51cg

The Institute of Medical Sciences

Professor Nicola Mutch

In this section
Professor Nicola Mutch
Professor Nicola Mutch
Professor Nicola Mutch

BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis

Personal Chair

Accepting PhDs

51cg
Email Address
n.j.mutch@abdn.ac.uk
Telephone Number
+44 (0)1224 437492
Office Address

Lab 1.33          01224 437417

Office 5.16      01224 437492

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences

51cg

Foresterhill

Aberdeen

AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition






Biography

Education

2001                  PhD, Thrombosis & Vascular Biology; 51cg 

1997                  BSc (Hons) Molecular Biology; 51cg

Employment

2022-              Cardiometabolic Disease Theme Lead, 51cg

2021-              Personal Chair, 51cg

2017-2021      Reader, 51cg

2016- 2017     Senior Lecturer, 51cg

2011– 2016     British Heart Foundation Fellow, Senior Research Fellow, 51cg

2010-2011      British Heart Foundation Fellow, Lecturer, 51cg

2007-2010      Independent Research Fellow in cardiovascular medicine, University of Leeds, UK

2004-2006      Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA

Qualifications

  • BSc hons Molecular Biology 
    1997 - 51cg 
  • PhD Thrombosis & Vascular Biology 
    2001 - 51cg 

External Memberships

2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)

2024-2026: Vice-Chair of the Education Committee of the ISTH

2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee

2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)

2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH

2023 onwards: Steering Committee of UK Thrombosis Research Network

2024: Faculty Member of the CAS-AM course on anticoagulation management

Latest Publications

  • ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP

    Xue, Y., Roest, M., Humphreys, S. J., van der Vorm, L. N., Konings, J., Meijer, P., Whyte, C. S., de Groot, P. G., Arce, N. A., Li, R., Mutch, N. J., de Laat, B., Huskens, D.
    Journal of Thrombosis and Haemostasis
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice

    Whyte, C., Kavanagh, D., Watson, S. P., Parmer, R., Miles, L., Mutch, N.
    Molecular Medicine
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay

    Ilich, A., Whyte, C. S., Moonla, C., Berkowitz, C., Pawlinski, I., Goraya, S., Lionikiene, A. S., Jenkins, P. V., de Lloyd, L., Bell, S. F., Collis, R. E., Collins, P. W., Mutch, N. J., Key, N. S.
    Blood Advances, vol. 10, no. 7, pp. 2173-2181
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood

    Sovakova, M., Phair, I. R., Gutierrez-Lara, E., Nisr, R. B., Whyte, C. S., Smyth, D., Alqurashi, N., Yap, S., McSorley, H., Lamont, D., Mutch, N. J., McNeilly, A., Rena, G.
    European Journal of Pharmacology, vol. 1020, 178725
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment

    Humphreys, S. J., Mutch, N. J., Whyte, C. S.
    Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

View My Publications

Prizes and Awards

2024: ISTH Esteemed Career Award

2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis

Research

Research Areas

Accepting PhDs

I am currently accepting PhDs in Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Biomedical Sciences

  • Supervising
  • Accepting PhDs
View Research Area

Research Specialisms

  • Biological Sciences
  • Human Biology
  • Cardiology
  • Cell Biology
  • Immunology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Supervision

My current supervision areas are: Biomedical Sciences.

Current PhD Students

Kieran Pocknell Co-Supervisors Dr Claire Whyte, Dr Dana Huskens (The Synapse Research Institute, The Netherlands)

- Funded by Medical Research Scotland

 

Jack Partridge, Co-Supervisors Dr Claire Whyte, Dr Mairead Black

- Funded by John Shivas Trust

 

Tarek Al Tarawni, Co-Supervisors Dr Claire Whyte, Prof Mary Joan Macleod

- Funded by Aqaba Medical Sciences University

 

Sara Sharaf, Principal supervisor Prof Karolin Hijazi, Co-Supervisors Prof Dana Dawson, Prof Nicola J Mutch

- Funded by Elphinstone Scholarship

 

Graduated PhD Students

Dr Joanne Mitchell, Funded by 51cg Development Trust and Friends of Anchor. Graduated 2016

Dr Mohammad Jalal: Funded by the Saudi Arabian Government. Graduated 2017

Dr Gael Morrow: Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood, Graduated, 2018

Dr Paraskevi Untiveros: Funded by the Chief Scientist Office. Clinical Fellow, Graduated 2018

Dr Maria-Louise Williams: Funded by the Institute of Medical Sciences, 51cg. Graduated, 2023

Dr Um-May Sumya, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2023

Dr Fahad Alshehri, Funded by Royal Embassy of Saudi Arabia Cultural Bureau, Graduated

Dr Steven Humphrey, Funded by BHF-NC3R's, Graduated 2025

Dr Anuj Narwal, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2026

Dr Madeline Rhodes, Funded by Marie-Curie Fellowship, Graduated, 2026

Funding and Grants

2026    Medical Research Scotland. Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. £147,385.31.  PI Prof NJ Mutch, Co-I Dr Claire Whyte, Dr Dana Huskens.

