Director (CHaRT)
- 51cg
-
- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition

Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the 51cg, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - 51cg
- MSc Applied Statistics2004 - Sheffield Hallam University
- Research
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Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available on using instrumental variables in a surgery trial to address non-compliance. Collaborators were (Oxford), (Lancaster), and (Manchester).
Research on making trials more efficient, collaborating with .
Current Research
A complete list of the CHaRT RCT portolio is available by clicking
- Teaching
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Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
- Publications
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TACTICAL1 Trial protocol: Targeted Abdominal CT in Conjunction with Lung Cancer Screening to identify kidney cancer and other abdominal conditions – A Randomised Controlled Pilot Study
European Urology OncologyContributions to Journals: Articles24 months outcomes from the non-inferiority randomised controlled trial of surgery for men with urodynamic stress incontinence after prostate surgery
European Urology FocusContributions to Journals: ArticlesEffectiveness and cost-effectiveness of text message and financial incentives for weight management in men with obesity: The Game of Stones RCT
Public Health Research, vol. 14, no. 10Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
PARTIAL: study protocol for a clinical and cost-effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma randomised trial
Trials, vol. 27, no. 1, 331Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Comparing the clinical and cost-effectiveness of various washout policies in preventing catheter associated complications in adults living with long-term catheters: synopsis of the CATHETER II RCT
Health Technology Assessment, vol. 30, no. 26Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Ten Year Follow-Up of a Multicentre Randomised Controlled Trial Assessing Clinical and Cost Effectiveness of Total Versus Partial Knee Replacement
The Lancet Rheumatology, vol. 8, no. 2, pp. e116-e126Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Relative Effectiveness of Cognitive Behavior Therapy, Antipsychotics and the Combination for People with First Episode Psychosis: A Two-Study Pooled Analysis of Individual Participant Data
Schizophrenia Bulletin, vol. 52, no. 1, sbaf121Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A feasibility study of a co-designed intervention to manage benzodiazepine dependence and high-risk use in those receiving opioid agonist treatment
Pilot and Feasibility Studies, vol. 12, no. 1, 4Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial
Trials, vol. 27, 18Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Clinical and cost-effectiveness of medical management versus surgery for deep infiltrating endometriosis: synopsis from the DIAMOND RCT
Health Technology Assessment, vol. 30, no. 62, pp. 437-464Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Reply to Zhihao Lei’s Letter to the Editor re: Oliver Wiseman, Daron Smith, Kathryn Starr, et al. The PUrE Randomised Controlled Trial 1: Clinical and Cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for Lower Pole Stones ≤10 mm. Eur Urol 2025;88:179–89
European Urology, vol. 89, no. 1, pp. e23-e24Contributions to Journals: Letters- [ONLINE] DOI:
- [ONLINE]
Patient engagement and shared decision-making in trial recruitment intervention studies: a systematic review
Research Involvement and Engagement, vol. 11, no. 1, 142Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
CATHETER II, a Randomised Controlled Trial Comparing the Clinical and Cost Effectiveness of Various Washout Policies versus No Washout Policy in Preventing Catheter Associated Complications in Adults Living with Long Term Catheters
45th Congress of the Société Internationale d'Urologie, pp. 238-239Contributions to Journals: Abstracts- [ONLINE] DOI:
ColoCap: determining the diagnostic accuracy of colon capsule endoscopy compared with standard colonoscopy in patients at risk of colorectal disease: a study protocol
BMJ Open, vol. 15, no. 9, e104661Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Spirometry to manage asthma in children: a study protocol for a randomised controlled trial (SPIROMAC)
Trials, vol. 26, 373Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
PUrE Randomised Controlled Trial 2: Clinical and Cost Effectiveness of Flexible Ureterorenoscopy and Percutaneous Nephrolithotomy for Lower-pole Stones of 10–25 mm
European Urology Focus, vol. 11, no. 5, pp. 684-694Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Updated Systematic Review and Meta-analysis of Extracorporeal Shock Wave Lithotripsy, Flexible Ureterorenoscopy, and Percutaneous Nephrolithotomy for Lower Pole Renal Stones
European Urology, vol. 88, no. 3, pp. 231-239Contributions to Journals: Review articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
- [ONLINE]
Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs
Health Technology Assessment, vol. 29, no. 40Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Secondary analysis of the Game of Stones trial for men with obesity: Examining moderator effects and exploratory outcomes
Obesity, vol. 33, no. 8, pp. 1432-1446Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [OPEN ACCESS]
The PUrE Randomised Controlled Trial (RCT) 1: Clinical and cost-effectiveness of Flexible Ureterorenoscopy and Extracorporeal Shockwave Lithotripsy for lower pole stones ≤10mm.
European Urology, vol. 88, no. 2, pp. 179-189Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation
Health Technology Assessment, vol. 29, no. 27Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Long-term cost-effectiveness of invasive urodynamic studies for overactive bladder in women
BJU International, vol. 136, no. 1, pp. 82-94Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Text messaging with or without financial incentives versus a waitlist control for weight loss in men: cost-effectiveness analysis of the Game of Stones randomised controlled trial
The Lancet Regional Health - Europe, vol. 54, 101328Contributions to Journals: Articles- [ONLINE] DOI:
Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT
Health Technology Assessment, vol. 29, no. 17, pp. i-xvi, 1-97Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Patients and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
BMJ Open, vol. 15, no. 4, e087206Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms (FUTURE) in the UK: a multicentre, superiority, parallel, open-label, randomised controlled trial
The Lancet, vol. 405, no. 10484, pp. 1057-1068Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
European Association of Urology Annual Congress 2025, pp. A0090Contributions to Conferences: Abstracts- [ONLINE]
Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery: A Health Economic Evaluation of the ALLEGRO Randomised Clinical Trial
BMJ Open, vol. 15, no. 2, e088298Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
ICANEQUAL multi-stakeholder partnership: Reducing inequalities in liver cancer (HCC) diagnosis, treatment and care across the UK
NIHR Open Research, vol. 5, no. 5Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Intravenous lidocaine for gut function recovery in colonic surgery: A Randomized Clinical Trial
JAMA, vol. 333, no. 1, pp. 39-48Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Complexity of Trials on Pain Management in Acute Pancreatitis: An Ongoing Challenge
Clinical Gastroenterology and Hepatology, vol. 23, no. 1Contributions to Journals: Letters- [ONLINE] DOI:
- [ONLINE]
Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial
British Journal of Surgery, vol. 112, no. 1, znae293Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
A feasibility randomized controlled trial of an individually delivered, peer support intervention to reduce the impact of psychosis stigma and discrimination for people with psychosis: the let's talk study
Psychological Medicine, vol. 54, no. 16, pp. 4600-4611Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
CATHETER II: a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
BMJ Open, vol. 14, no. 12, e087203Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT
Public Health Research, vol. 12, no. 17Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Which glaucoma patients should be monitored at home and exploration of clinician perceptions on home monitoring? a survey of glaucoma specialists in the UK
BMJ Open, vol. 14, no. 11, pp. e080873Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
The International Continence SocietyContributions to Conferences: Posters- [ONLINE]
- [ONLINE]
RCT comparing the clinical and cost effectiveness of various catheter washout policies
RCOG World Congress 2024, MTeP-42Contributions to Journals: Abstracts- [ONLINE]
- [ONLINE] DOI:
CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters
The International Continence Society, 101602Contributions to Journals: Abstracts- [ONLINE] DOI:
Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial
RCOG World Congress 2024, pp. 171Contributions to Journals: Abstracts- [ONLINE] DOI:
- [ONLINE]
The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT
Health Technology Assessment, vol. 28, no. 54Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Public perspective on potential treatment intervention harm in clinical trials-terminology and communication
Trials, vol. 25, no. 1, 573Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Feasibility of in-home monitoring for people with glaucoma: the I-TRAC mixed-methods study
Health technology assessment (Winchester, England), vol. 28, no. 44, pp. 1-163Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial
JAMA, vol. 332, no. 1, pp. 31-40Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
- [ONLINE]
Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Ophthalmology, vol. 131, no. 7, pp. 759-770Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Assessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units
BJA Open, vol. 10, 100287Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT
Health Technology Assessment, vol. 28, no. 26, pp. 1-151Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial
JAMA, vol. 332, no. 6, pp. 462-470Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
- [ONLINE]
Prevalencia del cáncer del tracto urinario. Análisis de la cohorte española del estudio IDENTIFY
Actas Urologicas Espanolas, vol. 48, no. 3, pp. 228-237Contributions to Journals: Articles- [ONLINE] DOI:
- [ONLINE]
Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply
JAMA, vol. 331, no. 11, pp. 981-982Contributions to Journals: Comments and Debates- [ONLINE] DOI: