Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Lecturer
- 51cg
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- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition






Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen. In May 2025 I moved to a Lecturer position.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
- Internal Memberships
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Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
- External Memberships
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Member of the Royal Society of Chemistry (RSC)
Member of European Society for Molecular Imaging (ESMI)
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME
Patents: Patents- [ONLINE]
A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)
European Journal of Organic Chemistry, vol. 29, no. 5, e202501125Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Investigation into ligand selectivity and bias at the formyl peptide receptor family
Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents
ChemBioChem, vol. 26, no. 22, e202500384Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: Patents- [ONLINE]
- Research
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Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.

Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
- Teaching
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Courses
Course coordinator
Coordinator
Supervisor
- Masters Research Project (LABORATORY) - MB5904
Course Co-Coordinator
Supervisor
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
- Student Selected Component 2 (ME3013)
Coordinator
Supervisor
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Masters Research Project (LABORATORY) - MB5904 MB5021
Course co-coordinator
Supervisor
- Publications
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Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)
Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)
Journal of Medicinal Chemistry, vol. 62, no. 10, pp. 5049-5062Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
- [ONLINE]
- [ONLINE]
Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging
ChemBioChem, vol. 19, no. 18, pp. 1969-1978Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters
Contrast Media & Molecular Imaging, vol. 2018, 3064751Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging
ChemBioChem, vol. 18, no. 21, pp. 2156-2164Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin
ChemMedChem, vol. 12, no. 14, pp. 1142-1151Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy
Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline
Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters
Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
