51cg

People

Dr Claire Whyte

Dr Claire Whyte
Dr Claire Whyte
Dr Claire Whyte

PhD, AFHEA

Advanced Research Fellow

51cg
Email Address
c.s.whyte@abdn.ac.uk
Telephone Number
+44 (0)1224 437897
Office Address

Lab 1.33 Office 3.47:6

Institute of Medical Sciences

School/Department
School of Medicine, Medical Sciences and Nutrition


Biography

I am an Advanced Research Fellow at the Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Science. I obtained my PhD in Medical Sciences at Rowett Research Institute of Nutrition and Health through the 51cg. My research to date has focused on cellular regulation of fibrinolysis with a particular interest in the role of platelets in directing this process. I have also investigated fibrinolytic dysregulation in disease situations including COVID-19, DVT and stroke.  I was the first recipient of Friends of Anchor's Transition to Independence Fellowship and I am currently funded by the British Heart Foundation to investigate dysregulated fibrinolysis in cancer associated thrombosis.

Qualifications

  • PhD Medical Sciences 
    2009 - 51cg 

Memberships and Affiliations

Internal Memberships

University Research Committee - ECR Representative

Nvision Researcher Development Network Committee

Postdoctoral Research Committee - Institute of Medical Sciences Representative 

School of Medicine, Medical Sciences & Nutrition Health and Safety Committee - ECR Representative

External Memberships

British Society for Haemostasis and Thrombosis Committee 

Vice-Chair - International Society for Fibrinolysis and Proteolysis

Membership Committee - International Society on Thrombosis and Haemostasis

Latest Publications

  • ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP

    Xue, Y., Roest, M., Humphreys, S. J., van der Vorm, L. N., Konings, J., Meijer, P., Whyte, C. S., de Groot, P. G., Arce, N. A., Li, R., Mutch, N. J., de Laat, B., Huskens, D.
    Journal of Thrombosis and Haemostasis
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice

    Whyte, C., Kavanagh, D., Watson, S. P., Parmer, R., Miles, L., Mutch, N.
    Molecular Medicine
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood

    Sovakova, M., Phair, I. R., Gutierrez-Lara, E., Nisr, R. B., Whyte, C. S., Smyth, D., Alqurashi, N., Yap, S., McSorley, H., Lamont, D., Mutch, N. J., McNeilly, A., Rena, G.
    European Journal of Pharmacology, vol. 1020, 178725
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cancer-Associated Thrombosis (CAT); mechanisms and treatment options

    Alshehri, F. S., Alloghbi, A., Alshalani, A., Sabah, H. A., Whyte, C. S.
    Thrombosis Journal, vol. 23, no. 1, 116
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment

    Humphreys, S. J., Mutch, N. J., Whyte, C. S.
    Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

View My Publications

Prizes and Awards

D. Collen Young Investigator Award  runner up 2023

D. Collen Young Investigator Award  runner up 2018

Research

Supervision

Previous PhD students (second supervisor):

Dr Joanne Mitchell

Dr Gael Morrow

Dr Fahad Alshehri

Dr Steven Humphreys

Dr Anuj Narwal

Supervisees

  • MR KIERAN POCKNELL
  • DR TAREQ AL TARAWNI
  • MR JACK PARTRIDGE

Funding and Grants

Current Funding as Principal Investigator:

Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. The British Heart Foundation. Co-Investigators Prof Valerie Speirs and Prof Nicola Mutch.

Current Funding as Co-Investigator:

Bleeding after childbirth – exploring abnormal blood clotting and how to treat it.  Chief Scientist Office. PI: Prof Nicola J Mutch. Co-I Dr Mairead Black, Dr  Lucy De Lloyd, Prof Peter Collins, Dr Sarah Bell.

Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. Medical Research Scotland.   PI: Prof Nicola J Mutch. Co-I Dr Dana Huskens.

Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. Heart Research UK. PI: Prof Nicola Mutch. Co-I Prof Diana Gorog.

S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. The British Heart Foundation. PI: Prof Nicola J Mutch, Co-Is Dr Julie Rayes and Dr Alexander Brill.

The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. Medical Research Scotland.  PI: Prof Nicola Mutch.

