51cg

Dr George McIlroy

Dr George McIlroy
Dr George McIlroy
Dr George McIlroy

BSc (Hons) Genetics, PhD

Research Fellow

51cg
Email Address
g.mcilroy@abdn.ac.uk
Office Address
4.048 The Rowett Institute
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition




Biography

09/2021 - Present: Diabetes UK RD Lawrence Fellow, 51cg 

03/2019 - 06/2021: Diabetes UK Postdoctoral Research Fellow, 51cg

03/2018 - 03/2019: Wellcome Trust ISSF Research Fellow, 51cg

12/2014 - 03/2018: MRC Postdoctoral Research Fellow, 51cg

10/2010 - 12/2014: PhD, 51cg

09/2005 - 09/2009: BSc (Hons) Genetics, University of Glasgow

Qualifications

  • PhD Integrative Physiology 
    2014 - 51cg 
  • BSc Genetics (Hons) 
    2009 - University of Glasgow 

Memberships and Affiliations

Internal Memberships

BSU Team Committee Member (2019 - Present, Academic representative)

Rowett Institute Tissue Culture Facility Team (2024 - Present, Academic lead)

External Memberships

 (2015 - Present, Professional Member)

Latest Publications

  • Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., McIlroy, G. D., Rochford, J., Mody, N.
    Experimental Physiology, vol. 110, no. 8, pp. 1071-1086
    Contributions to Journals: Articles
  • Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee

    McClure, J., McIlroy, G. D., Symons, R., Clark, S., Cunningham, I., Han, W., Kania, K., Colella, F., Rochford, J., De Bari, C., Roelofs, A.
    Osteoarthritis and Cartilage, vol. 32, no. 12, pp. 1552-1565
    Contributions to Journals: Articles
  • Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy

    Tiwari, M., Roumane, A., Sommer, N., Han, W., Delibegovic, M., Rochford, J., McIlroy, G. D.
    Gene Therapy, vol. 31, pp. 445–454
    Contributions to Journals: Articles
  • Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28–29 September 2023

    Ceccarini, G., Akinci, B., Araujo-Vilar, D., Beghini, M., Brown, R. J., Carrion Tudela, J., Corradin, V., Donadille, B., Jerez Ruiz, J., Jeru, I., Lattanzi, G., Maffei, M., McIlroy, G. D., Nobécourt, E., Perez de Tudela, N., Rochford, J. J., Sanders, R., von Schnurbein, J., Tews, D., Vantyghem, M. C., Vatier, C., Vigouroux, C., Santini, F.
    Contributions to Journals: Conference Articles
  • GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy

    Roumane, A., Mcilroy, G. D., Sommer, N., Han, W., Heisler, L. K., Rochford, J. J.
    Frontiers in Endocrinology, vol. 15, 1379228
    Contributions to Journals: Articles

View My Publications

Prizes and Awards

Diabetes UK Innovators in Diabetes 2024 - Presentation Winner

 

Research

Research Overview

I am interested in the development and function of adipose tissue (body fat). In conditions such as obesity, adipose tissue becomes dysfunctional and no longer safely stores dietary fats. This can lead to severe metabolic complications such as diabetes, fatty liver, cardiovascular disease and some cancers.

Some people are unable to make adipose tissue. These rare disorders are known as lipodystrophies. Here, the lack of body fat and inability to safely store dietary fats causes similar metabolic complications to those observed in obesity. For more information on lipodystrophies, visit the , the UK’s only charity dedicated to supporting people affected by Lipodystrophy, which is a rare and life threatening disease affecting approximately 1 in 1 million people across the world. 

My current research utilises mouse models of lipodystrophy to investigate this disorder. My aim is to discover novel therapeutic treatment strategies for patients suffering from lipodystrophy. However, rare disorders such as lipodystrophy can also be used to identify new treatments for more common forms of type 2 diabetes often observed in conditions of obesity.

IMG_0268-Enhanced-NR.jpg    

Research Areas

Biomedical Sciences

Nutrition and Health

Research Specialisms

  • Biological Sciences
  • Molecular Biology
  • Animal Physiology
  • Endocrinology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Knowledge Exchange

Lipodystrophy UK Patient Day (27/03/2026)

Invited speaker

LDUK26.jpgLDUK26_2.jpg

Bucksburn Academy S3 Life Science Class Visit (10/12/2025)

An introduction to the polymerase chain reaction: PCR

IMG_9384.JPEGIMG_9397.JPEG

 (09/09/25)

Co-organised and hosted at the Rowett Institute as part of the UKCO meeting held in Aberdeen

Rowett Institute “Doors Open Day” (06/09/2025)

Tours of the building to members of the public 

Kemnay Academy Advanced Higher Biology/Science Baccalaureate Visit (01/02/2023) 

PCR practical and Scientific Poster workshop

ScientificPoster.jpg         PCRPractical.jpg

 Invited speaker (21/05/2019)

Aberdeen, Scotland

Cell Block Science Interactive stall (24/10/2018)

HMP Grampian

 Interactive stall (28/09/2018)

Aberdeen Science Centre

Supervision

Ms Mansi Tiwari joined the Mcilroy lab in October 2022 to commence her PhD. Here she will combine gene therapy and cutting edge multiomic next generation sequencing analysis at single cell resolution to identify novel treatments for type 2 diabetes.