2026    Chief Scientist Office. Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. PI Prof NJ Mutch, Co-I, Dr Lucy de Lyold, Dr Sarah Bell, Dr Mairead Black Dr Claire Whyte, Prof Peter Collins.

2025    Heart Research UK. Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. £225,000. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog.

2025    BHF. Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. £309,764.10., PI: Dr Claire Whyte, Co-I Prof NJ Mutch, Co-I Prof Valerie Speirs

2024    BHF. S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. £289,206. PI Prof NJ Mutch, Co-I Dr Julie Rayes, Dr Claire Whyte and Dr Alexander Brill.

2024    Friends of Anchor. Development of an endothelialised model of deep vein thrombosis. PI Prof NJ Mutch, Co-I Dr Claire Whyte Mr Steven Humphreys. £15,000.

2023    Heart Research UK. Aetiology of impaired fibrinolysis in acute coronary syndrome and appropriate treatment strategies. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog. £199,970.

2022    Medical Research Scotland PhD Studentship. The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. £122,011.  PI, Prof NJ Mutch Co-I Dr Claire Whyte.

2022    NC3Rs-BHF PhD studentship. Modelling of thrombus dynamics in a microfluidic ‘vasculature’.  PI, Prof NJ Mutch, Co-I Dr Claire Whyte. £90,000

Teaching

Courses

Teaching Responsibilities

Course coordinator for BM5003 Cardiovascular Health and Disease

Publications

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  • Polyphosphate co-localizes with factor XII on plateletbound fibrin and augments its plasminogen activator activity

    Mitchell, J. L., Lionikiene, A. S., Georgiev, G., Klemmer, A., Brain, C., Kim, P. Y., Mutch, N. J.
    Blood, vol. 128, no. 24, pp. 2834-2845
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network

    Whyte, C. S., Chernysh, I. N., Domingues, M. M., Connell, S., Weisel, J. W., Ariëns, R. A. S., Mutch, N. J.
    Thrombosis and Haemostasis, vol. 116, no. 5, pp. 897-903
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy

    Burley, K., Whyte, C. S., Westbury, S. K., Walker, M., Stirrups, K. E., Turro, E., Chapman, O., Reilly-Stitt, C., Mutch, N. J., Mumford, A. D.
    Blood, vol. 128, no. 14, pp. 1879-1883
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Novel aspects of platelet factor XIII function

    Mitchell, J. L., Mutch, N. J.
    Thrombosis Research, vol. 141, no. Suppl 2, pp. S17-21
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • polyphosphate co-localises with FXII on platelet-bound fibrin and markedly augments alpha FXIIa-mediated plasminogen activation

    Mitchell, J. L., Lionikiene, A. S., Georgiev, G., Klemmer, A., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 14, no. Suppl.1, pp. 39
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Plasmin-antiplasmin system

    Mutch, N. J., Booth, N. A.
    Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Polyphosphate as a haemostatic modulator

    Mutch, N. J.
    Biochemical Society Transactions, vol. 44, no. 1, pp. 18-24
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Harmonisation of D-dimer - A call for action

    Longstaff, C., Adcock, D., Olson, J. D., Jennings, I., Kitchen, S., Mutch, N., Meijer, P., Favaloro, E. J., Lippi, G., Thachil, J.
    Thrombosis Research, vol. 137, pp. 219-220
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): Communication from the SSC of the ISTH

    Foley, J. H., Kim, P. Y., Hendriks, D., Morser, J., Gils, A., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 13, no. 12, pp. 2277-2278
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)

    van der Meijden, P. E. J., Ozaki, Y., Ruf, W., de Laat, B., Mutch, N., Diamond, S., Nieuwland, R., Peters, T. C., Heestermans, M., Kremers, R. M. W., Moorlag, M., Boender, J., Ünlü, B., Reitsma, P. H.
    Thrombosis Research, vol. 136 , no. Suppl 1, pp. S3-S7
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

    Whyte, C. S., Swieringa, F., Mastenbroek, T. G., Lionikiene, A. S., Lancé, M. D., van der Meijden, P. E. J., Heemskerk, J. W. M., Mutch, N. J.
    Blood, vol. 125, no. 16, pp. 2568 - 2578
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Functional factor XIII-A is exposed on the stimulated platelet surface

    Mitchell, J. L., Lionikiene, A. S., Fraser, S. R., Whyte, C. S., Booth, N. A., Mutch, N. J.
    Blood, vol. 124, no. 26, pp. 3982–3990
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Single-chain factor XII exhibits activity when complexed to polyphosphate

    Engel, R., Brain, C. M., Paget, J., Lionikiene, A. S., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 12, no. 9, pp. 1513-1522
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

    Shaw, A., Doherty, M. K., Mutch, N. J., MacRury, S. M., Megson, I. L.
    Biochemical Society Transactions, vol. 42, no. 4, pp. 928-933
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation

    Nickel, K. F., Spronk, H. M., Mutch, N. J., Renné, T.
    Blood, vol. 122, no. 23, pp. 3847-3849
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Thrombin-anti-thrombin levels and patency of arterio-venous fistula in patients undergoing haemodialysis compared to healthy volunteers: a prospective analysis

