51cg

People

Professor Stefan Hoppler

Professor Stefan Hoppler
Professor Stefan Hoppler
Professor Stefan Hoppler

University Diploma (equiv. to MSc) in Zoology and Molecular Biology, Univ. of Zürich, Switzerland. Dr. phil. II (equiv. to Ph.D.) in Zoology, Univ. of Zürich, Switzerland

Personal Chair

51cg
Email Address
s.p.hoppler@abdn.ac.uk
Telephone Number
+44 (0)1224 437383
Office Address

UNIVERSITY OF ABERDEEN

Institute of Medical Sciences (6.22)

School of Medicine, Medical Sciences & Nutrition

Foresterhill Health Campus

ABERDEEN, AB25 2ZD, Scotland, UK

School/Department
School of Medicine, Medical Sciences and Nutrition


Biography

Born and brought up in , Switzerland. Undergraduate studies in Zoology and Molecular Biology at the , Switzerland.  Postgraduate studies in and at the in , UK with on the function of homeotic genes and wingless signalling in Drosophila midgut development. 

Postdoc with at the in , U.S.A. studying Wnt signalling in early amphibian development (Publications). Postdoct. Research Assistant with , , U.K.. Principal Investigator at , .

With the 51cg since summer 2003. Promotion to Reader (~Associate Professor) in 2006. Promotion to full Professor in 2012.

Memberships and Affiliations

Internal Memberships

Aberdeen Developmental Biology Group

Aberdeen Cardiovascular and Diabetes Centre

External Memberships

Genetics Society (committee member since 2017), Scientific Meetings Secretary (from 2021)
British Society for Developmental Biology (Committee Member 2005-2010, and Meeting Organiser 2005 and 2011)
Society for Developmental Biology (North America)
International Society for Developmental Biologists
International Society of Differentiation
Biochemical Society (UK)
Anatomical Society of Great Britain and Ireland

 

Panel Member UKRI-BBSRC Collaborative Training Collaborative Training Partnerships (CTP2) Programme Assessment Panel (2021)
BBSRC Committee C, appointed core member 2016 - 2020

 

Editorial Board of Genes (MDPI publishers) (from 2020)
Editorial Board of the journal Developmental Dynamics (2009 - 2015)
Editorial Board of the journal Hereditas (since 2015)

 

Latest Publications

  • Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition

    Torres-Aguila, N. P., Salonna, M., Shimeld, S. M., Hoppler, S., Ferrier, D. E.
    BMC Biology, vol. 24, no. 1, 28
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm

    Ross, C., Balestrini, P. A., Bates, L. E., Azami, T., Asakole, T., Semple, M., Salonna, M., Gyuris, R., Nichols, J., Fogarty, N., Hoppler, S.
    Journal of Cell Science, vol. 138, no. 18, jcs264257
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

    Giuraniuc, C. V., Zain, S., Ghafoor, S., Hoppler, S.
    Journal of Theoretical Biology, vol. 551-552, 111239
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Positive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

    Yamamoto, T., Kambayashi, Y., Otsuka, Y., Afouda, B., Giuraniuc, V., Michiue, T., Hoppler, S.
    eLife, vol. 11, 73818
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates

    Torres-Aguila, N. P., Salonna, M., Hoppler, S., Ferrier, D. E.
    Development, Growth and Differentiation, vol. 64, no. 3, pp. 120-137
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

View My Publications

Prizes and Awards

·      Royal Society/Leverhulme Senior Research Fellowship, 2020.

·      William Evans Visiting Fellowship, University of Otago, New Zealand (2011)

·      Royal Society of Edinburgh, International Exchange Fellowship (2011)

·      Wellcome Trust Research Career Development Fellowship (1997)

·      EMBO Fellowship Award (1994)

·      Max Perutz Prize for Graduate Studies (1993)

 

Research

Research Overview

The tissues and organs of developing embryos are organised by cell-to-cell signalling. These interactions are mediated by a relatively small number of signalling molecules. These signals are repeatedly used at different stages of development and in different tissues of the embryo. Wnts are one important class of such signalling molecules. They are secreted glycoproteins which function as cell-to-cell signals in develomental processes in all multicellular animals examined. Abnormally activated Wnt signalling is also involved in certain types of tumours such as breast and colon cancer.

