51cg

People

Dr Carl Counsell

Dr Carl Counsell
Dr Carl Counsell
Dr Carl Counsell

MRCP, MSc, MD

Reader (Clinical)

51cg
Email Address
carl.counsell@abdn.ac.uk
Office Address

Room 1:009, Polwarth Building Division of Applied Health Sciences 51cg Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Carl is a clinical reader and honorary consultant in neurology.  He graduated in medicine from Cambridge University in 1988, did his early postgraduate medical training in London, Newcastle and Falkirk and then trained in neurology, stroke and epidemiology in Edinburgh.  He spent a year in Melbourne where he specialised in movement disorders before taking up his present post in 2001.  A committed Christian, he would like to have more time to serve in his church and develop his interests in Fairtrade and conservation. 

Latest Publications

  • Personalised prediction of institutionalisation in Parkinson’s: prognostic factor identification and model development and validation using IPD meta-analysis

    Li, Y., McLernon, D., Lawson, R. A., Yarnall, A. J., Bäckström, D., Forsgren, L., Camacho, M., Williams-Gray, C. H., Maple-Grodem, J., Alves, G., Tysnes, O., Counsell, C., MacLeod, A., Parkinson’s Incidence Cohorts Collaboration
    Parkinsonism and Related Disorders, vol. 149, 108390
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Prognosis in Parkinson’s disease: an individual-patient-data meta-analysis of six European incidence cohorts

    MacLeod, A., McLernon, D., Camacho, M., Williams-Gray, C. H., Lawson, R. A., Yarnall, A. J., Bäckström, D., Forsgren, L., Maple-Grødem, J., Alves, G., Tysnes, O., Counsell, C., Parkinson’s Incidence Cohorts Collaboration
    Movement Disorders, vol. 41, no. 7, pp. 1798-1811
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Multi-locus genetic dosage shapes cognitive disease progression in Parkinson’s patients: 15-year meta-analysis of 24 cohorts

    Kang, X., Lin, Z., Calikusu, F. Z., Miller, L. A., Soriano, S., Locascio, J. J., Corvol, J., Maple-Grødem, J., Fan, Y., Mead, K., Campbell, M. C., Elbaz, A., Lesage, S., Brice, A., Hung, A. Y., Schwarzschild, M. A., Hayes, M. T., Wills, A., Herrington, T. M., Liu, G., Ravina, B., Taba, P., Kõks, S., Simuni, T., Forsgren, L., Counsell, C., Macleod, A. D., Beach, T. G., Alves, G., Tysnes, O., Perlmutter, J. S., Heutink, P., Kasten, M., Mollenhauer, B., Trenkwalder, C., Klein, C., Hepp, D. H., Backstrom, D., Svenningsson, P., Hu, M. T., Williams-Gray, C. H., Barker, R. A., Scherzer, C. R., International Genetics of Parkinson Disease Progression (IGPP) Consortium
    npj Parkinson's Disease
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Digitally enabled therapy for chronic tic disorders and Tourette Syndrome: a systematic review and economic evaluation

    Boyers, D., Cruickshank, M., Azharuddin, M., Manson, P., Swallow, D., Counsell, C., Brazzelli, M.
    Health Technology Assessment, vol. 30, no. 8
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Systematic review of prognostic models in Parkinson’s disease

    Li, Y., McDonald-Webb, M., McLernon, D., Counsell, C., MacLeod, A.
    npj Parkinson's Disease, vol. 11, 266
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

View My Publications

Research

Research Overview

Carl is a consultant neurologist with subspecialty interest in movement disorders.  His main research interests are in evidence-based medicine and broader aspects of clinical epidemiology such as incidence and prognostic studies, particularly in relation to Parkinson's disease, other movement disorders and stroke.  His team have established several cohorts of parkinsonian patients for long-term follow-up and supported a number of non-industry sponsored clinical trials and Cochrane reviews, whilst also trying to promote multidisciplinary neurology research in Aberdeen. 

Research Specialisms

  • Clinical Medicine

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Current Research

The PINE study: a population-based incidence cohort of people with Parkinson's disease and other parkinsonian disorders, along with their carers and controls who are being followed up lifelong to establish long-term prognosis.

