BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- 51cg
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
51cg
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
2001 PhD, Thrombosis & Vascular Biology; 51cg
1997 BSc (Hons) Molecular Biology; 51cg
Employment
2022- Cardiometabolic Disease Theme Lead, 51cg
2021- Personal Chair, 51cg
2017-2021 Reader, 51cg
2016- 2017 Senior Lecturer, 51cg
2011– 2016 British Heart Foundation Fellow, Senior Research Fellow, 51cg
2010-2011 British Heart Foundation Fellow, Lecturer, 51cg
2007-2010 Independent Research Fellow in cardiovascular medicine, University of Leeds, UK
2004-2006 Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA
Qualifications
- BSc hons Molecular Biology1997 - 51cg
- PhD Thrombosis & Vascular Biology2001 - 51cg
External Memberships
2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)
2024-2026: Vice-Chair of the Education Committee of the ISTH
2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee
2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)
2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH
2023 onwards: Steering Committee of UK Thrombosis Research Network
2024: Faculty Member of the CAS-AM course on anticoagulation management
Latest Publications
ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP
Journal of Thrombosis and HaemostasisContributions to Journals: Articles- [ONLINE] DOI:
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
Molecular MedicineContributions to Journals: Articles- [ONLINE] DOI:
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
Blood Advances, vol. 10, no. 7, pp. 2173-2181Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
European Journal of Pharmacology, vol. 1020, 178725Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Prizes and Awards
2024: ISTH Esteemed Career Award
2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis
- Research
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Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Supervision
My current supervision areas are: Biomedical Sciences.
Current PhD Students
Kieran Pocknell Co-Supervisors Dr Claire Whyte, Dr Dana Huskens (The Synapse Research Institute, The Netherlands)
- Funded by Medical Research Scotland
Jack Partridge, Co-Supervisors Dr Claire Whyte, Dr Mairead Black
- Funded by John Shivas Trust
Tarek Al Tarawni, Co-Supervisors Dr Claire Whyte, Prof Mary Joan Macleod
- Funded by Aqaba Medical Sciences University
Sara Sharaf, Principal supervisor Prof Karolin Hijazi, Co-Supervisors Prof Dana Dawson, Prof Nicola J Mutch
- Funded by Elphinstone Scholarship
Graduated PhD Students
Dr Joanne Mitchell, Funded by 51cg Development Trust and Friends of Anchor. Graduated 2016
Dr Mohammad Jalal: Funded by the Saudi Arabian Government. Graduated 2017
Dr Gael Morrow: Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood, Graduated, 2018
Dr Paraskevi Untiveros: Funded by the Chief Scientist Office. Clinical Fellow, Graduated 2018
Dr Maria-Louise Williams: Funded by the Institute of Medical Sciences, 51cg. Graduated, 2023
Dr Um-May Sumya, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2023
Dr Fahad Alshehri, Funded by Royal Embassy of Saudi Arabia Cultural Bureau, Graduated
Dr Steven Humphrey, Funded by BHF-NC3R's, Graduated 2025
Dr Anuj Narwal, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2026
Dr Madeline Rhodes, Funded by Marie-Curie Fellowship, Graduated, 2026
Funding and Grants
2026 Medical Research Scotland. Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. £147,385.31. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Dr Dana Huskens.
2026 Chief Scientist Office. Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. PI Prof NJ Mutch, Co-I, Dr Lucy de Lyold, Dr Sarah Bell, Dr Mairead Black Dr Claire Whyte, Prof Peter Collins.
2025 Heart Research UK. Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. £225,000. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog.
2025 BHF. Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. £309,764.10., PI: Dr Claire Whyte, Co-I Prof NJ Mutch, Co-I Prof Valerie Speirs
2024 BHF. S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. £289,206. PI Prof NJ Mutch, Co-I Dr Julie Rayes, Dr Claire Whyte and Dr Alexander Brill.
2024 Friends of Anchor. Development of an endothelialised model of deep vein thrombosis. PI Prof NJ Mutch, Co-I Dr Claire Whyte Mr Steven Humphreys. £15,000.
2023 Heart Research UK. Aetiology of impaired fibrinolysis in acute coronary syndrome and appropriate treatment strategies. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog. £199,970.
2022 Medical Research Scotland PhD Studentship. The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. £122,011. PI, Prof NJ Mutch Co-I Dr Claire Whyte.
2022 NC3Rs-BHF PhD studentship. Modelling of thrombus dynamics in a microfluidic ‘vasculature’. PI, Prof NJ Mutch, Co-I Dr Claire Whyte. £90,000
- Teaching
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Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
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Page 4 of 9 Results 31 to 40 of 89
Plasminogen Activator Inhibitor-1 and its cofactor vitronectin induce a hypofibrinolytic state in COVID-19 disease which correlates with disease severity.
British Society of Thrombosis and HaemostasisContributions to Conferences: Abstracts- [ONLINE]
- [ONLINE]
Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation
International Journal of Molecular Sciences, vol. 22, no. 12, 6591Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Trauma-induced coagulopathy
Nature reviews. Disease primers, vol. 7, 30Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease
Frontiers in cardiovascular medicine, vol. 8, 653655Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
International Journal of Molecular Sciences, vol. 22, no. 6, 3055Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?
International Journal of Molecular Sciences, vol. 22, no. 4, 2185Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi
International Journal of Molecular Sciences, vol. 22, no. 4, 2115Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
uPA-mediated plasminogen activation is enhanced by polyphosphate
Haematologica, vol. 106, no. 2, pp. 522-531Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets
Blood, vol. 137, no. 2, pp. 248–257Contributions to Journals: Articles- [ONLINE] DOI:
- [ONLINE]
Physiology of haemostasis: Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Moore, H., Neal, M., Moore, E. (eds.). Springer, pp. 53-74, 22 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI:
- [ONLINE]