We want to understand the normal role of Wnt signalling in patterning the developing vertebrate embryo. Where and when are Wnts used during embryogenesis and what is their function in different organs and at different stages? We have recently analysed the molecular mechanisms of tissue-specific Wnt signalling and are currently studying Wnt function in heart and brain development. We use Xenopus as our model system and apply modern techniques, such as transgenesis and antisense oligos. We also using human Embryonic Stem Cells to model the functional role of Wnt signalling in heart muscle differentiation.

Funding and Grants

 Current Grant Funding:

British Heart Foundation non-clinical studentship “Wnt Signalling Response to Myocardial Infarction”, £123,883, Aug 2020 – July 2023

BBSRC Project Grant “Diversification of Vertebrate Tcf Structure and Function”, £503,452, July 2020 – July 2023

British Heart Foundation Project Grant, Applicants: Adam Lynch and S. Hoppler, “Characterisation of a Novel Selectable Cell-Surface Regulator of Cardiovascular Progenitors for Stem Cell-Mediated Regeneration”, £196,608 Oct 2019 – Dec 2021

British Heart Foundation Programme Grant, Applicant: S. Hoppler (7.4hrs/week), "How does Wnt control gene-regulatory networks to coordinate cardiomyocyte differentiation", £1,006,869, Principal Investigator, Aug. 2018 – Jul. 2023

 

Publications

Page 1 of 1 Results 1 to 45 of 45

  • Long-read sequencing reveals increased isoform diversity in key transcription factor effectors of intercellular signalling at the invertebrate-vertebrate transition

    Torres-Aguila, N. P., Salonna, M., Shimeld, S. M., Hoppler, S., Ferrier, D. E.
    BMC Biology, vol. 24, no. 1, 28
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • WNT-mediating TCF/LEF transcription factor gene expression in early human pluripotency and cell lineages differs from the rodent paradigm

    Ross, C., Balestrini, P. A., Bates, L. E., Azami, T., Asakole, T., Semple, M., Salonna, M., Gyuris, R., Nichols, J., Fogarty, N., Hoppler, S.
    Journal of Cell Science, vol. 138, no. 18, jcs264257
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis

    Giuraniuc, C. V., Zain, S., Ghafoor, S., Hoppler, S.
    Journal of Theoretical Biology, vol. 551-552, 111239
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Positive feedback regulation of fzd7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

    Yamamoto, T., Kambayashi, Y., Otsuka, Y., Afouda, B., Giuraniuc, V., Michiue, T., Hoppler, S.
    eLife, vol. 11, 73818
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Evolutionary diversification of the canonical Wnt signaling effector TCF/LEF in chordates

    Torres-Aguila, N. P., Salonna, M., Hoppler, S., Ferrier, D. E.
    Development, Growth and Differentiation, vol. 64, no. 3, pp. 120-137
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Foxh1/Nodal Defines Context-Specific Direct Maternal Wnt/β-Catenin Target Gene Regulation in Early Development

    Afouda, B. A., Nakamura, Y., Shaw, S., Charney, R. M., Paraiso, K. D., Blitz, I. L., Cho, K. W., Hoppler, S.
    iScience, vol. 23, no. 7, 101314
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Xenopus: Experimental Access to Cardiovascular Development, Regeneration Discovery, and Cardiovascular Heart-Defect Modeling

    Hoppler, S., Conlon, F. L.
    Cold Spring Harbor perspectives in biology, vol. 12, no. 6, a037200
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies

    Mayer, C., de La Giclais, S. M., Alsehly, F., Hoppler, S.
    Genes, vol. 11, no. 5, 538
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

    Lynch, A. T., Mazzotta, S., Hoppler, S.
    Experimental Models of Cardiovascular Disease: Methods and Protocols. Ishikawa, K. (ed.). Springer, pp. 55-66, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Genome-wide transcriptomics analysis of genes regulated by GATA4, 5 and 6 during cardiomyogenesis in Xenopus laevis

