51cg

Dr Sergio Dall'Angelo

Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo

Ph.D. in Industrial Chemistry (Universita' Statale di Milano)

Lecturer

Accepting PhDs

51cg
Email Address
s.dallangelo@abdn.ac.uk
Telephone Number
+44 (0)1224 437563
Office Address
6.29 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition






Biography

I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.

In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University.  In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen. In May 2025 I moved to a Lecturer position.

Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.

 

Memberships and Affiliations

Internal Memberships

Member of the Concordat Steering Group

Member of the IMS Health, Safety & Wellbeing Committee

Member of Nvision Committee

IMS First Aider

External Memberships

Member of the Royal Society of Chemistry (RSC)

Member of European Society for Molecular Imaging (ESMI)

Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)  

Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics

Latest Publications

  • PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME

    Dall'Angelo, S., Hamer, M., Martin, E.
    Patents: Patents
  • A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

    Charalambous, N., Schleidt, C., Liu, R., Heitman, L. H., Dall’Angelo, S., O’Hagan, D., Lowe, P. T.
    European Journal of Organic Chemistry, vol. 29, no. 5, e202501125
    Contributions to Journals: Articles
  • Investigation into ligand selectivity and bias at the formyl peptide receptor family

    Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.
    Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764
    Contributions to Journals: Articles
  • Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents

    He, M., Thomson, C., Thompson, D., Kuodis, V., Smith, T., Dall'Angelo, S., O'hagan, D.
    ChemBioChem, vol. 26, no. 22, e202500384
    Contributions to Journals: Articles
  • Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

    Delibegovic, M., Dall'Angelo, S., Hamer, M. M., Dekeryte, R., McEwan, A. R., Greig, I.
    Patents: Patents

View My Publications

Research

Research Overview

Research interest in:

  • PET Chemistry
  • Peptide synthesis
  • Synthetic Organic Chemistry
  • Medicinal Chemistry

My research current research is focused on:

  1. the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
  2. the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
  3. the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)

I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.

Research Areas

Accepting PhDs

I am currently accepting PhDs in Chemistry, Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Chemistry

  • Supervising
  • Accepting PhDs

Biomedical Sciences

  • Supervising
  • Accepting PhDs

Research Specialisms

  • Diagnostic Imaging
  • Medicinal Chemistry
  • Applied Chemistry
  • Organic Chemistry

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Current Research

  • Development of prostate cancer PET tracers
  • [18F]FAZA and [18F]FMISO hypoxia PET imaging
  • Fluorinase mediate Fluorine-18 tracers synthesis
  • Peptide synthesis
Teaching

Courses

Publications

Page 1 of 1 Results 1 to 45 of 45

  • PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME

    Dall'Angelo, S., Hamer, M., Martin, E.
    Patents: Patents
  • A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

    Charalambous, N., Schleidt, C., Liu, R., Heitman, L. H., Dall’Angelo, S., O’Hagan, D., Lowe, P. T.
    European Journal of Organic Chemistry, vol. 29, no. 5, e202501125
    Contributions to Journals: Articles
  • Investigation into ligand selectivity and bias at the formyl peptide receptor family

    Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.
    Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764
    Contributions to Journals: Articles
  • Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents

    He, M., Thomson, C., Thompson, D., Kuodis, V., Smith, T., Dall'Angelo, S., O'hagan, D.
    ChemBioChem, vol. 26, no. 22, e202500384
    Contributions to Journals: Articles
  • Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

    Delibegovic, M., Dall'Angelo, S., Hamer, M. M., Dekeryte, R., McEwan, A. R., Greig, I.
    Patents: Patents
  • Protein tyrosine phosphatase 1B in metabolic diseases and drug development

    Delibegovic, M., Dall'Angelo, S., Dekeryte, R.
    Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378
    Contributions to Journals: Review articles
  • The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2

    Thompson, K. J., Watson, S., Zanato, C., Dall'Angelo, S., De Nooij, J. C., Pace-Bonello, B., Shenton, F. C., Sanger, H. E., Heinz, B. A., Broad, L. M., Grosjean, N., McQuillian, J. R., Dubini, M., Pyner, S., Greig, I., Zanda, M., Bleakman, D., Banks, R. W., Bewick, G. S.
    Experimental Physiology, vol. 109, no. 1, pp. 81-99
    Contributions to Journals: Articles
  • Chemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides

    Colombano, A., Dalponte, L., Dall'Angelo, S., Clemente, C., Idress, M. S., Ghazal, A., Houssen, W. E.
    Angewandte Chemie International Edition, vol. 62, no. 16, e202215979
    Contributions to Journals: Articles
  • Metal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications

    Magni, M., Dall'Angelo, S., Baldoli, C., Licandro, E., Falciola, L., Mussini, P.
    Electrochemical Science Advances, vol. 2, no. 6, e2100164
    Contributions to Journals: Articles
  • Biochemical Characterization of a Cyanobactin Arginine-N-Prenylase from the Autumnalamide Biosynthetic Pathway

