51cg

Dr Sergio Dall'Angelo

Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo

Ph.D. in Industrial Chemistry (Universita' Statale di Milano)

Lecturer

Accepting PhDs

51cg
Email Address
s.dallangelo@abdn.ac.uk
Telephone Number
+44 (0)1224 437563
Office Address
6.29 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition






Biography

I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.

In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University.  In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen. In May 2025 I moved to a Lecturer position.

Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.

 

Memberships and Affiliations

Internal Memberships

Member of the Concordat Steering Group

Member of the IMS Health, Safety & Wellbeing Committee

Member of Nvision Committee

IMS First Aider

External Memberships

Member of the Royal Society of Chemistry (RSC)

Member of European Society for Molecular Imaging (ESMI)

Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)  

Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics

Latest Publications

  • PEPTIDE-BASED INHIBITORS OF PTP1B / NCK1 INTERACTION AND METHODS OF MAKING AND USING SAME

    Dall'Angelo, S., Hamer, M., Martin, E.
    Patents: Patents
  • A2A Adenosine Receptor Agonists With Last-Step Enzymatic 18F-Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

    Charalambous, N., Schleidt, C., Liu, R., Heitman, L. H., Dall’Angelo, S., O’Hagan, D., Lowe, P. T.
    European Journal of Organic Chemistry, vol. 29, no. 5, e202501125
    Contributions to Journals: Articles
  • Investigation into ligand selectivity and bias at the formyl peptide receptor family

    Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.
    Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764
    Contributions to Journals: Articles
  • Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents

    He, M., Thomson, C., Thompson, D., Kuodis, V., Smith, T., Dall'Angelo, S., O'hagan, D.
    ChemBioChem, vol. 26, no. 22, e202500384
    Contributions to Journals: Articles
  • Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

    Delibegovic, M., Dall'Angelo, S., Hamer, M. M., Dekeryte, R., McEwan, A. R., Greig, I.
    Patents: Patents

View My Publications

Research

Research Overview

Research interest in:

  • PET Chemistry
  • Peptide synthesis
  • Synthetic Organic Chemistry
  • Medicinal Chemistry

My research current research is focused on:

  1. the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
  2. the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
  3. the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)

I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.

Research Areas

Accepting PhDs

I am currently accepting PhDs in Chemistry, Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Chemistry

  • Supervising
  • Accepting PhDs

Biomedical Sciences

  • Supervising
  • Accepting PhDs

Research Specialisms

  • Diagnostic Imaging
  • Medicinal Chemistry
  • Applied Chemistry
  • Organic Chemistry

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Current Research

  • Development of prostate cancer PET tracers
  • [18F]FAZA and [18F]FMISO hypoxia PET imaging
  • Fluorinase mediate Fluorine-18 tracers synthesis
  • Peptide synthesis
Teaching

Courses

Publications

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  • Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

    Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M., O'Hagan, D.
    Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486
    Contributions to Journals: Articles
  • The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)

    Tseng, C., Baillie, G., Donvito, G., Mustafa, M. A., Juola, S. E., Zanato, C., Massarenti, C., Dall'angelo, S., Harrison, W. T. A., Lichtman, A. H., Ross, R. A., Zanda, M., Greig, I. R.
    Journal of Medicinal Chemistry, vol. 62, no. 10, pp. 5049-5062
    Contributions to Journals: Articles
  • Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging

    Lowe, P. T., Dall'angelo, S., Devine, A., Zanda, M., O'Hagan, D.
    ChemBioChem, vol. 19, no. 18, pp. 1969-1978
    Contributions to Journals: Articles
  • Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

    Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A., Elmore, C. S., Dawson, D., Sharma, P., Zanda, M.
    Contrast Media & Molecular Imaging, vol. 2018, 3064751
    Contributions to Journals: Articles
  • Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

    Andriu, A., Crockett, J., Dall'Angelo, S., Piras, M., Zanda, M., Fleming, I. N.
    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36
    Contributions to Journals: Articles
  • A New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging

    Lowe, P. T., Dall'Angello, S., Mulder-Krieger, T., Ijzerman, A. P., Zanda, M., O'Hagan, D.
    ChemBioChem, vol. 18, no. 21, pp. 2156-2164
    Contributions to Journals: Articles
  • High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

    Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J., Zanda, M.
    ChemMedChem, vol. 12, no. 14, pp. 1142-1151
    Contributions to Journals: Articles
  • Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy

    Fernandez Diaz-Rullo, F., Zamberlan, F., Mewis, R. E., Fekete, M., Broche, L., Cheyne, L. A., Dall'Angelo, S., Duckett, S. B., Dawson, D., Zanda, M.
    Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742
    Contributions to Journals: Articles
  • Synthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline

    Sani, M., Lazzari, P., Folini, M., Spiga, M., Zuco, V., De Cesare, M., Manca, I., Dall'Angelo, S., Frigerio, M., Usai, I., Testa, A., Zaffaroni, N., Zanda, M.
    Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850
    Contributions to Journals: Articles
  • Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

    Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A. E., Elmore, C. S., Sharma, P., Zanda, M.
    Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976
    Contributions to Journals: Articles
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