    Afouda, B. A., Lynch, A. T., De Paiva Alves, E., Hoppler, S.
    Data in brief, vol. 17, pp. 559-563
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis

    Afouda, B. A., Lynch, A. T., De Paiva Alves, E., Hoppler, S.
    Developmental Biology, vol. 434, no. 1, pp. 108-120
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cardiomyocyte Differentiation from Human Embryonic Stem Cells

    Mazzotta, S., Lynch, A. T., Hoppler, S.
    Experimental Models of Cardiovascular Diseases. Ishikawa, K. (ed.). Springer, pp. 67-78, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Genome-wide analysis of canonical Wnt target gene regulation in Xenopus tropicalis challenges β-catenin paradigm

    Nakamura, Y., Hoppler, S.
    Genesis, vol. 55, no. 1-2, e22991
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development

    Mazzotta, S., Neves, C., Bonner, R. J., Bernardo, A. S., Docherty, K., Hoppler, S.
    Stem Cell Reports, vol. 7, no. 4, pp. 764-776
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • WNT and BMP regulate roadblocks toward cardiomyocyte differentiation: lessons learned from embryos inform human stem cell differentiation

    Münsterberg, A., Hoppler, S.
    Stem Cell Investigation, vol. 3, pp. 1-5
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules

    Nakamura, Y., de Paiva Alves, E., Veenstra, G. J. C., Hoppler, S.
    Development, vol. 143, no. 11, pp. 1914-1925
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Wnt signaling in the heart fields: Variations on a common theme

    Ruiz-Villalba, A., Hoppler, S., van den Hoff, M. J. B.
    Developmental Dynamics, vol. 245, no. 3, pp. 294-306
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • It's about time for neural crest

    Hoppler, S., Wheeler, G. N.
    Science, vol. 348, no. 6241, pp. 1316-1317
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling

    Afouda, B. A., Hoppler, S.
    The Genetics Society of America Conference, pp. 69
    Contributions to Journals: Abstracts
    • [ONLINE]

  • Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation

    Zylkiewicz, E., Sokol, S. Y., Hoppler, S.
    Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. Hoppler, S. P., Moon, R. T. (eds.). Wiley-Blackwell, pp. 253-266, 13 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation

    Hoppler, S., Waterman, M. L.
    Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. Wiley-Blackwell, pp. 225-237, 13 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions

    Hoppler, S. (ed.), Moon, R. T. (ed.)
    Wiley-Blackwell. 459 pages
    Books and Reports: Books
    • [ONLINE] DOI:
    • [ONLINE]

  • Wnt Signaling in Heart Organogenesis

    Hoppler, S., Mazzotta, S., Kühl, M.
    Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons Ltd., pp. 293-301, 9 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling

    Gibb, N., Lavery, D. L., Hoppler, S.
    Development, vol. 140, no. 7, pp. 1537-1549
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The Wnt signaling mediator tcf1 is required for expression of foxd3 during Xenopus gastrulation

    Janssens, S., van den Broekm, O., Davenport, I. R., Akkers, R. C., Liu, F., Veenstr, G. J. C., Hoppler, S., Vleminckx, K., Destree, O.
    International Journal of Developmental Biology, vol. 57, no. 1, pp. 49-54
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Different requirements for GATA factors in cardiogenesis are mediated by non-canonical Wnt signaling

    Afouda, B. A., Hoppler, S.
    Developmental Dynamics, vol. 240, no. 3, pp. 649-662
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Cardiac MHCα expression in Xenopus

    Hoppler, S., Afouda, B. A.
    Development, vol. 137, pp. 3-4
    Contributions to Journals: Comments and Debates
    • [ONLINE] DOI:

  • Crosstalk between Wnt and bone morphogenic protein signaling: A turbulent relationship

    Itasaki, N., Hoppler, S.
    Developmental Dynamics, vol. 239, no. 1, pp. 16-33
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:

  • Role of an aquaporin in the sheep tick Ixodes ricinus: assessment as a potential control target

