51cg

People

Dr Suzanne Breeman

Dr Suzanne Breeman
Dr Suzanne Breeman
Dr Suzanne Breeman

Senior Trial Manager

51cg
Email Address
s.breeman@abdn.ac.uk
Telephone Number
+44 (0)1224 438169
Office Address

Health Services Research Unit (HSRU)
3rd Floor, Health Sciences Building
51cg
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in October 2007 as a Trial Manager and work as the Lead Trial Manager on the following trials:

KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery

PROSPECT:  a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse. 

FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms

REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility.

I am a member of the North of Scotland Research Ethics Committee and faculty member on the Edinburgh Clinical Trial Management course (ECTMC).

I graduated with a BSc in Biochemistry (1994), a PhD in Molecular Biology (1998) and an MSc in Public Health and Health Services Research ()

Prior to joining the HSRU I worked for a biotechnology company called Auvation Limited as a Senior Scientist. 

 

Qualifications

  • BSc Biochemistry 
    1994 - 51cg 
  • PhD Molecular Biology 
    1998 - 51cg 
  • MSc Public Health and Health Services Research 
    2010 - 51cg 
Research

Research Overview

Trial management and trial methodology

Current Research

I am currently the Lead Trial Manager on the following trials:

KAT: a multi-centre randomised controlled trial to assess four developments in knee replacement surgery

PROSPECT:  a multi-centre randomised controlled trial to measure the clinical and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse 

FUTURE: a multi-centre randomised controlled trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in the managment of women with refractory overactive bladder symptoms

REGAL: multi-centre randomised controlled trial to evaluate the clinical and cost-effectiveness of long-term use of Gonadotrophin Releasing Hormone Analogues (GnRHa) with add-back hormone replacement therapy (HRT) as an alternative treatment to further laparoscopic surgery in women who present with recurrence of pain following previous surgery for endometriosis but wish to retain their fertility

Past Research

Since joining the Unit I have worked on a number of trials that have now completed:

HEALTH: a multi-centre randomised controlled trial comparing the clinical and cost effectiveness of laparoscopic supra-cervical hysterectomy (LASH) with second generation endometrial ablation (EA)

UKUFF: a multi-centre randomised controlled trial to measure the clinical and cost effectiveness of different types of management of rotator cuff repairs

PRaCTICaL: a randomised controlled trial comparing a nurse-led ICU follow-up programme versus standard care

Teaching

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course (ECTMC)

Publications

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  • Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial

    Parkes, T., Carver, H., Boyd, J., Cotton, S., Breeman, S., Cooper, D., Forrest, M., Foster, R., Hawthorn, J., Hunt, K., Kilonzo, M., Matheson, C., Maxwell, M., Mercer, S. W., Pauly, B., Scotland, G., Steele, W., Sumnall, H., Wallace, J., Macaulay, L., MacLennan, G.
    Trials, vol. 27, 18
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation

    Abdel-Fattah, M., Chapple, C., Breeman, S., Cooper, D., Bell-Gorrod, H., Kuppanda, P., Guerrero, K. L., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M., Gammie, A., Mostafa, A., Bruce, R., Bell, V., Kennedy, C., Evans, S., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 29, no. 27
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women

    Bell-Gorrod, H., Thokala, P., Breeman, S., Cooper, D., MacLennan, G., Abdel-Fattah, M., Dixon, S.
    BJU International, vol. 136, no. 1, pp. 82-94
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial

    Abdel-Fattah, M., Chapple, C., Cooper, D., Breeman, S., Bell-Gorrod, H., Kuppanda, P., Guerrero, K. L., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M. J., Gammie, A., Mostafa, A., Bruce, R., Bell, V., Kennedy, C., Evans, S., MacLennan, G., Norrie, J., FUTURE Study Group
    The Lancet, vol. 405, no. 10484, pp. 1057-1068
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • PROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse

    Reid, F. M., Aucott, L., Glazener, C. M., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R., Hagen, S., Kilonzo, M., Boyers, D., MacLennan, G., Norrie, J., Breeman, S., PROSPECT study group
    International Urogynecology Journal, vol. 34, pp. 67-78
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • How common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial

    Reid, F. M., Elders, A., Breeman, S., Freeman, R. M., Glazener, C. M., Hemming, C., Cooper, K. G., Smith, A. R., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms

    Abdel-fattah, M., Chapple, C., Guerrero, K., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M. J., Gammie, A., Mostafa, A., Bladder Health, U. K., Breeman, S., Cooper, D., MacLennan, G., Norrie, J.
    Trials, vol. 22, no. 1, 745
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • It is unprecedented: trial management during the COVID-19 pandemic and beyond

    Mitchell, E. J., Ahmed, K., Breeman, S., Cotton, S., Constable, L., Ferry, G., Goodman, K., Hickey, H., Meakin, G., Mironov, K., Quann, N., Wakefield, N., McDonald, A.
    Trials, vol. 21, pp. 784
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • How to Deal with a Temporary Suspension and Restarting Your Trial: Our Experiences and lessons Learnt

    Constable, L., Davidson, T., Breeman, S., Cotton, S., McDonald, A., Wileman, S., Norrie, J.
    Trials, vol. 21, no. 1, pp. 765
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Authors' reply re: Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

    Glazener, C. M., Breeman, S., Hagen, S., Elders, A., Aucott, L., Cooper, K., Reid, F. M.
    BJOG: An International Journal of Obstetrics and Gynaecology, vol. 127, no. 9, pp. 1170-1171
    Contributions to Journals: Comments and Debates
    • [ONLINE] DOI:
    • [ONLINE]

  • Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT)

    Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., Reid, F. M., PROSPECT study group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 127, no. 8, pp. 1002-1013
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

    Crowley, E., Treweek, S., Banister, K., Breeman, S., Constable, L., Cotton, S., Duncan, A., El Feky, A., Gardner, H., Goodman, K., Lanz, D., McDonald, A., Ogburn, E., Starr, K., Stevens, N., Valente, M., Fernie, G.
    Trials, vol. 21, no. 1, pp. 535
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Surgery for women with endometrioma prior to in vitro fertilisation: proposal for a feasible multicentre randomised clinical trial in the UK

    Maheshwari, A., Healey, J., Bhattacharya, S., Cooper, K., Saraswat, L., Horne, A. W., Daniels, J., Breeman, S., Brian, K., Burns, G., Hudson, J., Gillies, K.
    Human Reproduction Open, vol. 2020, no. 3, hoaa012
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Verifying participant-reported clinical outcomes: challenges and implications

    Breeman, S., Constable, L., Duncan, A., Starr, K., McDonald, A., Wileman, S., Cotton, S.
    Trials, vol. 21, no. 1, pp. 241
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Surgical interventions for uterine prolapse and for vault prolapse: the two VUE RCTs

    Hemming, C., Constable, L., Goulao, B., Kilonzo, M., Boyers, D., Elders, A., Cooper, K., Smith, A., Freeman, R. M., Breeman, S., McDonald, A., Hagen, S., Montgomery, I., Norrie, J., Glazener, C.
    Health Technology Assessment, vol. 24, no. 13, pp. vii-xxxi, 1-220
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Laparoscopic supracervical hysterectomy versus endometrial ablation for women with heavy menstrual bleeding (HEALTH): a parallel-group, open-label, randomised controlled trial

    Cooper, K., Breeman, S., Scott, N. W., Scotland, G., Clark, J., Hawe, J., Hawthorn, R., Phillips, K., MacLennan, G., Wileman, S., McCormack, K., Hernández, R. A., Norrie, J., Bhattacharya, S., HEALTH Study Group
    The Lancet, vol. 394, no. 10207, pp. 1425-1436
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Laparoscopic supracervical hysterectomy compared with second-generation endometrial ablation for heavy menstrual bleeding: the HEALTH RCT

    Cooper, K., Breeman, S., Scott, N. W., Scotland, G. S., Hernández, R. A., Clark, T. J., Hawe, J., Hawthorn, R., Phillips, K., Wileman, S. M., McCormack, K., Norrie, J., Bhattacharya, S.
    Health Technology Assessment, vol. 23, no. 53, pp. 1-107
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)

    Glazener, C. M. A., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R. B., Reid, F., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    The Lancet, vol. 389, no. 10067, pp. 381–392
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study

    Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K., Freeman, R., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 20, no. 95, pp. 1-452
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Two parallel, pragmatic, UK multicentre, randomised controlled trials comparing surgical options for upper compartment (vault or uterine) pelvic organ prolapse (the VUE Study): study protocol for a randomised controlled trial

    Glazener, C., Constable, L., Hemming, C., Breeman, S., Elders, A., Cooper, K., Freeman, R., Smith, A. R. B., Hagen, S., McDonald, A., McPherson, G., Montgomery, I., Kilonzo, M., Boyers, D., Goulao, B., Norrie, J.
    Trials, vol. 17, pp. 1-18
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Normative data for the Hospital Anxiety and Depression Scale

    Breeman, S., Cotton, S., Fielding, S., Jones, G. T.
    Quality of Life Research, vol. 24, no. 2, pp. 391-398
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A randomised controlled trial of the clinical effectiveness and cost-effectiveness of different knee prostheses: the Knee Arthroplasty Trial (KAT)

    Murray, D. W., MacLennan, G. S., Breeman, S., Dakin, H. A., Johnston, L., Campbell, M. K., Gray, A. M., Fiddian, N., Fitzpatrick, R., Morris, R. W., Grant, A. M., KAT group
    Health Technology Assessment, vol. 18, no. 19, pp. 1-235, vii-viii
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Five-year results of a randomised controlled trial comparing mobile and fixed bearings in total knee replacement

    Breeman, S., Campbell, M. K., Dakin, H., Fiddian, N., Fitzpatrick, R., Grant, A., Gray, A., Johnston, L., MacLennan, G. S., Morris, R. W., Murray, D. W., KAT Trial Group
    Journal of Bone & Joint Surgery (US Volume), vol. 95-B, no. 4, pp. 486-492
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial

    Cuthbertson, B. H., Rattray, J., Campbell, M. K., Gager, M., Roughton, S., Smith, A., Hull, A., Breeman, S., Norrie, J., Jenkinson, D., Hernández, R., Johnston, M., Wilson, E., Waldmann, C., PRaCTICaL Study Group
    British Medical Journal, vol. 339, b3723
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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