    Milburn, J., Ford, I., Mutch, N. J., Fluck, N., Brittenden, J.
    PloS ONE, vol. 8, no. 7, e67799
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Insights into thrombin activatable fibrinolysis inhibitor function and regulation

    Foley, J. H., Kim, P. Y., Mutch, N. J., Gils, A.
    Journal of Thrombosis and Haemostasis, vol. 11, no. Suppl 1, pp. 306-315
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi

    Vercauteren, E., Mutch, N. J., Declerck, P. J., Gils, A.
    Journal of Thrombosis and Haemostasis, vol. 11, no. 1, pp. 190-192
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The Role of Platelets in Fibrinolysis

    Mutch, N. J.
    Platelets. Michelson, A. (ed.). 3 edition. Elsevier Inc, pp. 469-485, 17 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Immobilized transition metal ions stimulate contact activation and drive factor XII-mediated coagulation

    Mutch, N. J., Waters, E. K., Morrissey, J. H.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 10, pp. 2108-2115
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • "A Growing Body of Evidence Demonstrates Crosstalk Within the Haemostatic System, and It Appears That These Interconnecting Pathways Allow Fine Tuning and Balance of the Different Systems in Our Body"

    Taylor, J., Mutch, N. J.
    Circulation, vol. 125, no. 23, pp. F133-F134
    Contributions to Journals: Editorials
    • [ONLINE] DOI:

  • Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy

    Whyte, C. S., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24
    Contributions to Journals: Reviews of Books, Films and Articles
    • [ONLINE] DOI:

  • Platelet factor XIII stabilises thrombi against premature fibrin degradation

    Mutch, N. J., Fraser, S. R., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E15
    Contributions to Journals: Reviews of Books, Films and Articles
    • [ONLINE] DOI:

  • Polyphosphate scores a hat trick in regulating host defense mechanisms

    Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. 1142-1144
    Contributions to Journals: Editorials
    • [ONLINE] DOI:

  • Polyphosphate stabilises factor XIIa and acts as a cofactor in factor XIIa-mediated plasminogen activation

    Brain, C., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E13
    Contributions to Journals: Reviews of Books, Films and Articles
    • [ONLINE] DOI:

  • The antifibrinolytic function of factor XIII is exclusively expressed through a2-antiplasmin cross-linking. Blood. 2011;117(23):6371-6374.

    Fraser, S. R., Booth, N. A., Mutch, N. J.
    Blood, vol. 118, no. 26, pp. 6993
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

    Konings, J., Govers-Riemslag, J. W. P., Philippou, H., Mutch, N. J., Borissoff, J. I., Allan, P., Mohan, S., Tans, G., Ten Cate, H., Ariëns, R. A. S.
    Blood, vol. 118, no. 14, pp. 3942-3951
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Emerging roles for factor XII in vivo

    Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 9, no. 7, pp. 1355-1358
    Contributions to Journals: Editorials
    • [ONLINE] DOI:

  • The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking

    Fraser, S. R., Booth, N. A., Mutch, N. J.
    Blood, vol. 117, no. 23, pp. 6371-6374
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Platelet polyphosphate is a proinflammatory and procoagulant mediator in vivo

    Mueller, F., Mutch, N. J., Schenk, W. A., Smith, S. A., Esterl, L., Spronk, H. M., Schmidbauer, S., Gahl, W. A., Morrissey, J. H., Renne, T.
    Arteriosclerosis Thrombosis and Vascular Biology, vol. 30, no. 11, pp. E192
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

    Mutch, N. J., Koikkalainen, J. S., Fraser, S. R., Duthie, K. M., Griffin, M., Mitchell, J., Watson, H. G., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

    Baeten, K. M., Richard, M. C., Kanse, S. M., Mutch, N. J., Degen, J. L., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1313-1322
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin

    Mutch, N. J., Engel, R., Uitte de Willige, S., Philippou, H., Ariëns, R. A. S.
    Blood, vol. 115, no. 19, pp. 3980-3988
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Polyphosphate binds with high affinity to exosite II of thrombin

    Mutch, N. J., Myles, T., Leung, L. L. K., Morrissey, J. H.
    Journal of Thrombosis and Haemostasis, vol. 8, no. 3, pp. 548-555
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

    Müller, F., Mutch, N. J., Schenk, W. A., Smith, S. A., Esterl, L., Spronk, H. M., Schmidbauer, S., Gahl, W. A., Morrissey, J. H., Renné, T.
    Cell, vol. 139, no. 6, pp. 1143-1156
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots

    Mutch, N. J., Thomas, L., Moore, N. R., Lisiak, K. M., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Polyphosphate modulates blood coagulation and fibrinolysis

    Smith, S. A., Mutch, N. J., Baskar, D., Rohloff, P., Docampo, R., Morrissey, J. H.
    PNAS, vol. 103, no. 4, pp. 903-908
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI

    Mutch, N. J., Moore, N. R., Wang, E., Booth, N. A.
    Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography

    Mutch, N. J., Moir, E., Robbie, L. A., Berry, S. H., Bennett, B., Booth, N. A.
    Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003
    Contributions to Journals: Articles
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