    Clemente, C., Johnson, N. R., Ouyang, X., Popin, R. V., Dall'Angelo, S., Wahlsten, M., Jokela, J., Colombano, A., Nardone, B., Fewer, D. P., Houssen, W. E.
    Chemical Communications, vol. 58, no. 86, pp. 12054-12057
    Contributions to Journals: Articles
  • Guanidinoneomycin-Maleimide Molecular Transporter: Synthesis, Chemistry and Cellular Uptake

    Hadidi, K., Bellucci, M. C., Dall'Angelo, S., Leeson-Payne, A., Rochford, J. J., Esko, J. D., Tor, Y., Volonterio, A.
    Organic & Biomolecular Chemistry, vol. 19, no. 29, pp. 6513-6520
    Contributions to Journals: Articles
  • Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer

    Alwadani, B., Dall'Angelo, S., Fleming, I.
    Insights into Imaging, vol. 12, no. 1, 90
    Contributions to Journals: Articles
  • Synthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR

    Musolino, M., Fleming, I. N., Schweiger, L. F., O'hagan, D., Dall'Angelo, S., Zanda, M.
    European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439
    Contributions to Journals: Articles
  • 4,4,16-Trifluoropalmitate: design, synthesis, tritiation, radiofluorination and pre-clinical PET imaging studies on myocardial fatty acid oxidation

    Colombano, A., Dall'angelo, S., Kingston, L., Grönberg, G., Correia, C., Passannante, R., Baz, Z., Morcillo, M. A., Elmore, C., Llop, J., Zanda, M.
    ChemMedChem, vol. 15, no. 23, pp. 2317-2331
    Contributions to Journals: Articles
  • Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers

    Longo, B., Zanato, C., Piras, M., Dall'angelo, S., Windhorst, A. D., Vugts, D., Baldassarre, M., Zanda, M.
    Bioconjugate Chemistry, vol. 31, no. 9, pp. 2201-2210
    Contributions to Journals: Articles
  • Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

    Hernandez Gerez, E., Dall'angelo, S., Collinson, J. M., Fleming, I. N., Parson, S. H.
    Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593
    Contributions to Journals: Articles
  • Design, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents

    Patruno, I., Thompson, D., Dall'angelo, S., Windhorst, A. D., Vugts, D. J., Poot, A. J., Mody, N., Zanda, M.
    ChemMedChem, vol. 15, no. 16, pp. 1579-1590
    Contributions to Journals: Articles
  • Hypoxia PET/CT and Colorectal Cancer: A Case Report

    Laws, K., Murray, G. I., Kerr, K., McKiddie, F., Dall'angelo, S., Zanda, M., Fleming, I., Samuel, L.
    Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5
    Contributions to Journals: Articles
  • A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms

    Schaefer, K., Dambuza, I. M., Dall'angelo, S., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G., Gow, N. A. R.
    Microorganisms, vol. 8, no. 7, 1066
    Contributions to Journals: Articles
  • [18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging

    De Dominicis, C., Perrotta, P., Dall'angelo, S., Wyffels, L., Staelens, S., de Meyer, G. R. Y., Zanda, M.
    ACS Medicinal Chemistry Letters, vol. 11, no. 5, pp. 933-939
    Contributions to Journals: Articles
  • Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

    Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M., O'Hagan, D.
    Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486
    Contributions to Journals: Articles
  • The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)

    Tseng, C., Baillie, G., Donvito, G., Mustafa, M. A., Juola, S. E., Zanato, C., Massarenti, C., Dall'angelo, S., Harrison, W. T. A., Lichtman, A. H., Ross, R. A., Zanda, M., Greig, I. R.
    Journal of Medicinal Chemistry, vol. 62, no. 10, pp. 5049-5062
    Contributions to Journals: Articles
  • Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

    Lowe, P. T., Dall'angelo, S., Devine, A., Zanda, M., O'Hagan, D.
    ChemBioChem, vol. 19, no. 18, pp. 1969-1978
    Contributions to Journals: Articles
  • Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

    Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A., Elmore, C. S., Dawson, D., Sharma, P., Zanda, M.
    Contrast Media & Molecular Imaging, vol. 2018, 3064751
    Contributions to Journals: Articles
  • Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

    Andriu, A., Crockett, J., Dall'Angelo, S., Piras, M., Zanda, M., Fleming, I. N.
    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36
    Contributions to Journals: Articles
  • A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging

    Lowe, P. T., Dall'Angello, S., Mulder-Krieger, T., Ijzerman, A. P., Zanda, M., O'Hagan, D.
    ChemBioChem, vol. 18, no. 21, pp. 2156-2164
    Contributions to Journals: Articles
  • High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

    Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J., Zanda, M.
    ChemMedChem, vol. 12, no. 14, pp. 1142-1151
    Contributions to Journals: Articles
  • Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy

    Fernandez Diaz-Rullo, F., Zamberlan, F., Mewis, R. E., Fekete, M., Broche, L., Cheyne, L. A., Dall'Angelo, S., Duckett, S. B., Dawson, D., Zanda, M.
    Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742
    Contributions to Journals: Articles
  • Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

    Sani, M., Lazzari, P., Folini, M., Spiga, M., Zuco, V., De Cesare, M., Manca, I., Dall'Angelo, S., Frigerio, M., Usai, I., Testa, A., Zaffaroni, N., Zanda, M.
    Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850
    Contributions to Journals: Articles
  • Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

    Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A. E., Elmore, C. S., Sharma, P., Zanda, M.
    Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976
    Contributions to Journals: Articles
  • Synthesis and radio-synthesis of prospective 2-nitroimidazole hypoxia PET tracers via thiazolidine ligation with 5-fluorodeoxyribose (FDR)

    Musolino, M., Dall'angelo, S., Zanda, M.
    SynOpen, vol. 1, no. 1, pp. 173-179
    Contributions to Journals: Articles
  • Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 15, no. 9, pp. 2086-2096
    Contributions to Journals: Articles
  • Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

    Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004
    Contributions to Journals: Articles
  • NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

    Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M., Piras, M.
    Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340
    Contributions to Journals: Articles
  • Arginine Analogues Incorporating Carboxylate Bioisosteric Functions are Micromolar Inhibitors of Human Recombinant DDAH-1

    Tommasi, S., Zanato, C., Lewis, B. C., Nair, P. C., Dall'Angelo, S., Zanda, M., Mangoni, A. A.
    Organic & Biomolecular Chemistry, vol. 46, no. 13, pp. 11315-11330
    Contributions to Journals: Articles
  • An Efficient Route to N-Monosubstituted Guanidino-Lactams

    Tommasi, S., Zanato, C., Carabeo, R., Mangoni, A., Dall'Angelo, S., Zanda, M.
    Synthesis, vol. 47, no. 19, pp. 3067-3078
    Contributions to Journals: Articles
  • Pyrazole-type Cannabinoid Ligands conjugated with Fluoro-deoxy-carbohydrates as Potential PET-Imaging Agents: Synthesis and CB1/CB2 receptor affinity evaluation

    Frau, S., Dall'Angelo, S., Baillie, G. L., Ross, R. A., Pira, M., Tseng, C., Lazzari, P., Zanda, M.
    Journal of Fluorine Chemistry, vol. 152, pp. 166-172
    Contributions to Journals: Articles
  • Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor

    Dall'angelo, S., Zhang, Q., Fleming, I. N., Piras, M., Schweiger, L. F., O'Hagan, D., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558
    Contributions to Journals: Articles
  • Molecular insights into bacteroid development during Rhizobium-legume symbiosis

    Haag, A. F., Arnold, M. F. F., Myka, K. K., Kerscher, B., Dall'angelo, S., Zanda, M., Mergaert, P., Ferguson, G. P.
    FEMS Microbiology Reviews, vol. 37, no. 3, pp. 364-383
    Contributions to Journals: Articles
  • Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer

    Dall'Angelo, S., Bandaranayaka, N., Windhorst, A. D., Vugts, D., van der Born, D., Onega, M., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Nuclear Medicine and Biology, vol. 40, no. 4, pp. 464-470
    Contributions to Journals: Articles
  • [18F]-Barbiturates as PET-tracers for Alzheimer's disease

    Zanda, M., Calamai, E., Dall'Angelo, S., Koss, D., Mingarelli, M., Schweiger, L., Welch, A., Platt, B.
    245th National Spring Meeting of the American-Chemical-Society (ACS)
    Contributions to Journals: Abstracts
  • 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

    Calamai, E., Dall'Angelo, S., Koss, D., Domarkas, J., McCarthy, T. J., Mingarelli, M., Riedel, G., Schweiger, L. F., Welch, A. E., Platt, B., Zanda, M.
    Chemical Communications, vol. 49, no. 8, pp. 792-794
    Contributions to Journals: Articles
  • [18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging

    Li, X. G., Dall'Angelo, S., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemical Communications, vol. 48, no. 43, pp. 5247-5249
    Contributions to Journals: Articles
  • Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide

    Haag, A. F., Kerscher, B., Dall'Angelo, S., Sani, M., Longhi, R., Baloban, M., Wilson, H. M., Mergaert, P., Zanda, M., Ferguson, G. P.
    The Journal of Biological Chemistry, vol. 287, no. 14, pp. 10791-10798
    Contributions to Journals: Articles
  • Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis

    Haag, A. F., Baloban, M., Sani, M., Kerscher, B., Pierre, O., Farkas, A., Longhi, R., Boncompagni, E., Hérouart, D., Dall'angelo, S., Kondorosi, E., Zanda, M., Mergaert, P., Ferguson, G. P.
    PLoS Biology, vol. 9, no. 10, e1001169
    Contributions to Journals: Articles

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