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The School of Natural and Computing Sciences

Professor M Carmen Romano

In this section
Professor M Carmen Romano
Professor M Carmen Romano
Professor M Carmen Romano

Personal Chair

51cg
Email Address
m.romano@abdn.ac.uk
Telephone Number
+44 (0)1224 272507
Office Address
Office 337, Institute for Complex Systems and Mathematical Biology, Department of Physics, Meston Building, Old Aberdeen Office 3:47, Institute of Medical Sciences, Foresterhill
School/Department
School of Natural and Computing Sciences
Research

Research Overview

I am interested in the understanding of fundamental biological processes using theoretical approaches based on nonlinear dynamics and statistical physics and combining them with experimental data. In particular, I am interested in the process of translation or synthesis of proteins, the coupling between transcription and translation, how ribosomes, the molecular machines that manufacture proteins, are synthesised, and its relationship to the cell cycle. I am furthermore interested in the effect of combinatorial stresses in yeast, as well as the effects of different types of stress on the cell cycle.

In addition to these biological questions, I have a growing interest in the application of data science methods across disciplines, such as healthcare and the energy sector. I am particularly interested in how data-driven approaches can be used to analyse complex systems, uncover patterns, and inform decision-making in these domains.

Funding and Grants

SULSA studentship (modeling of translation)/ SABR grant (Combinatorial Responses In Stress Pathways)/BBSRC grant (Ribosome Traffic Flow on the mRNA as a Regulator of Cellular Protein Production)
Teaching

Teaching Responsibilities

Electromagnetism (PX3008, 3rd year Physics) and Introduction to Mathematics and Modelling of Biological Systems (SB5005, MSc in Cell and Molecular Systems Biology)

Publications

Page 1 of 4 Results 1 to 25 of 76

  • A Benchmark for Hallucination Detection in VLMs for Gastrointestinal Endoscopy

    Lawal, A., Oli, N., Acharya, S., Gyawali, P., Romano, M. C., Bhattarai, B.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings
    • [ONLINE] DOI:

  • Multiplicative Decomposition Model to Predict UK’s Long-Term Electricity Demand with Monthly and Hourly Resolution

    Baillon, M., Romano, M. C., Ullner, E.
    Analytics, vol. 4, no. 4, 27
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Diffusion properties of transfer RNAs in the yeast cytoplasm under normal and osmotic stress conditions

    Kompella, V. P. S., Romano, M. C., Stansfield, I., Mancera, R. L.
    Biochimica et Biophysica Acta - General Subjects, vol. 1869, 130798
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • What determines sub-diffusive behavior in crowded protein solutions?

    Kompella, V. P. S., Romano, M. C., Stansfield, I., Mancera, R. L.
    Biophysical Journal, vol. 123, no. 2, pp. 134-146
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • ExpressInHost: A codon tuning tool for the expression of recombinant proteins in host microorganisms

    Raguin, A., Stansfield, I., Romano, M. C.
    Journal of Open Research Software, vol. 11, no. 2
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Two-species totally asymmetric simple exclusion process model: From a simple description to intermittency and traveling traffic jams

    Bonnin, P., Stansfield, I., Romano, M. C., Kern, N.
    Physical Review E, vol. 105, no. 3, 034117
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

    McFarland, M. R., Keller, C. D., Childers, B. M., Adeniyi, S. A., Corrigall, H., Raguin, A., Romano, M. C., Stansfield, I.
    Nucleic Acids Research, vol. 48, no. 6, pp. 3071-3088
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [ONLINE]

  • Translational control of gene expression via interacting feedback loops

    Wang, L., Romano, M. C., Davidson, F. A.
    Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 100, no. 5, 050402(R)
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Definition Of The Minimal Contents For The Molecular Simulation Of The Yeast Cytoplasm

    Kompella, V. P. S., Stansfield, I., Romano, M. C., Mancera, R. L.
    Frontiers in Molecular Biosciences, vol. 6, 97
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Power series solution of the inhomogeneous exclusion process