The Parkinson's Incidence Cohorts Collaboration:  an individual patient data meta-analysis of all population- based incidence cohorts of Parkinson's disease to assess prognosis and allow prognostic modelling.     

The Scottish PSP/CBD prevalence cohort:  a cohort of people with two related Parkinson's plus disorders,  Progressive Supranuclear Palsy and Corticobasal Degeneration as well as Parkinson's disease controls, to assess diagnostic and care pathways and prognosis.  

 

Past Research

Cochrane systematic reviews of randomised trials in stroke care and Parkinson's disease

Prognostic modelling in acute stroke

Incidence of Parkinson's disease and other parkinsonian disorders in North-East Scotland 

Prevalence of multiple sclerosis in North-East Scotland and northern isles

Randomised trial of physiotherapy for cervical dystonia

 

Knowledge Exchange

Member of Parkinson's Excellence Network

Collaborations

Cochrane Collaboration Stroke Review Group, Professors Charles Warlow and Peter Sandercock, University of Edinburgh, UK, 1993-98.

Scottish Audit of Intracranial Vascular Malformations, Professor Rustam Al-Shahi Salman, University of Edinburgh, UK, 2002-2014. 

PDMED trial, Professor Carl Clarke, University of Birmingham, UK, 2004-2020.

Clinical trial methods in neurodegenerative diseases, Professor John Zajicek, University of Plymouth, UK, 2009-2014. 

PDCOMM trial, Professor Sackley, University of Nottingham, UK, 2016-2023.

NICE technology appraisals for multiple sclerosis, Universities of Warwick and Exeter, UK, 2016-2022 

Parkinson's Incidence Cohorts Collaboration, Professor Tysnes, Dr Guido Alves, Professor Lars Forsgren, Dr Caroline Williams-Gray, Dr Alison Yarnall, Universities of Stavanger (Norway), Umea (Sweden), Cambridge (UK) and Newcastle (UK), 2018 ongoing 

PD Connect exercise trial, Julie Jones, Robert Gordon University, Aberdeen, UK, 2019-2022 

 

Supervision

Dr Kate Taylor (MD), 2002-06, Incidence and prognosis of parkinsonism in north-east Scotland: a pilot study.

Clare Harris (MSc), 2006-08, PINE participants attitudes to brain donation. 

Dr Robert Caslake (PhD), 2006-11, Incidence and short-term prognosis of Parkinson's disease and other parkinsonian disorders in north-east Scotland.

Dr Elizabeth Visser (MD), 2009-13, Prevalence of multiple sclerosis in northern Scotland.

Dr David McGhee (PhD), 2009-13, Improving clinical trial design in neurodegenerative diseases.

Dr Angus Macleod (PhD), 2012-15, Predicting mortality and dependency in Parkinson's disease.

Dr Diane Swallow (PhD), 2016-21, Assessing diagnostic pathways in progressive supranuclear palsy and corticobasal degeneration.

Funding and Grants

Research funding has been obtained from:

Parkinson’s UK, Scottish Chief Scientist Office, BMA Doris Hillier award, RS Macdonald Trust, BUPA Foundation, NHS Grampian endowments, Dystonia Society, National Institute for Health Research.  

Teaching

Teaching Responsibilities

Lectures and clinical teaching of neurology for medical and dental students.

Supervising medical student elective and MSc projects 

Non-course Teaching Responsibilities

Regent to medical students

Publications

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  • Association of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease

    Maple-Grødem, J., Dalen, I., Tysnes, O., MacLeod, A. D., Forsgren, L., Counsell, C. E., Alves, G.
    Neurology, vol. 96, no. 7, pp. e1036-e1044
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients

    Szwedo, A. A., Pedersen, C. C., Ushakova, A., Forsgren, L., Tysnes, O., Counsell, C. E., Alves, G., Lange, J., Macleod, A. D., Maple-Grødem, J.
    Frontiers in Neurology, vol. 11, 620585
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Accuracy of death certificates for recording parkinsonian syndromes and associated dementia

    Shi, H., Counsell, C.
    Journal of Neurology, vol. 268, pp. 140–146
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease

    Ramsay, N., MacLeod, A. D., Alves, G., Camacho, M., Forsgren, L., Lawson, R. A., Maple-Grødem, J., Tysnes, O., Williams-Gray, C. H., Yarnall, A. J., Counsell, C. E., Parkinson’s Incidence Cohorts Collaboration
    Parkinsonism & Related Disorders, vol. 76, pp. 49-53
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Ocrelizumab for Treating Patients with Primary Progressive Multiple Sclerosis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

    Auguste, P., Colquitt, J., Connock, M., Loveman, E., Court, R., Ciccarelli, O., Counsell, C., Armoiry, X.
    Pharmacoeconomics, vol. 38, no. 6, pp. 527-536
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Treatment Responsiveness of Motor Features in Parkinson's Disease: A Matched Case‐Control Analysis

    MacLeod, A. D., Counsell, C. E.
    Movement Disorders Clinical Practice, vol. 7, no. 1, pp. 45-51
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages

    Melendez-Torres, G. J., Armoiry, X., Court, R., Patterson, J., Kan, A., Auguste, P., Madan, J., Counsell, C., Ciccarelli, O., Clarke, A.
    BMC Neurology, vol. 18, 162
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Age-related selection bias in Parkinson's disease research: are we recruiting the right participants?

    MacLeod, A. D., Henery, R., Nwajiugo, P. C., Scott, N. W., Caslake, R., Counsell, C. E.
    Parkinsonism & Related Disorders, vol. 55, pp. 128-133
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease

    Lunde, K. A., Chung, J., Dalen, I., Pedersen, K. F., Linder, J., Domellöf, M. E., Elgh, E., MacLeod, A., Tzoulis, C., Larsen, J. P., Tysnes, O., Forsgren, L., Counsell, C. E., Alves, G., Maple-Grødem, J.
    Alzheimer's and Dementia, vol. 14, no. 10, pp. 1293-1301
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Author response: Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study

    MacLeod, A. D., Myint, P. K., Counsell, C. E.
    Neurology, vol. 91, no. 6, pp. 287-287
    Contributions to Journals: Comments and Debates
    • [ONLINE] DOI:

  • Short and long-term clinical outcomes of use of beta-interferon or glatiramer acetate for people with clinically isolated syndrome: a systematic review of randomised controlled trials and network meta-analysis

    Armoiry, X., Kan, A., Melendez-Torres, G. J., Court, R., Sutcliffe, P., Auguste, P., Madan, J., Counsell, C., Clarke, A.
    Journal of Neurology, vol. 265, no. 5, pp. 999-1009
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Author response: Early weight loss in neurodegenerative disorders could be related to increased protein metabolism in the brain

    MacLeod, A. D., Myint, P. K., Counsell, C. E.
    Neurology
    Contributions to Journals: Comments and Debates
    • [ONLINE]

  • Development and validation of prognostic survival models in newly diagnosed Parkinson’s disease

    Macleod, A. D., Dalen, I., Tysnes, O., Larsen, J. P., Counsell, C. E.
    Movement Disorders, vol. 33, no. 1, pp. 108-116
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Early weight loss in parkinsonism predicts poor outcomes: evidence from an incident cohort study

    Cumming, K., MacLeod, A., Myint, P. K., Counsell, C. E.
    Neurology, vol. 89, no. 22, pp. 2254-2261
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Season of infectious mononucleosis as a risk factor for multiple sclerosis: a UK primary care case-control study

    Downham, C., Visser, E., Vickers, M., Counsell, C.
    Multiple Sclerosis and Related Disorders, vol. 17, pp. 103-106
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Clinical effectiveness and cost-effectiveness of beta-interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation

    Melendez-Torres, G. J., Auguste, P., Armoiry, X., Maheswaran, H., Court, R., Madan, J., Kan, A., Lin, S., Counsell, C., Patterson, J., Rodrigues, J., Ciccarelli, O., Fraser, H., Clarke, A.
    Health Technology Assessment, vol. 21, no. 52, pp. 1-352
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

    Witoelar, A., Jansen, I. E., Wang, Y., Desikan, R. S., Gibbs, J. R., Blauwendraat, C., Thompson, W. K., Hernandez, D. G., Djurovic, S., Schork, A. J., Bettella, F., Ellinghaus, D., Franke, A., Lie, B. A., McEvoy, L. K., Karlsen, T. H., Lesage, S., Morris, H. R., Brice, A., Wood, N. W., Heutink, P., Hardy, J., Singleton, A. B., Dale, A. M., Gasser, T., Andreassen, O. A., Sharma, M., Nalls, M. A., Plagnol, V., Sheerin, U. M., Saad, M., Simon-Sanchez, J., Schulte, C., Sveinbjornsdottir, S., Arepalli, S., Barker, R., Ben-Shlomo, Y., Berendse, H. W., Berg, D., Bhatia, K., De Bie, R. M., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Bras, J. M., Brockmann, K., Brooks, J., Burn, D. J., Counsell, C., International Parkinson's Disease Genomics Consortium (IPDGC), United Kingdom Brain Expression Consortium (UKBEC) Investigators, North American Brain Expression Consortium (NABEC)
    JAMA Neurology, vol. 74, no. 7, pp. 780-792
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Simple prediction scores predict good and devastating outcomes after stroke more accurately than physicians

    Reid, J. M., Dai, D., Delmonte, S., Counsell, C., Phillips, S. J., Macleod, M. J.
    Age and Ageing, vol. 46, no. 3, pp. 421-426
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing

    Jansen, I. E., Ye, H., Heetveld, S., Lechler, M. C., Michels, H., Seinstra, R. I., Lubbe, S. J., Drouet, V., Lesage, S., Majounie, E., Gibbs, J. R., Nalls, M. A., Ryten, M., Botia, J. A., Vandrovcova, J., Simon-Sanchez, J., Castillo-Lizardo, M., Rizzu, P., Blauwendraat, C., Chouhan, A. K., Li, Y., Yogi, P., Amin, N., van Duijn, C. M., International Parkinson's Disease Genetics Consortium (IPGDC), Morris, H. R., Brice, A., Singleton, A. B., David, D. C., Nollen, E. A., Jain, S., Shulman, J. M., Heutink, P., Hernandez, D. G., Arepalli, S., Brooks, J., Price, R., Nicolas, A., Chong, S., Cookson, M. R., Dillman, A., Moore, M., Traynor, B. J., Singleton, A. B., Plagnol, V., Nicholas W Wood, W. W., Sheerin, U. M., Jose M Bras, M. B., Charlesworth, G., Gardner, M., Counsell, C.
    Genome Biology, vol. 18, no. 1, 22
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Medium-term prognosis of an incident cohort of parkinsonian patients compared to controls

    Fielding, S., MacLeod, A. D., Counsell, C. E.
    Parkinsonism & Related Disorders, vol. 32, pp. 36-41
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Predictors of functional dependency in Parkinson’s disease

    MacLeod, A. D., Counsell, C. E.
    Movement Disorders, pp. 1482-1488
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Stroke: Are care and outcomes better for participants of stroke trials?

    Macleod, M. J., Counsell, C. E.
    Nature Reviews Neurology, vol. 12, no. 9, pp. 498-499
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Risk of fracture amongst patients with Parkinson's disease and other forms of parkinsonism

    Sleeman, I., Che, Z. C., Counsell, C.
    Parkinsonism & Related Disorders, vol. 29, pp. 60-65
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Co-morbidity burden in Parkinson’s disease: Comparison with controls and its influence on prognosis

    MacLeod, A. D., Goddard, H., Counsell, C. E.
    Parkinsonism & Related Disorders, vol. 28, pp. 124-129
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer's disease and Parkinson's disease

    McGhee, D. J. M., Ritchie, C. W., Zajicek, J. P., Counsell, C. E.
    BMC Neurology, vol. 16, pp. 1-13
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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