Neuroscience
  • Cell Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Publications

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  • Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

    Helk, O., Dekeryte, R., Thompson, D., Kamli-Salino, S., Philip, S., Wilson, H. M., Mody, N., Delibegovic, M.
    Journal of translational medicine, vol. 21, 715
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Generating a novel 3D primary human hepatic organoid model for study of metabolic diseases

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice

    Thompson, D., Mahmood, S., Morrice, N., Kamli-Salino, S., Dekeryte, R., Hoffmann, P., Doherty, M. K., Whitfield, P. D., Delibegović, M., Mody, N.
    Scientific Reports, vol. 13, 3937
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Using Game of Thrones to teach physiology during lockdown and beyond.

    Scott, D. A., Hislop, J., Murray, F., Thompson, D.
    Europhysiology 2022, pp. 263-264
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Using Game of Thrones to teach neuroscience and neuropharmacology during lockdown

    Scott, D. A., Hislop, J., Murray, F., Thompson, D.
    51cg Annual Academic Development Symposium 2021
    Contributions to Conferences: Posters

  • Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion

    Verschoor, P. J., Greig, F. H., Rochford, J., Levate', G., Delibegovic, M., Thompson, D., Leeson-Payne, A., Dekeryte, R., Banks, R., Ramos, J. W., Nixon, G.
    Scientific Reports, vol. 11, 6949
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Design, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents

    Patruno, I., Thompson, D., Dall'angelo, S., Windhorst, A. D., Vugts, D. J., Poot, A. J., Mody, N., Zanda, M.
    ChemMedChem, vol. 15, no. 16, pp. 1579-1590
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Endocytic Sorting and Downregulation of the M2 Acetylcholine Receptor is Regulated by Ubiquitin and the ESCRT Complex

    Zenko, D., Thompson, D., Hislop, J. N.
    Neuropharmacology, vol. 162, 107828
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Response to comment by Moxon et al

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M., Delibegovic, M.
    Clinical Science, vol. 132, no. 1, pp. 39-41
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M., Delibegovic, M.
    Clinical Science, vol. 131, no. 20, pp. 2489-2501
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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