    Szavits-Nossan, J., Romano, M. C., Ciandrini, L.
    Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 97, no. 5, 052139
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Deciphering mRNA Sequence Determinants of Protein Production Rate

    Szavits-Nossan, J., Ciandrini, L., Romano, M. C.
    Physical Review Letters, vol. 120, no. 12, 128101
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Novel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile

    Bonnin, P., Kern, N., Young, N. T., Stansfield, I., Romano, M. C.
    PLoS Computational Biology , vol. 13, no. 5, e1005555
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Synthetic biology routes to bio-artificial intelligence

    Nesbeth, D. N., Zaikin, A., Saka, Y., Romano, M. C., Giuraniuc, C. V., Kanakov, O., Laptyeva, T.
    Essays in Biochemistry, vol. 60, no. 4, pp. 381-391
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Identification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation

    Gorgoni, B., Ciandrini, L., McFarland, M. R., Romano, M. C., Stansfield, I.
    Nucleic Acids Research, vol. 44, no. 19, pp. 9231-9244
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans

    Chandrasekaran, K., Kaloriti, D., Tillmann, A. T., Yin, Z., Herrero De Dios, C., Jacobsen, M. D., Belmonte, R. C., Cameron, G., Haynes, K., Grebogi, C., de Moura, A. P. S., Gow, N. A. R., Thiel, M., Quinn, J., Brown, A. J. P., Romano, M. C.
    PloS ONE, vol. 10, no. 9, 0137750
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Minimal model of transcriptional elongation processes with pauses

    Wang, J., Pfeuty, B., Thommen, Q., Romano Blasco, M. C., Lefranc, M.
    Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 90, no. 5, pp. 1-4
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Ribosome recycling induces optimal translation rate at low ribosomal availability

    Marshall, E., Stansfield, I., Romano, M. C.
    Journal of the Royal Society Interface, vol. 11, no. 98, 20140589
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Stepping and Crowding of Molecular Motors: Statistical Kinetics from an Exclusion Process Perspective

    Ciandrini, L., Romano, M. C., Parmeggiani, A.
    Biophysical Journal, vol. 107, no. 5, pp. 1176-1184
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Identifying coupling directions by recurrences

    Zou, Y., Romano, M. C., Thiel, M., Kurths, J.
    Recurrence Quantification Analysis: Theory and Best Practices - Part I. Webber Jr, C. L., Marwan, N. (eds.). Springer Verlag, pp. 65-99, 35 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA

    Gorgoni, B., Marshall, E., McFarland, M. R., Romano, M. C., Stansfield, I.
    Biochemical Society Transactions, vol. 42, no. 1, pp. 160-165
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Dominant-negative release factors and their effect on termination and translational recoding events

    McFarland, M. R., Romano, M. C., Stansfield, I.
    RNA UK 2014
    Contributions to Conferences: Posters

  • The wiper model: avalanche dynamics in an exclusion process

    Politi, A., Romano, M. C.
    Journal of statistical mechanics-Theory and experiment, vol. 2013, 10015
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • From START to FINISH: the influence of osmotic stress on the cell cycle

    Radmaneshfar, E., Kaloriti, D., Gustin, M. C., Gow, N. A. R., Brown, A. J. P., Grebogi, C., Romano, M. C., Thiel, M.
    PloS ONE, vol. 8, no. 7, e68067
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Dominant-negative release factors and their effect on termination and translational recoding events

    McFarland, M. R., Romano, M. C., Stansfield, I.
    Translation UK 2013
    Contributions to Conferences: Posters

  • Ribosome traffic on mRNAs maps to gene ontology: genome-wide quantification of translation initiation rates and polysome size regulation

    Ciandrini, L., Stansfield, I., Romano, M. C.
    PLoS Computational Biology , vol. 9, no. 1, e1002866
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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