FRSE
Emeritus Professor
- 51cg
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- Email Address
- alison.murray@abdn.ac.uk
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Emerita (Radiology) with expertise in brain MRI correlates of cognitive ageing in the Aberdeen Birth Cohorts and in molecular brain imaging in TauRx clinical trials of novel therapeutics in Alzheimer's disease.
Consultant radiologist then honorary consultant NHS Grampian (1995-2020) with expertise in neuroradiology and molecular imaging.
Qualifications
- MB ChB (Hons) Medicine1985 - 51cg
- MRCP Medicine1988 - Royal College of Physicians & Surgeons of Glasgow
- FRCR Radiology1992 - Royal College of Radiologists UK
- PhD Medical Sciences2013 - 51cg
PhD Thesis November 2012 “Brain white matter hyperintensities: Correlates in normal ageing and relevance in Alzheimer’s disease.” Successfully defended January 2013
External Memberships
Fellow and council member of the Royal Society of Edinburgh
Chairperson Roland Sutton Academic Trust
Treasurer and Trustee Campaign for Evidence Based Healthcare
Trustee TENOVUS Scotland (Grampian Highlands and Islands)
Volunteer North-East Scotland Coastal Trust
Latest Publications
Brain Perivascular Space Morphometry Reflects Shared Familial Microvascular Architecture and Neuropsychiatric Influences
StrokeContributions to Journals: Articles- [ONLINE] DOI:
The Influence of Birth Weight, Socio-Economic Status, and Adult Health on Brain Volumes during Ageing
Neuroepidemiology, vol. 59, no. 5, pp. 489-497Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208Contributions to Journals: Articles- [ONLINE]
- [ONLINE] DOI:
Myelin mapping in patients with rheumatoid arthritis-related fatigue: a TBSS-MTR study of integrity
BJR Open, vol. 7, no. 1, tzaf014Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Phantom study investigating the repeatability of radiomic features with alteration of image acquisition parameters in magnetic resonance imaging
Journal of Medical Imaging and Radiation Sciences, vol. 55, no. 1, pp. 19-28Contributions to Journals: Articles- [ONLINE] DOI:
- [ONLINE]
Prizes and Awards
FRSE (2017-)
- Research
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Supervision
Dr Sima Salarirad (2011) “The relative contributions of imaging biomarkers of cerebrovascular and Alzheimer’s diseases to cognitive ageing”
Dr Moses Olufemi Sokunbi (2011) “Functional MRI entropy measurements of brain complexity”
Dr Ivan Roijals Miras (2012) “Information processing speed and information flow in the ageing brain”
Dr Dorota Chapko (2016) “Life-course determinants of resilience to cognitive ageing”
Dr Maryam Hashim (2016) 3rd supervisor “Optimisation of MRI for neuroimaging in inflammatory diseases”
Dr Maria Goni (2018) 3rd supervisor “Imaging correlates of fatigue in inflammatory disease”
Dr Clarisse De Vries – (2020) “Early life and life-course predictors of brain entropy and functional connectivity.
Dr Jennifer Waymont (2020) “Automated detection of brain lesions in the Aberdeen Children of the 1950s and analysis of lifecourse determinants”
Dr Shaun Stone (2021) “Prediction models of dementia risk from brain MR images and proxies of cognitive reserve”
Dr Mina Kherzian (2021) “Investigating the role of polypharmacy in brain ageing, and cognitive, physical and emotional impairment in three well characterised cohort studies in Aberdeen”
Dr Shailendra Mohan Tripathi (2021) “Machine learning in classification of Alzheimer’s disease diagnosis and response to treatment”
- Publications
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Page 2 of 4 Results 51 to 100 of 182
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Nature Neuroscience, vol. 21, no. 12, pp. 1656-1669Contributions to Journals: Articles- [ONLINE] DOI:
Epigenetic signatures of starting and stopping smoking
EBioMedicine, vol. 37, pp. 214-220Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Epigenetic prediction of complex traits and death
Genome Biology, vol. 19, 136Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Neurobiologic Features of Fibromyalgia Are Also Present Among Rheumatoid Arthritis Patients
Arthritis & Rheumatology, vol. 70, no. 7, pp. 1000-1007Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Cortical complexity predicts IQ
SINAPSE Annual Scientific MeetingContributions to Conferences: AbstractsA multi-modal MRI study of the central response to inflammation in rheumatoid arthritis
Nature Communications, vol. 9, 2243Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Nature Communications, vol. 9, no. 1, 2098Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Nature Genetics, vol. 50, no. 4, pp. 559-571Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
American Journal of Human Genetics, vol. 102, no. 3, pp. 375-400Contributions to Journals: Articles- [ONLINE] DOI:
Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)
International Journal of Epidemiology, vol. 47, no. 1, pp. 13-14GContributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing
Age and Ageing, vol. 47, no. 1, pp. 95-100Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [OPEN ACCESS]
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals
Circulation. Genomic and precision medicine, vol. 11, no. 1, e001758Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 10, pp. 429-437Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review
Aging & Mental Health, vol. 22, no. 8, pp. 915-926Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [OPEN ACCESS]
