BSc (Hons) Genetics, PhD
Research Fellow
- 51cg
-
- Email Address
- g.mcilroy@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition




Biography
09/2021 - Present: Diabetes UK RD Lawrence Fellow, 51cg
03/2019 - 06/2021: Diabetes UK Postdoctoral Research Fellow, 51cg
03/2018 - 03/2019: Wellcome Trust ISSF Research Fellow, 51cg
12/2014 - 03/2018: MRC Postdoctoral Research Fellow, 51cg
10/2010 - 12/2014: PhD, 51cg
09/2005 - 09/2009: BSc (Hons) Genetics, University of Glasgow
Qualifications
- PhD Integrative Physiology2014 - 51cg
- BSc Genetics (Hons)2009 - University of Glasgow
Memberships and Affiliations
- Internal Memberships
-
BSU Team Committee Member (2019 - Present, Academic representative)
Rowett Institute Tissue Culture Facility Team (2024 - Present, Academic lead)
- External Memberships
-
(2015 - Present, Professional Member)
Latest Publications
Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice
Experimental Physiology, vol. 110, no. 8, pp. 1071-1086Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Osteoarthritis and Cartilage, vol. 32, no. 12, pp. 1552-1565Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Gene Therapy, vol. 31, pp. 445–454Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28–29 September 2023
Contributions to Journals: Conference Articles- [ONLINE] DOI:
- [ONLINE]
GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy
Frontiers in Endocrinology, vol. 15, 1379228Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Prizes and Awards
Diabetes UK Innovators in Diabetes 2024 - Presentation Winner
- Research
-
Research Overview
I am interested in the development and function of adipose tissue (body fat). In conditions such as obesity, adipose tissue becomes dysfunctional and no longer safely stores dietary fats. This can lead to severe metabolic complications such as diabetes, fatty liver, cardiovascular disease and some cancers.
Some people are unable to make adipose tissue. These rare disorders are known as lipodystrophies. Here, the lack of body fat and inability to safely store dietary fats causes similar metabolic complications to those observed in obesity. For more information on lipodystrophies, visit the , the UK’s only charity dedicated to supporting people affected by Lipodystrophy, which is a rare and life threatening disease affecting approximately 1 in 1 million people across the world.
My current research utilises mouse models of lipodystrophy to investigate this disorder. My aim is to discover novel therapeutic treatment strategies for patients suffering from lipodystrophy. However, rare disorders such as lipodystrophy can also be used to identify new treatments for more common forms of type 2 diabetes often observed in conditions of obesity.

Research Areas
Research Specialisms
- Biological Sciences
- Molecular Biology
- Animal Physiology
- Endocrinology
- Diabetes
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Knowledge Exchange
Lipodystrophy UK Patient Day (27/03/2026)
Invited speaker


Bucksburn Academy S3 Life Science Class Visit (10/12/2025)
An introduction to the polymerase chain reaction: PCR


(09/09/25)
Co-organised and hosted at the Rowett Institute as part of the UKCO meeting held in Aberdeen
Rowett Institute “Doors Open Day” (06/09/2025)
Tours of the building to members of the public
Kemnay Academy Advanced Higher Biology/Science Baccalaureate Visit (01/02/2023)
PCR practical and Scientific Poster workshop


Invited speaker (21/05/2019)
Aberdeen, Scotland
Cell Block Science Interactive stall (24/10/2018)
HMP Grampian
Interactive stall (28/09/2018)
Aberdeen Science Centre
Supervision
Ms Mansi Tiwari joined the Mcilroy lab in October 2022 to commence her PhD. Here she will combine gene therapy and cutting edge multiomic next generation sequencing analysis at single cell resolution to identify novel treatments for type 2 diabetes.

Funding and Grants
Daisy Duncan Legacy Award for Cardiac Research 2025 (£10,000, PI)
New Drivers of Hypertrophic Cardiomyopathy
(£495,283, PI)
Exploiting gene therapy to discover treatments for type 2 diabetes
Wellcome Trust ISSF Seed Corn Fund 2020 (£17,469, Co-I)
Developing viral therapeutics for the treatment of severe diabetes and metabolic disease in lipodystrophy.
10X Genomics/illumina core facility grant @ CGEBM 2019 (~£10,000, PI)
Adipose tissue chromatin profiling in generalised lipodystrophy at single cell resolution
(€50,000, PI)
Identifying Novel Therapies to Prevent Diabetes in Congenital Lipodystrophy.
Wellcome Trust ISSF Fellowship Support Award 2018 (£60,000, PI)
Does Bscl2 disruption in the liver contribute to metabolic dysfunction in lipodystrophy?
- Teaching
-
Teaching Responsibilities
MSc Human Nutrition - Molecular Nutrition (RN5502)
Molecular Biology of Lipodystrophy
MSc Diabetes and Metabolism (BM5502)
Sleeve gastrectomy data analysis tutorial
Research Skills For Medical Sciences (SM2501)
Tutor for disease tutorial
- Publications
-
Page 1 of 3 Results 1 to 10 of 25
Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice
Experimental Physiology, vol. 110, no. 8, pp. 1071-1086Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Osteoarthritis and Cartilage, vol. 32, no. 12, pp. 1552-1565Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Gene Therapy, vol. 31, pp. 445–454Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28–29 September 2023
Contributions to Journals: Conference Articles- [ONLINE] DOI:
- [ONLINE]
GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy
Frontiers in Endocrinology, vol. 15, 1379228Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice
Working Papers: Preprint Papers- [ONLINE] DOI:
From Scarcity to Solutions: Therapeutic Strategies to Restore Adipose Tissue Functionality in Rare Disorders of Lipodystrophy
Diabetic Medicine, vol. 40, no. 12, e15214Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy
Molecular Therapy - Methods & Clinical Development, vol. 27, pp. 206-216Contributions to Journals: Articles- [ONLINE]
- [ONLINE] DOI:
- [OPEN ACCESS]
High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide
Nutritional Neuroscience, vol. 25, no. 4, pp. 719-736Contributions to Journals: Articles- [ONLINE] DOI:
- [ONLINE]
Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy
Journal of Clinical Medicine, vol. 10, no. 3, 441Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]