51cg

People

Dr Maria Cascio

Dr Maria Cascio
Dr Maria Cascio
Dr Maria Cascio

Ph.D, AFHEA

Senior Equality, Diversity and Inclusion Partner

51cg
Email Address
m.cascio@abdn.ac.uk
Office Address
102-103 University Office
Old Aberdeen Campus
Regent Walk
AB24 3FX

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School/Department
People & Student Services

Biography

I graduated in July 2002 in Chemistry and Pharmaceutical Technologies (Master degree-UK equivalent) from the University of Palermo (Italy), obtaining the highest mark possible under the system (110/110 cum laude).

From September 2000 to June 2007 I was based in Naples where I joined the “Endocannabinoid Research Group”, at the National Council of Research. There, I started my research aimed at understanding the involvement of the “Endocannabinoid System” in both pathological and physiological conditions.

In 2006 I obtained my PhD in Pharmaceutical Chemistry (University of Fisciano, Salerno, Italy).

In 2007, I moved to the 51cg and as Research Fellow (supported by GW Pharmaceuticals) I have been involved, in collaboration with Professor Roger Pertwee, in the pharmacological in vitro characterization of new Cannabis-derived cannabinoids. In 2014 I was promoted to Research Fellow, Grade 7 (Lecturer grade).

I am co-author of more than 80 peer-reviewed papers and 6 book chapters. You can see my publications here:

Currently, I am University Senior Equality, Diversity and Inclusion Partner supporting work aimed at addressing the barriers faced by underrepresented groups.  If you wish to get in touch, please email me! m.cascio@abdn.ac.uk

Qualifications

  • PhD Pharmaceutical Chemistry 
    2006 - University of Fisciano, Salerno, Italy 

Memberships and Affiliations

Internal Memberships

Membership of Professional Bodies/Committees/Worki

Clerk and active member of the University Race Equality Strategy Group

Member of the University Equality, Diversity and Inclusion Committee

Member of School Equality, Diversity and Inclusion Committees (STEMM)

Member of the University Annual Review Steering Group

Social Bias Observer at Promotions Committees

 

 

 

 

 

 

 

External Memberships

Professional activities

  • Radiation Protection Supervisor, Level 6th, Institute of Medical Sciences, 51cg, (2012-2014).
  • Guest Associate Editor, Frontiers in Neuropharmacology, Research topic:”Additive drugs targeting GPCRs: new cross-talk mechanisms" (2013-2014).  
  • Associate Fellow of the Higher Education Academy, since 2012
  • Paper co-evaluator at F1000 faculty (www.F1000biology.com)
  • Peer reviewer of international scientific journals
  • Book reviewer: “Cannabinoids in Nature and Medicine”, Didier M. Lambert Editor

Prizes and Awards

Principal's Excellence Award on Equality, Diversity and Sustainability, April 2026.

Research

Research Overview

Main research interests are:

. Medicinal chemistry

. Pharmacology and therapeutic potential of plant cannabinoids

· Pharmacology of allosteric sites on cannabinoid receptors

·  Novel cannabinoid CB1 and CB2 receptor ligands

·  New pharmacological targets for cannabinoids

·  Roles of the endocannabinoid system in health and disease

. Anti-proliferative effects of the omega 3 fatty acids/ethanolamides in prostate cancer

Technical Experience

Biochemistry assays: Western Blotting, PCR, Plasmid Transfection, Lipid extraction from tissues and cells.

Immunofluorimetric assays: p-ERK 1/2 AlphaScreen®, SureFire® (Envision, Perkin Elmer), E.L.I.S.A., cyclic AMP, β-arrestin.

Pharmacological assay: [35S]GTPγS binding, [3H]Displacement binding, Impedance-based system (RT-CES®) for dynamic monitoring of GPCRs activation in living cells.

Chromatography (Silica gel and HPLC).

Cells culturing

Simple synthesis of chemical tools

 

Current Research

Maria Grazia Cascio's current research is directed at elucidating the pharmacological actions of plant cannabinoids such as cannabidiol (CBD), delta-9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG). In addition, she is currently involved in projects aimed at identifying new potent and selective ligands for the cannabinoid CB1 and CB2 receptors. For this she is collaborating with chemists based in Italy.