Neural indicators of fatigue in chronic diseases: A systematic review of MRI studies
Diagnostics, vol. 8, no. 3, 42Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly
Geriatrics, vol. 2, no. 4, 36Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Commentary on: Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment
Clinical Radiology, vol. 72, no. 11, pp. 923-924Contributions to Journals: Comments and Debates- [ONLINE] DOI:
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
Molecular Psychiatry, vol. 22, no. 10, pp. 1376-1384Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder
Biological Psychiatry, vol. 82, no. 5, pp. 312-321Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
6th Cambridge Neuroscience SymposiumContributions to Conferences: AbstractsKlotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936
Neurobiology of Aging, vol. 55, pp. 91-98Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Relationship between IQ at different ages and functional brain connectivity in healthy elders
SINAPSE Annual Scientific Meeting 2017Contributions to Conferences: Posters- [OPEN ACCESS]
Discovery of novel heart rate-associated loci using the Exome Chip
Human Molecular Genetics, vol. 26, no. 12, pp. 2346-2363Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Early Brain Development and Cognitive Ageing: A Global Challenge
Neuro CentralContributions to Journals: Comments and Debates- [ONLINE]
Sexual dimorphism in changes of cortical complexity associated with cognitive decline in late life
Alzheimer's Research UKContributions to Conferences: AbstractsA brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)
Neuroimage, vol. 144, no. Part B, pp. 299–304Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A comparison of measurement methods of hippocampal atrophy rate for predicting Alzheimer's dementia in the Aberdeen Birth Cohort of 1936
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 6, pp. 31-39Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
Translational Psychiatry, vol. 7, e1094Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study
Alzheimer Research UK (2017)Contributions to Conferences: AbstractsGenome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
Translational Psychiatry, vol. 7, 1263Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
Wellcome open research, vol. 2, pp. 1-13Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A new biomarker classification system for AD, independent of cognition: Agnosticism is a start
Neurology, vol. 87, no. 5, pp. 456-457Contributions to Journals: Editorials- [ONLINE] DOI:
Late-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936)
Age and Ageing, vol. 45, no. 4, pp. 486-493Contributions to Journals: Articles- [ONLINE] DOI:
What can imaging tell us about cognitive impairment and dementia?
World journal of radiology, vol. 8, no. 3, pp. 240-254Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late life
Archives of Gerontology and Geriatrics, vol. 63, pp. 49-54Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Cerebral correlates of cognitive reserve
Psychiatry Research, vol. 247, pp. 65-70Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis
SINAPSE Annual Scientific Meeting (2016)Contributions to Conferences: AbstractsPhenothiazine compounds for treating mild cognitive impairment
Patents: PatentsFuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span
Medical Engineering & Physics, vol. 37, no. 11, pp. 1082-1090Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A longitudinal study of cognitive and hippocampal ageing in late life
British Neuroscience Association, 2015 Festival of NeuroscienceContributions to Conferences: AbstractsAge Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure
British Journal of Medicine & Medical Research, vol. 7, no. 10, pp. 809-820Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Mapping the cortical complexity and cognitive decline in late life
Alzheimer's research UK 2015Contributions to Conferences: AbstractsPhysical disease and resilient outcomes: a systematic review of resilience definitions and study methods
Psychosomatics, vol. 56, no. 2, pp. 168-180Contributions to Journals: Articles- [ONLINE]
- [ONLINE] DOI:
Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease
Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Neural correlates of fatigue in granulomatosis with polyangiitis: a functional magnetic resonance imaging study
Rheumatology, vol. 53, no. 11, pp. 2080-2087Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort
Neuroimage, vol. 100, pp. 558-563Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Age-, and gender-specific incidence of vascular parkinsonism, progressive supranuclear palsy, and parkinsonian-type multiple system atrophy in North East Scotland: The PINE study
Parkinsonism & Related Disorders, vol. 20, no. 8, pp. 834-839Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A longitudinal study of human brain complexity and cognitive decline in ageing
Organization of Human Brain Mapping meeting (OHBM)Contributions to Conferences: Abstracts- [ONLINE]
Nonlinear complexity analysis of brain FMRI signals in schizophrenia
PloS ONE, vol. 9, no. 5, e95146Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Early Life Socioeconomic Circumstance and Late Life Brain Hyperintensities: A Population Based Cohort Study
PloS ONE, vol. 9, no. 2, e88969Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]