Teaching

Courses

Publications

Page 1 of 1 Results 1 to 34 of 34

  • ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP

    Xue, Y., Roest, M., Humphreys, S. J., van der Vorm, L. N., Konings, J., Meijer, P., Whyte, C. S., de Groot, P. G., Arce, N. A., Li, R., Mutch, N. J., de Laat, B., Huskens, D.
    Journal of Thrombosis and Haemostasis
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice

    Whyte, C., Kavanagh, D., Watson, S. P., Parmer, R., Miles, L., Mutch, N.
    Molecular Medicine
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood

    Sovakova, M., Phair, I. R., Gutierrez-Lara, E., Nisr, R. B., Whyte, C. S., Smyth, D., Alqurashi, N., Yap, S., McSorley, H., Lamont, D., Mutch, N. J., McNeilly, A., Rena, G.
    European Journal of Pharmacology, vol. 1020, 178725
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cancer-Associated Thrombosis (CAT); mechanisms and treatment options

    Alshehri, F. S., Alloghbi, A., Alshalani, A., Sabah, H. A., Whyte, C. S.
    Thrombosis Journal, vol. 23, no. 1, 116
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment

    Humphreys, S. J., Mutch, N. J., Whyte, C. S.
    Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V

    Collins, P. W., Whyte, C., de Lloyd, L., Narwal, A., Bell, S. F., Gill, N., Collis, R. E., Jenkins, P. V., Mutch, N.
    Blood Advances, vol. 9, no. 11, pp. 2751-2762
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation

    Sang, Y., Lee, R. H., Luong, A., Katona, ?., Whyte, C. S., Smith, N. L., Mast, A. E., Flick, M. J., Mutch, N. J., Bergmeier, W., Wolberg, A. S.
    Blood Advances, vol. 8, no. 19, pp. 5072–5085.
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Fibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)

    Simpson, M., Narwal, A., West, E., Martin, J., Bagot, C. N., Page, A. R., Watson, H. G., Whyte, C. S., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Novel therapeutics and emerging technology in haemostasis and thrombosis: highlights from the British society for haemostasis and thrombosis annual meeting

    Whyte, C. S., Morrow, G. B., Gauer, J. S., Montague, S. J., Nicolson, P. L. R.
    Frontiers in cardiovascular medicine, vol. 10, 1225243.
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

    Mitchell, J. L., Little, G., Bye, A. P., Gaspar, R. S., Unsworth, A. J., Kriek, N., Sage, T., Stainer, A., Sangowawa, I., Morrow, G. B., Bastos, R. N., Shapiro, S., Desborough, M. J., Curry, N., Gibbins, J. M., Whyte, C. S., Mutch, N. J., Jones, C. I.
    Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 5, 100200
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • All tangled up: interactions of the fibrinolytic and innate immune systems

    Whyte, C.
    Frontiers in Medicine, vol. 10, 1212201
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Editorial: Women in Thrombosis

    Whyte, C., Panova-Noeva, M.
    Frontiers in cardiovascular medicine, vol. 10, 1159938
    Contributions to Journals: Editorials
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi

    Narwal, A., Whyte, C. S., Mutch, N. J.
    Contributions to Journals: Short Survey
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • “Going with the flow” in modeling fibrinolysis

    Whyte, C. S., Mutch, N. J.
    Frontiers in cardiovascular medicine, vol. 9, 1054541
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • COVID-19 disease is associated with a hypofibrinolytic state driven by elevated plasminogen activator inhibitor-1 and its cofactor vitronectin.

    Simpson, M., Whyte, C., Morrow, G. B., Wallace, C., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J., Mutch, N.
    International Society of Thrombosis and Haemostasis, PB0605
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

    Whyte, C. S., Simpson, M., Morrow, G. B., Wallace, C. A., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J. G., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 20, no. 10, pp. 2394-2406
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Plasminogen Activator Inhibitor-1 and its cofactor vitronectin induce a hypofibrinolytic state in COVID-19 disease which correlates with disease severity.

    Simpson, M., Whyte, C., Morrow, G. B., Wallace, C., Mentzer, A. J., Knight, J. C., Shapiro, S., Curry, N., Bagot, C. N., Watson, H., Cooper, J., Mutch, N.
    British Society of Thrombosis and Haemostasis
    Contributions to Conferences: Abstracts
    • [ONLINE]
    • [ONLINE]

  • A serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease

    Morrow, G. B., Whyte, C., Mutch, N. J.
    Frontiers in cardiovascular medicine, vol. 8, 653655
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

    Alshehri, F. S. M., Whyte, C., Mutch, N.
    International Journal of Molecular Sciences, vol. 22, no. 6, 3055
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • uPA-mediated plasminogen activation is enhanced by polyphosphate

    Whyte, C. S., Mutch, N. J.
    Haematologica, vol. 106, no. 2, pp. 522-531
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Exposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets

    Whyte, C. S., Morrow, G. B., Baik, N., Booth, N. A., Jalal, M. M., Parmer, R., Miles, L., Mutch, N. J.
    Blood, vol. 137, no. 2, pp. 248–257
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Physiology of haemostasis: Plasmin-antiplasmin system

    Mutch, N. J., Whyte, C. S.
    Trauma Induced Coagulopathy. Moore, H., Neal, M., Moore, E. (eds.). Springer, pp. 53-74, 22 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency

    Westbury, S. K., Whyte, C. S., Stephens, J., Downes, K., Turro, E., Claesen, K., Mertens, J. C., Hendriks, D., Latif, A., Leishman, E. J., NIHR BioResource, Mutch, N. J., Campbell Tait, R., Mumford, A. D.
    Journal of Thrombosis and Haemostasis, vol. 18, no. 9, pp. 2209-2214
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

    Whyte, C. S., Morrow, G. B., Mitchell, J. L., Chowdary, P., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 18, no. 7, pp. 1548-1555
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation

    Morrow, G., Whyte, C. S., Mutch, N. J.
    Haematologica, vol. 105, no. 5
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Platelet-Mediated Modulation of Fibrinolysis

    Whyte, C. S., Mitchell, J. L., Mutch, N. J.
    Seminars in Thrombosis and Hemostasis, vol. 43, no. 2, pp. 115-128
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network

    Whyte, C. S., Chernysh, I. N., Domingues, M. M., Connell, S., Weisel, J. W., Ariëns, R. A. S., Mutch, N. J.
    Thrombosis and Haemostasis, vol. 116, no. 5, pp. 897-903
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy

    Burley, K., Whyte, C. S., Westbury, S. K., Walker, M., Stirrups, K. E., Turro, E., Chapman, O., Reilly-Stitt, C., Mutch, N. J., Mumford, A. D.
    Blood, vol. 128, no. 14, pp. 1879-1883
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

    Whyte, C. S., Swieringa, F., Mastenbroek, T. G., Lionikiene, A. S., Lancé, M. D., van der Meijden, P. E. J., Heemskerk, J. W. M., Mutch, N. J.
    Blood, vol. 125, no. 16, pp. 2568 - 2578
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Functional factor XIII-A is exposed on the stimulated platelet surface

    Mitchell, J. L., Lionikiene, A. S., Fraser, S. R., Whyte, C. S., Booth, N. A., Mutch, N. J.
    Blood, vol. 124, no. 26, pp. 3982–3990
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo

    Arnold, C. E., Whyte, C. S., Gordon, P., Barker, R. N., Rees, A. J., Wilson, H. M.
    Immunology, vol. 141, no. 1, pp. 96-110
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • N-3 long-chain polyunsaturated fatty acids inhibit smooth muscle cell migration by modulating urokinase plasminogen activator receptor through MEK/ERK-dependent and -independent mechanisms

    Whyte, C., Thies, F., Peyrol, L., Balcerzak, D.
    The Journal of Nutritional Biochemistry, vol. 23, no. 11, pp. 1378-1383
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy

    Whyte, C. S., Mutch, N. J.
    Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24
    Contributions to Journals: Reviews of Books, Films and Articles
    • [ONLINE] DOI:

  • Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

    Whyte, C. S., Bishop, E. T., Rückerl, D., Gaspar-Pereira, S., Barker, R. N., Allen, J. E., Rees, A. J., Wilson, H. M.
    Journal of Leukocyte Biology, vol. 90, no. 5, pp. 845-854
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

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