MansiTiwari.jpg

Funding and Grants

Daisy Duncan Legacy Award for Cardiac Research 2025 (£10,000, PI)

New Drivers of Hypertrophic Cardiomyopathy

(£495,283, PI)

Exploiting gene therapy to discover treatments for type 2 diabetes

Wellcome Trust ISSF Seed Corn Fund 2020 (£17,469, Co-I)

Developing viral therapeutics for the treatment of severe diabetes and metabolic disease in lipodystrophy.

10X Genomics/illumina core facility grant @ CGEBM 2019 (~£10,000, PI)

Adipose tissue chromatin profiling in generalised lipodystrophy at single cell resolution

 (€50,000, PI)

Identifying Novel Therapies to Prevent Diabetes in Congenital Lipodystrophy.

Wellcome Trust ISSF Fellowship Support Award 2018 (£60,000, PI)

Does Bscl2 disruption in the liver contribute to metabolic dysfunction in lipodystrophy?

Teaching

Teaching Responsibilities

MSc Human Nutrition - Molecular Nutrition (RN5502)

Molecular Biology of Lipodystrophy

 

MSc Diabetes and Metabolism (BM5502)

Sleeve gastrectomy data analysis tutorial

 

Research Skills For Medical Sciences (SM2501)

Tutor for disease tutorial

Publications

Page 1 of 3 Results 1 to 10 of 25

  • Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., McIlroy, G. D., Rochford, J., Mody, N.
    Experimental Physiology, vol. 110, no. 8, pp. 1071-1086
    Contributions to Journals: Articles
  • Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee

    McClure, J., McIlroy, G. D., Symons, R., Clark, S., Cunningham, I., Han, W., Kania, K., Colella, F., Rochford, J., De Bari, C., Roelofs, A.
    Osteoarthritis and Cartilage, vol. 32, no. 12, pp. 1552-1565
    Contributions to Journals: Articles
  • Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy

    Tiwari, M., Roumane, A., Sommer, N., Han, W., Delibegovic, M., Rochford, J., McIlroy, G. D.
    Gene Therapy, vol. 31, pp. 445–454
    Contributions to Journals: Articles
  • Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28–29 September 2023

    Ceccarini, G., Akinci, B., Araujo-Vilar, D., Beghini, M., Brown, R. J., Carrion Tudela, J., Corradin, V., Donadille, B., Jerez Ruiz, J., Jeru, I., Lattanzi, G., Maffei, M., McIlroy, G. D., Nobécourt, E., Perez de Tudela, N., Rochford, J. J., Sanders, R., von Schnurbein, J., Tews, D., Vantyghem, M. C., Vatier, C., Vigouroux, C., Santini, F.
    Contributions to Journals: Conference Articles
  • GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy

    Roumane, A., Mcilroy, G. D., Sommer, N., Han, W., Heisler, L. K., Rochford, J. J.
    Frontiers in Endocrinology, vol. 15, 1379228
    Contributions to Journals: Articles
  • Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., Mcilroy, G. D., Rochford, J. J., Mody, N.
    Working Papers: Preprint Papers
  • From Scarcity to Solutions: Therapeutic Strategies to Restore Adipose Tissue Functionality in Rare Disorders of Lipodystrophy

    Tiwari, M., Mcilroy, G. D.
    Diabetic Medicine, vol. 40, no. 12, e15214
    Contributions to Journals: Articles
  • Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

    Sommer, N., Roumane, A., Han, W., Delibegović, M., Rochford, J. J., Mcilroy, G. D.
    Molecular Therapy - Methods & Clinical Development, vol. 27, pp. 206-216
    Contributions to Journals: Articles
  • High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide

    Plucińska, K., Mody, N., Dekeryte, R., Shearer, K., McIlroy, G., Delibegovic, M., Platt, B.
    Nutritional Neuroscience, vol. 25, no. 4, pp. 719-736
    Contributions to Journals: Articles
  • Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy

    Roumane, A., Mcilroy, G. D., Balci, A., Han, W., Delibegović, M., Baldassarre, M., Newsholme, P., Rochford, J. J.
    Journal of Clinical Medicine, vol. 10, no. 3, 441
    Contributions to Journals: Articles
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