51cg

Dr Nicholas Senn

Dr Nicholas Senn
Dr Nicholas Senn
Dr Nicholas Senn

PhD, MPhys

Research Fellow

51cg

Biography

Dr Senn graduated from the University of Sheffield in 2015 with a MPhys (Hons) in Physics with Medical Physics. He then moved to the 51cg to undertake a PhD in Medical Physics, investigating the extent translated diffusion methods can measure breast cancer cell density and tissue heterogeneity using a clinical 3T MRI system.

Following the award of his PhD in 2019, he joined the 51cg Field-cycling Imaging Group as a postdoctoral Research Fellow. Over the next 9 months he investigated novel contrast mechanisms imparted to tissue stent test objects at field strengths below 0.2 T.

Following a short career break, Dr Senn returned to the 51cg Biomedical Imaging Centre in September 2022 as a Research Fellow to investigate and develop analysis methods to examine the extent Field-cycling MRI can detect cerebral small vessel disease. To date, Dr Senn continues this work as both co-applicant and Research Fellow.

Since April 2024, Dr Senn began working within the Center for Adaptable MRI Technology (AMT Center) at Aberdeen. As a postdoctoral Research Fellow he is working towards developing 3D MR spirometry at very-low field strengths as part of the SPIRO-3D consortium lung imaging project (

In 2024, Dr Senn also launched new pilot research efforts to realise new micro imaging capabilities for MRI (ARUK Scotland Junior Member Grant) and to develop an analysis pipeline to co-register digitised microscopy images to images acquired from Field-cycling MRI (Friends of ANCHOR Pilot Research Award).

Key words: MRI; field-cycling MRI; low-field MRI; SPIRO-3d; radial imaging; micro imaging; lung; cerebral small vessel disease; breast cancer; image analysis; pulse programming

Memberships and Affiliations

Internal Memberships

Aberdeen Biomedical Imaging Centre (ABIC)

Center for Adaptable MRI Technology (AMT)

External Memberships

SINAPSE Image Analysis Theme Lead 

V|LF-Spiro3D Consortium 

Research

Knowledge Exchange

Teaching resources:

Advanced Chest MRI School 2026:

Publications

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  • Detection of cerebral small vessel disease using denoised field-cycling MRI: Book of Abstracts ESMRMB 2023

    Senn, N., Mallikourti, V., Ross, J., Broche, L., Waiter, G., Macleod, M.
    Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 36, no. Suppl 1, pp. s297
    Contributions to Journals: Abstracts
  • Automated segmentation of cerebral small vessel disease from field-cycling MRI: Proffered Conference Abstract - MIUA 2023

    Senn, N., Mallikourti, V., Ross, J., Broche, L., Waiter, G., Macleod, M.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
  • Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancer

    Chan, K., Cheung, G., Senn, N., Husain, E., Masannat, Y., Heys, S., He, J.
    BMC Cancer, vol. 22, 285
    Contributions to Journals: Articles
  • What are the factors affecting neoadjuvant chemotherapy efficacy in breast cancer?: A noninvasive in vivo histology study using specialist magnetic resonance imaging (MRI) methods

    Cheung, S. M., Wu, W., Senn, N., Sharma, R., Gagliardi, T., Husain, E., Masannat, Y., Heys, S. D., He, J.
    Contributions to Conferences: Oral Presentations
  • Peri-tumoural spatial distribution of lipid composition and tumour cellular differentiation in breast cancer

    Cheung, S. M., Chan, K., Senn, N., Husain, E., Masannat, Y., Heys, S., He, J.
    Contributions to Conferences: Oral Presentations
  • Monitoring tissue implants by field-cycling H-1-MRI via the detection of changes in the N-14-quadrupolar-peak from imidazole moieties incorporated in a "smart" scaffold material

    Bitonto, V., Di Gregorio, E., Baroni, S., Stefania, R., Aime, S., Broche, L., Senn, N., Ross, J., Lurie, D., Geninatti Crich, S.
    Journal of Materials Chemistry B, vol. 9, no. 24, pp. 4863-4872
    Contributions to Journals: Articles
  • A novel class of 1H-MRI Contrast Agents based on the relaxation enhancement induced on water protons by 14N imidazole moieties

    Baroni, S., Stefania, R., Broche, L., Senn, N., Lurie, D., Ross, J. J., Aime, S., Geninatti Crich, S.
    Angewandte Chemie International Edition, vol. 60, no. 8, pp. 4208-4214
    Contributions to Journals: Articles
  • Phased-array combination of 2D MRS for lipid composition quantification in patients with breast cancer

    Mallikourti, V., Cheung, S. M., Gagliardi, T., Senn, N., Masannat, Y., McGordlrick, T., Sharma, R., Heys, S. D., He, J.
    Scientific Reports, vol. 10, no. 1, pp. 20041
    Contributions to Journals: Articles
  • Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study

    Cheung, S. M., Keenan, K., Senn, N., Hutcheon, G., Chan, K., Erwig, L., Schrepf, A., Dospinescu, P., Gray, S., Waiter, G., He, J., Basu, N.
    Arthritis Care & Research, vol. 71, no. 12, pp. 1640-1646
    Contributions to Journals: Articles
  • q-Space Imaging Yields a Higher Effect Gradient to Assess Cellularity than Conventional Diffusion-weighted Imaging Methods at 3.0 T: A Pilot Study with Freshly Excised Whole-Breast Tumors

    Senn, N., Masannat, Y., Husain, E., Siow, B., Heys, S. D., He, J.
    Radiology: Imaging Cancer, vol. 1, no. 1, e190008
    Contributions to Journals: Articles
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