    Campbell, E. M., Burdin, M., Hoppler, S., Bowman, A. S.
    International Journal for Parasitology, vol. 40, no. 1, pp. 15-23
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Wnt/β-catenin signalling regulates cardiomyogenesis via GATA transcription factors

    Martin, J., Afouda, B. A., Hoppler, S.
    Journal of Anatomy, vol. 216, no. 1, pp. 92-107
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Xenopus explants as an experimental model system for studying heart development

    Afouda, B. A., Hoppler, S.
    Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 220-226
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:

  • 13-P107 GATA transcription factors integrate Wnt signaling during heart development

    Afouda, B. A., Patient, R. K., Hoppler, S.
    Mechanisms of Development, vol. 126, no. Supplement, pp. S227
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Identification, functional characterization and expression patterns of a water-specific aquaporin in the brown dog tick, Rhipicephalus sanguineus

    Ball, A., Campbell, E. M., Jacob, J., Hoppler, S., Bowman, A. S.
    Insect Biochemistry and Molecular Biology, vol. 39, no. 2, pp. 105-112
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Inducible Gene Expression in Transient Transgenic Xenopus Embryos

    Wheeler, G., Lavery, D., Hoppler, S.
    Wnt Signaling: Volume 2, Pathway Models. Humana Press, pp. 431-449, 19 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Wnt6 signaling regulates heart muscle development during organogenesis

    Lavery, D. L., Martin, J., Turnbull, Y. D., Hoppler, S.
    Developmental Biology, vol. 323, no. 2, pp. 177-188
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Invertebrate aquaporins: a review

    Campbell, E. M., Ball, A., Hoppler, S., Bowman, A. S.
    Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, vol. 178, no. 8, pp. 935-955
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:

  • Analysis of Gene Expression in Xenopus Embryos

    Lavery, D., Hoppler, S.
    Wnt Signaling: Volume 2, Pathway Models. Vincan, E. (ed.). Humana Press, pp. 335-361, 27 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Gain-of-Function and Loss-of-Function Strategies in Xenopus

    Lavery, D., Hoppler, S.
    Wnt Signaling: Volume 2, Pathway Models. Vincan, E. (ed.). Humana Press, pp. 401-415, 15 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • Studying Wnt Signaling in Xenopus

    Hoppler, S.
    Wnt Signaling: Volume 2, Pathway Models. Vincan, E. (ed.). Humana Press, pp. 319-331, 13 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:

  • GATA transcription factors integrate Wnt signalling during heart development

    Afouda, B. A., Martin, J., Liu, F., Ciau-Uitz, A., Patient, R., Hoppler, S.
    Development, vol. 135, no. 19, pp. 3185-3190
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract

    Miller, K. A., Davidson, S., Liaros, A., Barrow, J., Lear, M., Heine, D., Hoppler, S., MacKenzie, A.
    Developmental Biology, vol. 317, no. 2, pp. 686-694
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Wnt6 expression in epidermis and epithelial tissues during Xenopus organogenesis

    Lavery, D. L., Davenport, I. R., Turnbull, Y. D., Wheeler, G. N., Hoppler, S.
    Developmental Dynamics, vol. 237, no. 3, pp. 768-779
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Distinct roles for Xenopus Tcf/Lef genes in mediating specific responses to Wnt/ß-catenin signalling in mesoderm development

    Liu, F., Van Den Broek, O., Destree, O., Hoppler, S.
    Development, vol. 132, pp. 5375-5385
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Lef-1 and Tcf-3 transcription factors mediate tissue-specific Wnt signaling during Xenopus development

    Roel, G., Hamilton, F. S., Gent, Y., Bain, A. A., Destree, O., Hoppler, S.
    Current Biology, vol. 12, no. 22, pp. 1941-1945
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Difference in XTcf-3 dependency accounts for change in response to ß-catenin-mediated Wnt signalling in Xenopus blastula

    Hamilton, F. S., Wheeler, G. N., Hoppler, S.
    Development, vol. 128, pp. 2063-2073
    Contributions to Journals: Articles

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