My research also focuses on the study of the anti-proliferative effects of two fish oil omega 3 fatty acids (DHA and EPA) and their ethanolamides (DHEA and EPEA) in two prostate cancer cell lines, PC3 and LNCaP.

Collaborations

Internal collaborators

Dr Iain Brown (Project: Prostate cancer)

Professor Matteo Zanda (Project: New CB1 ligands for PET)

Dr Mirela Delibegovic (Project: The study of the involvement of the endocannabinoid system in diabetic nephropathy).

External collaborators

Dr Ben Whalley, University of Reading (Project: The anticonvulsant properties of some plant-derived cannabinoids);

Professor Angelo Izzo, University “Federico II” of Naples (Project: The ability of some plant-derived cannabinoids to ameliorate murine colitis;

Professor Daniela Parolaro, University of Milan (Project: The ability of some plant-derived cannabinoids to ameliorate schizophrenia);

Dr Barbara Costa, University of Busto Arstizio (Project: Investigation of the analgesic properties of the plant-derived cannabigerol),

Dr Ganesh Takhur, (Department of Pharmaceutical Sciences, Northeastern University, Boston) (Project: Investigation of the pharmacological profile of new synthetic CB1 cannabinoid receptor Positive Allosteric Modulators);

Professor Federico Corelli and Dr Antonella Brizzi, (University of Siena),

Professor Giovanni Appendino (University of Novara);

Professor Romano Silvestri and Professor Giorgio Ortar (University of Rome).

Funding and Grants

Delibegovic M, Cascio MG and Pertwee RG. Diabetes. Eighteen months (2014-2016). 

Takhur G, Cascio MG, Pertwee RG et al.,. NIDA. Five years (2014 to 2019).

Pertwee RG and Cascio MG. Honours Student Project, 10 weeks (January 2014 - March 2014), 51cg, 

Cascio MG. Summer student from Brazil, 3 months (June 2013 - August, 2013), 51cg, 

Cascio MG, Marini P, Brown I, Pertwee R.G. NHS Grampian Endowment Research Fund, Scotland, UK. One year (April 2013- March 2014). .

Brown I, Cascio MG, Sneddon AA, Wahle KWJ, Pertwee RG, Heys SD. Fraserburgh Moonlight Prowl and 51cg. PhD studentship in Nutrition and Cancer. Three years (2010 to 2013). Student stipend, home/EU fees and consumables.

Cascio MG and Pertwee RG. Honours Student Project, 10 weeks (January 2012 - March 2012), 51cg, 

Brown I, Cascio MG, Heys SD, Pertwee RG. & Ross RA. Tenovus Scotland. One year (April 2010-March 2011). 

Brown I, Cascio MG. & Pertwee RG.  NHS GRAMPIAN ENDOWMENTS. One year (April 2010-March 2011). 

 

Teaching

Teaching Responsibilities

Supervisor of both undergraduate and PhD students

Student tutor in Life Sciences subjects

Publications

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  • Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Marini, P., Cascio, M. G., Pertwee, R. G.
    Endocannabinoid Signaling.. Maccarrone, M. (ed.). HUMANA PRESS INC, pp. 171-179, 9 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Cascio, M. G., Marini, P., Pertwee, R. G.
    Endocannabinoid Signaling.: Methods in Molecular Biology. Maccarrone, M. (ed.). HUMANA PRESS INC, pp. 111-118, 8 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2

    Raphael-Mizrahi, B., Attar-Namdar, M., Chourasia, M., Cascio, M. G., Shurki, A., Tam, J., Neuman, M., Rimmerman, N., Vogel, Z., Shteyer, A., Pertwee, R. G., Zimmer, A., Kogan, N. M., Bab, I., Gabet, Y.
    eLife, e65834
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity

    Brizzi, A., Aiello, F., Boccella, S., Cascio, M. G., De Petrocellis, L., Frosini, M., Gado, F., Ligresti, A., Luongo, L., Marini, P., Mugnaini, C., Pessina, F., Corelli, F., Maione, S., Manera, C., Pertwee, R. G., Di Marzo, V.
    Bioorganic and Medicinal Chemistry, vol. 28, no. 11, 115513
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

    Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W., Rotondo, D., Heys, S. D.
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 156, pp. 102024
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

    Laprairie, R. B., Kulkarni, P. M., Deschamps, J. R., Kelly, M. E., Janero, D. R., Cascio, M. G., Stevenson, L. A., Pertwee, R. G., Kenakin, T. P., Denovan-Wright, E. M., Thakur, G. A.
    ACS Chemical Neuroscience, vol. 8, no. 6, pp. 1188-1203
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • The pharmacology and therapeutic potential of plant cannabinoids

    Cascio, M. G., Pertwee, R. G., Marini, P.
    Cannabis sativa L. - Botany and Biotechnology. Chandra, S., Lata, H., ElSohly, M. (eds.). Springer, Biomedicine & Life Sciences, pp. 207-225, 19 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Exploring the Benzimidazole Ring as a Substitution for Indole in Cannabinoid Allosteric Modulators

    Hernandez-Folgado, L., Stevenson, L. A., Morales, P., Gómez-Cañas, M., Pazos, M. R., Cascio, M. G., Jagerovic, N., Elguero, J., Pertwee, R., Goya, P.
    Cannabis and Cannabinoid Research, vol. 1, no. 1, pp. 196-201
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Pure Δ9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages

    Romano, B., Pagano, E., Orlando, P., Capasso, R., Cascio, M. G., Pertwee, R., Marzo, V. D., Izzo, A. A., Borrelli, F.
    Pharmacological Research, vol. 113, no. A, pp. 199-208
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Cascio, M. G., Marini, P., Pertwee, R. G.
    Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). Springer Science+Business Media, pp. 57-63, 7 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

    Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G., Thakur, G. A.
    Journal of Medicinal Chemistry, vol. 59, no. 1, pp. 44-60
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Marini, P., Cascio, M. G., Pertwee, R. G.
    Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). Springer Science+Business Media, pp. 85-93, 9 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

    Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R., Bab, I.
    PNAS, vol. 112, no. 28, pp. 8774-8779
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A1-adenosine acute withdrawal response and cholecystokinin-8 induced contractures are regulated by Ca2+- and ATP-activated K+ channels

    Cascio, M. G., Valeri, D., Tucker, S. J., Marini, P.
    Pharmacological Research, vol. 95-96, pp. 82-91
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D., Pertwee, R. G.
    British Journal of Pharmacology, vol. 172, no. 5, pp. 1305-1318
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

    Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A., Zanda, M.
    Synthesis, vol. 47, no. 6, pp. 817-826
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Biosynthesis and fate of endocannabinoids

    Cascio, M. G., Marini, P.
    Endocanabinoids: Handbook of Experimental Pharmacology. Pertwee, R. G. (ed.). Springer Verlag, pp. 39-58, 10 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

    Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R., Zanda, M.
    Journal of Fluorine Chemistry, vol. 167, pp. 184-191
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G., Di Marzo, V.
    Behavioral and Brain Sciences, vol. 22, no. 17, pp. 4770-4783
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act trough 5HT1A receptors to produce anti-psychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Pertwee, R. G., Parolaro, D.
    Contributions to Conferences: Posters

  • Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

    Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G., Izzo, A. A.
    Phytomedicine, vol. 21, no. 5, pp. 631-639
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • PUFA-derived endocannabinoids: an overview

    Cascio, M. G.
    Proceedings of the Nutrition Society, vol. 72, no. 4, pp. 451-459
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

    Hill, T. D. M., Cascio, M., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J., Hill, A. J.
    British Journal of Pharmacology, vol. 170, no. 3, pp. 679-692
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Effects of Δ9-tetrahydrocannabivarin at serotoninergic 5-HT1A receptors, and of its 11-Hydroxy-metabolite at cannabinoid CB1 and CB2 receptors

    Cascio, M. G., Marini, P., Pertwee, R. G.
    Contributions to Conferences: Posters

  • Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

    Marini, P., Cascio, M. G., King, A., Pertwee, R. G., Ross, R. A.
    British Journal of Pharmacology, vol. 169, no. 4, pp. 887-899
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

    Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M., Pertwee, R., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V., Izzo, A.
    British Journal of Pharmacology, vol. 169, no. 1, pp. 213-229
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

    Bolognini, D., Rock, E., Cluny, N., Cascio, M., Limebeer, C., Duncan, M., Stott, C., Javid, F., Parker, L., Pertwee, R.
    British Journal of Pharmacology, vol. 168, no. 6, pp. 1456-1470
    Contributions to Journals: Articles
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  • Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

    Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D., Wahle, K. W. J.
    Progress in Lipid Research, vol. 52, no. 1, pp. 80-109
    Contributions to Journals: Articles
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  • Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

    Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V., Corelli, F.
    European Journal of Medicinal Chemistry, vol. 58, pp. 30-43
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The NOP receptor involvement in both withdrawal- and CCk-8-induced contracture responses of guinea pig isolated ileum after acute activation of k-opioid receptor

    Marini, P., Romanelli, L., Valeri, D., Cascio, M. G., Tucci, P., Valeri, P., Palmery, M.
    Peptides, vol. 38, no. 2, pp. 418-426
    Contributions to Journals: Articles
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  • Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach

    Mugnaini, C., Nocerino, S., Pedani, V., Pasquini, S., Tafi, A., De Chiaro, M., Bellucci, L., Valoti, M., Guida, F., Luongo, L., Dragoni, S., Ligresti, A., Rosenberg, A., Bolognini, D., Cascio, M. G., Pertwee, R. G., Moaddel, R., Maione, S., Di Marzo, V., Corelli, F.
    ChemMedChem, vol. 7, no. 5, pp. 920-934
    Contributions to Journals: Articles
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  • AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

    Bolognini, D., Cascio, M. G., Parolaro, D., Pertwee, R. G.
    British Journal of Pharmacology, vol. 165, no. 8, pp. 2561-2574
    Contributions to Journals: Articles
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  • Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

    Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G., Parker, L. A.
    British Journal of Pharmacology, vol. 165, no. 8, pp. 2620-2634
    Contributions to Journals: Articles
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  • Novel bioactive metabolites of dipyrone (metamizol)

    Rogosch, T., Sinning, C., Podlewski, A., Watzer, B., Schlosburg, J., Lichtman, A. H., Cascio, M. G., Bisogno, T., Di Marzo, V., Nüsing, R., Imming, P.
    Bioorganic and Medicinal Chemistry, vol. 20, no. 1, pp. 101-107
    Contributions to Journals: Articles
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    • [ONLINE]

  • Biphasic regulation of the acute µ-withdrawal and CCk-8 contracture responses by the ORL-1 system in guinea pig ileum

    Marini, P., Romanelli, L., Valeri, D., Cascio, M. G., Tucci, P., Valeri, P., Palmery, M.
    Pharmacological Research, vol. 65, no. 1, pp. 100-110
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Resorcinol-sn-glycerol derivatives: Novel 2-Arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor

    Brizzi, A., Cascio, M. G., Frosini, M., Ligresti, A., Aiello, F., Biotti, I., Brizzi, V., Pertwee, R. G., Corelli, F., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 54, no. 24, pp. 8278-8288
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

    Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G., Heys, S. D.
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 85, no. 6, pp. 305-310
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

    Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K., Martin, B. R.
    European Journal of Pharmacology, vol. 651, no. 1-3, pp. 96-105
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The function of the endocannabinoid system

    Cascio, M. G., Pertwee, R.
    Marijuana and Madness: Second Edition. Cambridge University Press, pp. 23-34, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

    Brown, I., Cascio, M. G., Wahle, K. W. J., Smoum, R., Mechoulam, R., Ross, R. A., Pertwee, R. G., Heys, S.
    Carcinogenesis, vol. 31, no. 9, pp. 1584-1591
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

