51cg

People

Dr Dawn Thompson

Dr Dawn Thompson
Dr Dawn Thompson
Dr Dawn Thompson

BSc, PhD

Lecturer

51cg
Email Address
dthompson@abdn.ac.uk
Office Address

office 6.15/lab 2.48

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences,

Foresterhill, Aberdeen

ext: office:7513

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I received my B.Sc Hons in Pharmacology from the 51cg before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity.  I returned to the 51cg and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.     

Research

Research Overview

My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.  

Research Areas

Biomedical Sciences

View Research Area

Research Specialisms

  • Pharmacology
  • Neuroscience
  • Cell Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Publications

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  • Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. M., Delibegovic, M.
    Molecular Metabolism, vol. 6, no. 8, pp. 845-853
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Novel G protein-coupled receptors in Pancreatic Beta cells

    Saunders, F., Iyinikkel, J., Lima, M., Thompson, D., Delibegovic, M., Docherty, K., Murray, F.
    Experimental Biology, 1052.1
    Contributions to Journals: Abstracts
    • [ONLINE]

  • Identification of a novel recycling sequence in the C-tail of FPR2/ALX: association with cell protection from apoptosis

    Thompson, D., McArthur, S., Hislop, J. N., Flower, R. J., Perretti, M.
    The Journal of Biological Chemistry, vol. 289, pp. 36166-36178
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

    Cooray, S. N., Gobbetti, T., Montero-Melendez, T., McArthur, S., Thompson, D., Clark, A. J. L., Flower, R. J., Perretti, M.
    PNAS, vol. 110, no. 45, pp. 18232-18237
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Increased axonal bouton dynamics in the aging mouse cortex

    Grillo, F. W., Song, S., Teles-Grilo Ruivo, L. M., Huang, L., Gao, G., Knott, G. W., Maco, B., Ferretti, V., Thompson, D., Little, G. E., De Paola, V.
    PNAS, vol. 110, no. 16, pp. E1514-E1523
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Trafficking properties of the D5 dopamine receptor

    Thompson, D., Whistler, J. L.
    Traffic, vol. 12, no. 5, pp. 644-56
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions

    Tschammer, N., Elsner, J., Goetz, A., Ehrlich, K., Schuster, S., Ruberg, M., Kühhorn, J., Thompson, D., Whistler, J., Hübner, H., Gmeiner, P.
    Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2477-91
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1

    Thompson, D., Whistler, J. L.
    The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1598-608
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine

    Thompson, D., Martini, L., Whistler, J. L.
    PloS ONE, vol. 5, no. 6, pp. e11038
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1

    Martini, L., Thompson, D., Kharazia, V., Whistler, J. L.
    Neuropsychopharmacology, vol. 35, no. 6, pp. 1363-73
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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