51cg

People

Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

51cg
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the 51cg, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - 51cg 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available  on using instrumental variables in a surgery trial to address non-compliance. Collaborators were  (Oxford), (Lancaster), and (Manchester). 

Research on making trials more efficient, collaborating with . 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • TACTICAL1 Trial protocol: Targeted Abdominal CT in Conjunction with Lung Cancer Screening to identify kidney cancer and other abdominal conditions – A Randomised Controlled Pilot Study

    Rossi, S., Kitt, J., Clark, M., Bradley, R., Byass, O., Cotton, S., Holmes, T., Kyriazis, G., MacLennan, G., Manning, S., Massey, K., Modi, R., Myatt, A., Pawluk, J., Rodrigues, J. C. L., Tariq, K., Stephens, A., Wood, T., Usher-Smith, J. A., Stewart, G. D.
    European Urology Oncology
    Contributions to Journals: Articles

  • 24 months outcomes from the non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery

    Constable, L., Drake, M. J., Cooper, D., MacLennan, G., Harding, C., Mundy, A., McCormack, K., Norrie, J., Ramsay, C., Smith, R., Cotterill, N., Kilonzo, M., Abrams, P., MASTER trial team
    European Urology Focus
    Contributions to Journals: Articles

  • Effectiveness and cost-effectiveness of text message and financial incentives for weight management in men with obesity: The Game of Stones RCT

    Macaulay, L., O'Dolan, C., Dombrowski, S., Swingler, J., Cotton, S., Avenell, A., Boyers, D., Getaneh, A. M., Gray, C., Hunt, K., Kee, F., MacLean, A., McKinley, M., Torrens, C., Turner, K., van der Pol, M., MacLennan, G., Hoddinott, P.
    Public Health Research, vol. 14, no. 10
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • PARTIAL: study protocol for a clinical and cost-effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma randomised trial

    Johnson, D., Thomas, R., Cotton, S., Newlands, R., Cooper, D., McCann, S., Vale, L., Gillies, K., Bex, A., Challacombe, B., Falloon, J., MacLennan, G., Narahari, K., Nicol, D., Sheerin, N., Stewart, G. D., Tran, M., Heer, R., Soomro, N.
    Trials, vol. 27, no. 1, 331
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Comparing the clinical and cost-effectiveness of various washout policies in preventing catheter associated complications in adults living with long-term catheters: synopsis of the CATHETER II RCT

    Johnson, D., Tripathee, S., Cooper, D., Constable, L., Omar, M. I., MacLennan, S., Cotton, S., Dimitropoulos, K., Evans, S., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, G., Murchie, P., Kyaw Myint, P., N'Dow, J., Norrie, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A., Abdel-fattah, M.
    Health Technology Assessment, vol. 30, no. 26
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Ten Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement

    Beard, D. J., Davies, L. J., Cook, J. A., MacLennan, G., Hudson, J., Price, A. J., Carr, A. J., Little, M., Leal, J., Fitzpatrick, R., Murray, D. W., Campbell, M., TOPKAT Study Group
    The Lancet Rheumatology, vol. 8, no. 2, pp. e116-e126
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data

    Morrison, A. P., Pyle, M., Law, H., Emsley, R., MacLennan, G., Hudson, J.
    Schizophrenia Bulletin, vol. 52, no. 1, sbaf121
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A feasibility study of a co-designed intervention to manage benzodiazepine dependence and high-risk use in those receiving opioid agonist treatment

    Matheson, C., Berry, K., Kilonzo, M., Galea-Singer, S., Hill, D., Ritchie, T., Schofield, J., Stewart, D., Turner, M., MacLennan, G.
    Pilot and Feasibility Studies, vol. 12, no. 1, 4
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial

    Parkes, T., Carver, H., Boyd, J., Cotton, S., Breeman, S., Cooper, D., Forrest, M., Foster, R., Hawthorn, J., Hunt, K., Kilonzo, M., Matheson, C., Maxwell, M., Mercer, S. W., Pauly, B., Scotland, G., Steele, W., Sumnall, H., Wallace, J., Macaulay, L., MacLennan, G.
    Trials, vol. 27, 18
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical and cost-effectiveness of medical management versus surgery for deep infiltrating endometriosis: synopsis from the DIAMOND RCT

    Cooper, K., Constable, L., Vadiveloo, T., Matuluko, A., Kennedy, C., McCann, S., Cotton, S., Gillies, K., Bruce, R., Smith, P., MacLennan, G., Clark, T. J.
    Health Technology Assessment, vol. 30, no. 62, pp. 437-464
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Reply to Zhihao Lei’s Letter to the Editor re: Oliver Wiseman, Daron Smith, Kathryn Starr, et al. The PUrE Randomised Controlled Trial 1: Clinical and Cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for Lower Pole Stones ≤10 mm. Eur Urol 2025;88:179–89

    Wiseman, O., Smith, D., Starr, K., Aucott, L., Hernández, R., Thomas, R., MacLennan, S., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology, vol. 89, no. 1, pp. e23-e24
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [ONLINE]

  • Patient engagement and shared decision-making in trial recruitment intervention studies: a systematic review

    Morgan, T. L., Hudek, N., Carroll, K., Yee, M., Inglis, J., Fergusson, D. A., Gillies, K., Richards, D. P., Semchishen, S. N., Presseau, J., Grimshaw, J., Graham, I. D., Rodger, M., Taljaard, M., Marlin, S., Weijer, C., MacLennan, G., Brehaut, J. C.
    Research Involvement and Engagement, vol. 11, no. 1, 142
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • CATHETER II, a Randomised Controlled Trial Comparing the Clinical and Cost Effectiveness of Various Washout Policies versus No Washout Policy in Preventing Catheter Associated Complications in Adults Living with Long Term Catheters

    Abdel-Fattah, M., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Omar, M. I., Catheter II Team
    45th Congress of the Société Internationale d'Urologie, pp. 238-239
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • ColoCap: determining the diagnostic accuracy of colon capsule endoscopy compared with standard colonoscopy in patients at risk of colorectal disease: a study protocol

    Ibrahim, H., Haritakis, M., Ballantine, L., McCormack, K., Cotton, S., Hudson, J., Atkin, K., Rogers, S., Nixon, L. S., Verghese, A., Holmes, H., Treweek, S., MacLennan, G., Dolwani, S., Gardner, G., Hurt, C., Watson, A. J. M., Turvill, J. L.
    BMJ Open, vol. 15, no. 9, e104661
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Spirometry to manage asthma in children: a study protocol for a randomised controlled trial (SPIROMAC)

    Bell, V., Sergenson, N., Cotton, S., Emele, C. D., Thomas, R., Aucott, L., Forrest, M., Gaillard, E. A., Kennington, E., MacLennan, G., Sinha, I., Vadiveloo, T., Scott, N., Turner, S.
    Trials, vol. 26, 373
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • PUrE Randomised Controlled Trial 2: Clinical and Cost Effectiveness of Flexible Ureterorenoscopy and Percutaneous Nephrolithotomy for Lower-pole Stones of 10–25 mm

    Smith, D., Wiseman, O., Starr, K., Aucott, L., Hernández, R., Thomas, R., MacLennan, S., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology Focus, vol. 11, no. 5, pp. 684-694
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Updated Systematic Review and Meta-analysis of Extracorporeal Shock Wave Lithotripsy, Flexible Ureterorenoscopy, and Percutaneous Nephrolithotomy for Lower Pole Renal Stones

    MacLennan, S., Wiseman, O. J., Smith, D., Starr, K., Aucott, L., Hernández, R. A., Manson, P., Thomas, R., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology, vol. 88, no. 3, pp. 231-239
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs

    Wiseman, O., Smith, D., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, C. T., Maclennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    Health Technology Assessment, vol. 29, no. 40
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Secondary analysis of the Game of Stones trial for men with obesity: Examining moderator effects and exploratory outcomes

    Dombrowski, S. U., Hoddinott, P., Macaulay, L., O’Dolan, C., Swingler, J., Cotton, S., Avenell, A., Getaneh, A., Gray, C., Hunt, K., Kee, F., MacLean, A., McKinley, M. C., Torrens, C., Turner, K., Van der Pol, M., MacLennan, G.
    Obesity, vol. 33, no. 8, pp. 1432-1446
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • The PUrE Randomised Controlled Trial (RCT) 1: Clinical and cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for lower pole stones ≤10mm.

    Wiseman, O. J., Smith, D., Starr, K., Aucott, L., Hernández, R. A., Thomas, R., MacLennan, S., Clark, C. T., MacLennan, G., McRae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., McClinton, S.
    European Urology, vol. 88, no. 2, pp. 179-189
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation

    Abdel-Fattah, M., Chapple, C., Breeman, S., Cooper, D., Bell-Gorrod, H., Kuppanda, P., Guerrero, K. L., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M., Gammie, A., Mostafa, A., Bruce, R., Bell, V., Kennedy, C., Evans, S., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 29, no. 27
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women

    Bell-Gorrod, H., Thokala, P., Breeman, S., Cooper, D., MacLennan, G., Abdel-Fattah, M., Dixon, S.
    BJU International, vol. 136, no. 1, pp. 82-94
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Text messaging with or without financial incentives versus a waitlist control for weight loss in men: cost-effectiveness analysis of the Game of Stones randomised controlled trial

    Getaneh, A., van der Pol, M., Boyers, D., Avenell, A., Cotton, S., Dombrowski, S. U., Gray, C., Kee, F., Macaulay, L., McKinley, M. C., O'Dolan, C., Swingler, J., Torrens, C., Turner, K., MacLennan, G., Hoddinott, P.
    The Lancet Regional Health - Europe, vol. 54, 101328
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT

    Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J., Wilson, A., Wu, O., Lipworth, B.
    Health Technology Assessment, vol. 29, no. 17, pp. i-xvi, 1-97
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Patients and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Abdel-Fattah, M., Johnson, D., Constable, L., Cotton, S., Cooper, D., MacLennan, G., Evans, S., Young, A. J., Dimitropoulos, K., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Norrie, J., Omar, M. I., MacLennan, S.
    BMJ Open, vol. 15, no. 4, e087206
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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