    Pasquini, S., Ligresti, A., Mugnaini, C., Semeraro, T., Cicione, L., De Rosa, M., Guida, F., Luongo, L., De Chiaro, M., Cascio, M. G., Bolognini, D., Marini, P., Pertwee, R. G., Maione, S., Di Marzo, V., Corelli, F.
    Journal of Medicinal Chemistry, vol. 53, no. 16, pp. 5915-5928
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

    Bolognini, D., Costa, B., Maione, S., Comelli, F., Marini, P., Di Marzo, V., Parolaro, D., Ross, R. A., Gauson, L. A., Cascio, M. G., Pertwee, R. G.
    British Journal of Pharmacology, vol. 160, no. 3, pp. 677-687
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists

    Cascio, M. G., Bolognini, D., Pertwee, R. G., Palazzo, E., Corelli, F., Pasquini, S., Di Marzo, V., Maione, S.
    Pharmacological Research, vol. 61, no. 4, pp. 349-354
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.

    Cobellis, G., Ricci, G., Cacciola, G., Orlando, P., Petrosino, S., Cascio, M. G., Bisogno, T., De Petrocellis, L., Chioccarelli, T., Altucci, L., Fasano, S., Meccariello, R., Pierantoni, R., Ledent, C., Di Marzo, V.
    BIOLOGY OF REPRODUCTION, vol. 82, no. 2, pp. 451-458
    Contributions to Journals: Articles
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  • Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

    Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A., Pertwee, R. G.
    British Journal of Pharmacology, vol. 159, no. 1, pp. 129-141
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists

    Manera, C., Saccomanni, G., Adinolfi, B., Benetti, V., Ligresti, A., Cascio, M. G., Tuccinardi, T., Lucchesi, V., Martinelli, A., Nieri, P., Masini, E., Di Marzo, V., Ferrarini, P. L.
    Journal of Medicinal Chemistry, vol. 52, no. 12, pp. 3644-3651
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

    Appendino, G., Ligresti, A., Minassi, A., Cascio, M. G., Allara, M., Taglialatela-Scafati, O., Pertwee, R. G., De Petrocellis, L., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 52, no. 9, pp. 3001-3009
    Contributions to Journals: Articles
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  • New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo

    Brizzi, A., Brizzi, V., Cascio, M. G., Corelli, F., Guida, F., Ligresti, A., Maione, S., Martinelli, A., Pasquini, S., Tuccinardi, T., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 52, no. 8, pp. 2506-2514
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • The endocannabinoid system: A general view and latest additions

    De Petrocellis, L., Cascio, M. G., Di Marzo, V.
    Contributions to Journals: Short Survey
    • [ONLINE] DOI:
    • [ONLINE]

  • New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis

    Ligresti, A., Cascio, M. G., Pryce, G., Kulasegram, S., Beletskaya, I., De Petrocellis, L., Saha, B., Mahadevan, A., Visintin, C., Wiley, J. L., Baker, D., Martin, B. R., Razdan, R. K., Di Marzo, V.
    British Journal of Pharmacology, vol. 147, no. 1, pp. 83-91
    Contributions to Journals: Articles
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    • [ONLINE]

  • Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors

    Capasso, R., Borrelli, F., Cascio, M. G., Aviello, G., Huben, K., Zjawiony, J. K., Marini, P., Romano, B., Di Marzo, V., Capasso, F., Izzo, A. A.
    British Journal of Pharmacology, vol. 155, no. 5, pp. 681-689
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  • Novel sterically hindered cannabinoid CB1 receptor ligands

    Urbani, P., Cascio, M. G., Ramunno, A., Bisogno, T., Saturnino, C., Marzo, V. D.
    Bioorganic and Medicinal Chemistry, vol. 16, no. 15, pp. 7510-7515
    Contributions to Journals: Articles
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  • New tetrazole-based selective anandamide uptake inhibitors

    Ortar, G., Schiano Moriello, A., Cascio, M. G., De Petrocellis, L., Ligresti, A., Morera, E., Nalli, M., Di Marzo, V.
    Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 9, pp. 2820-2824
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  • Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides

    Silvestri, R., Cascio, M. G., La Regina, G., Piscitelli, F., Lavecchia, A., Brizzi, A., Pasquini, S., Botta, M., Novellino, E., Di Marzo, V., Corelli, F.
    Journal of Medicinal Chemistry, vol. 51, no. 6, pp. 1560-1576
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  • Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation

    Ortar, G., Cascio, M. G., Moriello, A. S., Camalli, M., Morera, E., Nalli, M., Di Marzo, V.
    European Journal of Medicinal Chemistry, vol. 43, no. 1, pp. 62-72
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  • New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain

    Ortar, G., Cascio, M. G., De Petrocellis, L., Morera, E., Rossi, F., Schiano-Moriello, A., Nalli, M., De Novellis, V., Woodward, D. F., Maione, S., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 50, no. 26, pp. 6554-6569
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  • The 1,2,3-triazole ring as a peptido- and olefinomimetic element: Discovery of click yanilloids and cannabinoids

    Appendino, G., Bacchiega, S., Minassi, A., Cascio, M. G., De Petrocellis, L., Di Marzo, V.
    Angewandte Chemie - International Edition, vol. 46, no. 48, pp. 9312-9315
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  • New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists

    Manera, C., Cascio, M. G., Benetti, V., Allarà, M., Tuccinardi, T., Martinelli, A., Saccomanni, G., Vivoli, E., Ghelardini, C., Di Marzo, V., Ferrarini, P. L.
    Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 23, pp. 6505-6510
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  • Metabolically labile cannabinoid esters: A 'soft drug' approach for the development of cannabinoid-based therapeutic drugs

    Minutolo, F., Cascio, M. G., Carboni, I., Bisogno, T., Prota, G., Bertini, S., Digiacomo, M., Bifulco, M., Di Marzo, V., Macchia, M.
    Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 17, pp. 4878-4881
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  • Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors

    Brizzi, A., Cascio, M. G., Brizzi, V., Bisogno, T., Dinatolo, M. T., Martinelli, A., Tuccinardi, T., Di Marzo, V.
    Bioorganic and Medicinal Chemistry, vol. 15, no. 16, pp. 5406-5416
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  • Structure-based virtual screening: Identification of novel CB2 receptor ligands

    Tuccinardi, T., Cascio, M. G., Di Marzo, V., Manera, C., Ortore, G., Saccomanni, G., Martinelli, A.
    Letters in Drug Design and Discovery, vol. 4, no. 1, pp. 15-19
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  • Synthesis of a potential photoactivatable anandamide analog

    Balas, L., Cascio, M. G., Marzo, V. D., Durand, T.
    Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 14, pp. 3765-3768
    Contributions to Journals: Articles
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  • Development of the first potential covalent inhibitors of anandamide cellular uptake

    Moriello, A. S., Balas, L., Ligresti, A., Cascio, M. G., Durand, T., Morera, E., Ortar, G., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 49, no. 7, pp. 2320-2332
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  • Oxyhomologues of anandamide and related endolipids: Chemoselective synthesis and biological activity

    Appendino, G., Minassi, A., Berton, L., Moriello, A. S., Cascio, M. G., De Petrocellis, L., Di Marzo, V.
    Journal of Medicinal Chemistry, vol. 49, no. 7, pp. 2333-2338
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  • Development of the first potent and specific inhibitors of endocannabinoid biosynthesis

    Bisogno, T., Cascio, M. G., Saha, B., Mahadevan, A., Urbani, P., Minassi, A., Appendino, G., Saturnino, C., Martin, B., Razdan, R., Di Marzo, V.
    Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1761, no. 2, pp. 205-212
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  • New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies

    Urbani, P., Cavallo, P., Cascio, M. G., Buonerba, M., De Martino, G., Di Marzo, V., Saturnino, C.
    Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 1, pp. 138-141
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  • Endocannabinoid metabolic pathways and enzymes

    Ligresti, A., Cascio, M. G., Di Marzo, V.
    Current Drug Targets: CNS and Neurological Disorders, vol. 4, no. 6, pp. 615-623
    Contributions to Journals: Review articles
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  • Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors

    Brizzi, A., Brizzi, V., Cascio, M. G., Bisogno, T., Sirianni, R., Marzo, V. D.
    Journal of Medicinal Chemistry, vol. 48, no. 23, pp. 7343-7350
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  • Up-regulation of the endocannabinoid system in the uterus of leptin knockout (ob/ob) mice and implications for fertility

    Maccarrone, M., Fride, E., Bisogno, T., Bari, M., Cascio, M. G., Battista, N., Finazzi Agrò, A., Suris, R., Mechoulam, R., Di Marzo, V.
    Molecular Human Reproduction, vol. 11, no. 1, pp. 21-28
    Contributions to Journals: Articles
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  • Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine

    Viganò, D., Valenti, M., Cascio, M. G., Di Marzo, V., Parolaro, D., Rubino, T.
    European Journal of Neuroscience, vol. 20, no. 7, pp. 1849-1857
    Contributions to Journals: Articles
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  • Behavioral and molecular changes elicited by acute administration of SR141716 to Δ9-tetrahydrocannabinol-tolerant rats: An experimental model of cannabinoid abstinence

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    Drug and Alcohol Dependence, vol. 74, no. 2, pp. 159-170
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  • Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain

    Valenti, M., Viganò, D., Cascio, M. G., Rubino, T., Steardo, L., Parolaro, D., Di Marzo, V.
    Cellular and Molecular Life Sciences, vol. 61, no. 7-8, pp. 945-950
    Contributions to Journals: Articles
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  • A structure-activity relationship study on N -arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase

    Cascio, M. G., Minassi, A., Ligresti, A., Appendino, G., Burstein, S., Di Marzo, V.
    Biochemical and Biophysical Research Communications, vol. 314, no. 1, pp. 192-196
    Contributions to Journals: Articles
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  • Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

    Bisogno, T., Howell, F., Williams, G., Minassi, A., Cascio, M. G., Ligresti, A., Matias, I., Schiano-Moriello, A., Paul, P., Williams, E. J., Gangadbaran, U., Hobbs, C., Di Marzo, V., Doherty, P.
    Journal of Cell Biology, vol. 163, no. 3, pp. 463-468
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • CB1 cannabinoid receptors and on-demand defense against excitotoxicity

    Marsicano, G., Goodenough, S., Monory, K., Hermann, H., Eder, M., Cannich, A., Azad, S. C., Cascio, M. G., Ortega-Gutiérrez, S., Van der Stelt, M., López-Rodríguez, M. L., Casanova, E., Schütz, G., Zieglgänsberger, W., Di Marzo, V., Behl, C., Lutz, B.
    Science, vol. 302, no. 5642, pp. 84-88
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Possible endocannabinoid control of colorectal cancer growth

    Ligresti, A., Bisogno, T., Matias, I., De Petrocellis, L., Cascio, M. G., Cosenza, V., D'Argenio, G., Scaglione, G., Bifulco, M., Sorrentini, I., Di Marzo, V.
    Gastroenterology, vol. 125, no. 3, pp. 677-687
    Contributions to Journals: Articles
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    • [ONLINE]

  • Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain

    Viganò, D., Cascio, M. G., Rubino, T., Fezza, F., Vaccani, A., Di Marzo, V., Parolaro, D.
    Neuropsychopharmacology, vol. 28, no. 6, pp. 1160-1167
    Contributions to Journals: Articles
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  • The endocannabinoid system and the molecular basis of paralytic ileus in mice.

    Mascolo, N., Izzo, A. A., Ligresti, A., Costagliola, A., Pinto, L., Cascio, M. G., Maffia, P., Cecio, A., Capasso, F., Di Marzo, V.
    The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 16, no. 14, pp. 1973-1975
    Contributions to Journals: Articles
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  • Endocannabinoids as physiological regulators of colonic propulsion in mice

    Pinto, L., Izzo, A. A., Cascio, M. G., Bisogno, T., Hospodar-Scott, K., Brown, D. R., Mascolo, N., Di Marzo, V., Capasso, F.
    Gastroenterology, vol. 123, no. 1, pp. 227-234
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