51cg

People

Professor Claude Wischik

Professor Claude Wischik
Professor Claude Wischik
Professor Claude Wischik

Chair in Mental Health (Clin)

51cg
Email Address
c.m.wischik@abdn.ac.uk
Office Address

TauRx Therapeutics Ltd

1st Floor, Sir Moir Lockhead Building

395 King Street

Aberdeen

AB24 5RP

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

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  • Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

    Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.
    Brain Communications, vol. 2, no. 1, fcaa033
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

    Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.
    FEBS LETTERS, vol. 594, no. 5, pp. 944-950
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

    Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

    Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.
    Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

    Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.
    International Journal of Neural Systems, vol. 29, no. 6, 1850055
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

    König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.
    ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

    Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development

    Wischik, C. M., Schelter, B. O., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
    Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

    Frahm, S., Melis, V., Horsley, D., Rickard, J., Riedel, G., Fadda, P., Scherma, M., Harrington, C., Wischik, C., Theuring, F., Schwab, K.
    Behavioural Brain Research, vol. 339, pp. 153-168
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

    Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.
    Frontiers in Molecular Neuroscience, vol. 10, 447
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

    Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

    Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks

    Shiells, H. C., Thiel, M., Wischik, C., Schelter, B.
    Medical Research Archives , vol. 5, no. 9, 1298
    Contributions to Journals: Articles
    • [ONLINE]
    • [OPEN ACCESS]

  • Organisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes

    Vuksanovic, V., Staff, R., Ahearn, T., Bentham, P., Murray, A. D., Wischik, C. M.
    6th Cambridge Neuroscience Symposium
    Contributions to Conferences: Abstracts

  • Method and system for determining network connections

    Sommerlade, L., Schelter, B., Wischik, C.
    Patents: Patents

  • LMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE

    Schwab, K., Frahm, S., Magbagbeolu, M., A. Goatman, E., R. Harrington, C., M. Wischik, C., Theuring, F.
    Alzheimer's and Dementia, vol. 13, no. 7 Suppl., pp. P945-P945
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Monoaminergic Neuropathology in Alzheimer's disease

    Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. d., Giovanni, G. D., Wischik, C. M., Hof, P. R.
    Progress in Neurobiology, vol. 151, pp. 101-138
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study

    Vuksanovic, V., Staff, R., Ahearn, T. S., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.
    Alzheimer Research UK (2017)
    Contributions to Conferences: Abstracts

  • Assays for the Screening and Characterization of Tau Aggregation Inhibitors

    Rickard, J. E., Horsley, D., Wischik, C. M., Harrington, C. R.
    Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer, pp. 129-140, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
    • [ONLINE] DOI:

  • Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

    Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    The Lancet, vol. 388, no. 10062, pp. 2873-2884
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease

    Wischik, C. M., Storey, J. M. D., Wischik, D. J., Harrington, C. R.
    Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., pp. 385-436, 52 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

    Lai, R. Y. K., Harrington, C. R., Wischik, C. M.
    Biomolecules, vol. 6, no. 2, pp. 1-19
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

    Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., Wischik, C., Hof, P. R.
    Biomolecules, vol. 6, no. 1, 6
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis

    Vuksanovic, V., Staff, R., Ahearn, T., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.
    SINAPSE Annual Scientific Meeting (2016)
    Contributions to Conferences: Abstracts

  • Phenothiazine compounds for treating mild cognitive impairment

    Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D., Staff, R. T.
    Patents: Patents

  • Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

    Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G., Theuring, F.
    Cellular and Molecular Life Sciences, vol. 72, no. 11, pp. 2199-2222
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

    Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
    Behavioural Pharmacology, vol. 26, no. 4, pp. 353-368
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

    Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.
    The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

    Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B., Luna-Muñoz, J.
    Frontiers in Neuroscience, vol. 9, 33
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

    Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A., Harrington, C. R.
    Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

    Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
    Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Tau-aggregation inhibitor therapy for Alzheimer's disease

    Wischik, C. M., Harrington, C. R., Storey, J. M. D.
    Biochemical Pharmacology, vol. 88, no. 4, pp. 529-539
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX

    Wischik, C. M., Harrington, C. R., Storey, J. M. D.
    13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, pp. S26
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents

  • Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

    Reilly, T. J., Staff, R. T., Ahearn, T. S., Bentham, P., Wischik, C. M., Murray, A. D.
    Behavioural Brain Research, vol. 222, no. 2, pp. 375-379
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease

    Staff, R., Ahearn, T. S., Phillips, L. H., Cooper, C. L., Mowat, D., Wischik, C. M., Whalley, L. J., Murray, A. D.
    Neuroscience & Medicine, vol. 2, no. 1, pp. 6-13
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
    • [OPEN ACCESS]

  • Stripline resonator and preamplifier for preclinical magnetic resonance imaging at 4.7 T

    Lavdas, I., Seton, H., Harrington, C. R., Wischik, C. M.
    Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 24, no. 6, pp. 331-337
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • 3,6-Disubstituted xanthylium salts

    Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.
    Patents: Patents

  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
    Patents: Patents

  • Ligands for aggregated tau molecules: WO2010034982

    Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.
    Patents: Patents
    • [OPEN ACCESS]

  • Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

    Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
    Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

    Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M., CC75C Collaboration Group
    The Scientific World Journal, vol. 9, pp. 1463-1475
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Therapeutic Use of Diaminophenothiazines: WO2009044127

    Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.
    Patents: Patents
    • [ONLINE]
    • [OPEN ACCESS]

  • Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

    Deiana, S., Harrington, C. R., Wischik, C. M., Riedel, G.
    Psychopharmacology, vol. 202, no. 1-3, pp. 53-65
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

    Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M., Mena, R.
    Acta Neuropathologica, vol. 116, no. 5, pp. 507-515
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Inhibitors of protein aggregation: WO2007110629

    Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.
    Patents: Patents
    • [OPEN ACCESS]

  • A55 A rCBF study of hallucinations in dementia.

    Staff, R. T., Benjamin, K. D., Murray, A. D., Gemmell, H. G., Wischik, C. M.
    Nuclear Medicine Communications, vol. 27, no. 3, 295
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

    Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.
    Patents: Patents
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