Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Lecturer
- 51cg
-
- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition






Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen. In May 2025 I moved to a Lecturer position.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
- Internal Memberships
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Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
- External Memberships
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Member of the Royal Society of Chemistry (RSC)
Member of European Society for Molecular Imaging (ESMI)
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME
Patents: Patents- [ONLINE]
A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)
European Journal of Organic Chemistry, vol. 29, no. 5, e202501125Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Investigation into ligand selectivity and bias at the formyl peptide receptor family
Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents
ChemBioChem, vol. 26, no. 22, e202500384Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: Patents- [ONLINE]
- Research
-
Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.

Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
- Teaching
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Courses
Course coordinator
Coordinator
Supervisor
- Masters Research Project (LABORATORY) - MB5904
Course Co-Coordinator
Supervisor
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
- Student Selected Component 2 (ME3013)
Coordinator
Supervisor
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Masters Research Project (LABORATORY) - MB5904 MB5021
Course co-coordinator
Supervisor
- Publications
-
Page 1 of 1 Results 1 to 45 of 45
PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME
Patents: Patents- [ONLINE]
A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)
European Journal of Organic Chemistry, vol. 29, no. 5, e202501125Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Investigation into ligand selectivity and bias at the formyl peptide receptor family
Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents
ChemBioChem, vol. 26, no. 22, e202500384Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: Patents- [ONLINE]
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI:
- [ONLINE]
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental Physiology, vol. 109, no. 1, pp. 81-99Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Chemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Metal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Biochemical Characterization of a Cyanobactin Arginine-N-Prenylase from the Autumnalamide Biosynthetic Pathway
Chemical Communications, vol. 58, no. 86, pp. 12054-12057Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [OPEN ACCESS]
Guanidinoneomycin-Maleimide Molecular Transporter: Synthesis, Chemistry and Cellular Uptake
Organic & Biomolecular Chemistry, vol. 19, no. 29, pp. 6513-6520Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Insights into Imaging, vol. 12, no. 1, 90Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Synthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR
European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
4,4,16-Trifluoropalmitate: design, synthesis, tritiation, radiofluorination and pre-clinical PET imaging studies on myocardial fatty acid oxidation
ChemMedChem, vol. 15, no. 23, pp. 2317-2331Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Design, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers
Bioconjugate Chemistry, vol. 31, no. 9, pp. 2201-2210Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Design, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
ChemMedChem, vol. 15, no. 16, pp. 1579-1590Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Hypoxia PET/CT and Colorectal Cancer: A Case Report
Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms
Microorganisms, vol. 8, no. 7, 1066Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
[18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging
ACS Medicinal Chemistry Letters, vol. 11, no. 5, pp. 933-939Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)
Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)
Journal of Medicinal Chemistry, vol. 62, no. 10, pp. 5049-5062Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
- [ONLINE]
- [ONLINE]
Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging
ChemBioChem, vol. 19, no. 18, pp. 1969-1978Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters
Contrast Media & Molecular Imaging, vol. 2018, 3064751Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging
ChemBioChem, vol. 18, no. 21, pp. 2156-2164Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin
ChemMedChem, vol. 12, no. 14, pp. 1142-1151Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy
Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline
Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters
Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Synthesis and radio-synthesis of prospective 2-nitroimidazole hypoxia PET tracers via thiazolidine ligation with 5-fluorodeoxyribose (FDR)
SynOpen, vol. 1, no. 1, pp. 173-179Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers
Organic & Biomolecular Chemistry, vol. 15, no. 9, pp. 2086-2096Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers
Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting
Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Arginine Analogues Incorporating Carboxylate Bioisosteric Functions are Micromolar Inhibitors of Human Recombinant DDAH-1
Organic & Biomolecular Chemistry, vol. 46, no. 13, pp. 11315-11330Contributions to Journals: Articles- [ONLINE] DOI:
An Efficient Route to N-Monosubstituted Guanidino-Lactams
Synthesis, vol. 47, no. 19, pp. 3067-3078Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Pyrazole-type Cannabinoid Ligands conjugated with Fluoro-deoxy-carbohydrates as Potential PET-Imaging Agents: Synthesis and CB1/CB2 receptor affinity evaluation
Journal of Fluorine Chemistry, vol. 152, pp. 166-172Contributions to Journals: Articles- [ONLINE] DOI:
Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor
Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Molecular insights into bacteroid development during Rhizobium-legume symbiosis
FEMS Microbiology Reviews, vol. 37, no. 3, pp. 364-383Contributions to Journals: Articles- [ONLINE] DOI:
Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer
Nuclear Medicine and Biology, vol. 40, no. 4, pp. 464-470Contributions to Journals: Articles- [ONLINE] DOI:
[18F]-Barbiturates as PET-tracers for Alzheimer's disease
245th National Spring Meeting of the American-Chemical-Society (ACS)Contributions to Journals: Abstracts18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
Chemical Communications, vol. 49, no. 8, pp. 792-794Contributions to Journals: Articles- [ONLINE] DOI:
[18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging
Chemical Communications, vol. 48, no. 43, pp. 5247-5249Contributions to Journals: Articles- [ONLINE] DOI:
Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide
The Journal of Biological Chemistry, vol. 287, no. 14, pp. 10791-10798Contributions to Journals: Articles- [ONLINE] DOI:
Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis
PLoS Biology, vol. 9, no. 10, e1001169Contributions to Journals: Articles- [ONLINE] DOI:
