51cg

People

Dr Ian Fleming

Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

51cg
Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition


Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

Page 1 of 6 Results 1 to 10 of 53

  • Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer

    Alwadani, B., Dall'Angelo, S., Fleming, I.
    Insights into Imaging, vol. 12, no. 1, 90
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Synthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR

    Musolino, M., Fleming, I. N., Schweiger, L. F., O'hagan, D., Dall'Angelo, S., Zanda, M.
    European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

    Hernandez Gerez, E., Dall'angelo, S., Collinson, J. M., Fleming, I. N., Parson, S. H.
    Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Hypoxia PET/CT and Colorectal Cancer: A Case Report

    Laws, K., Murray, G. I., Kerr, K., McKiddie, F., Dall'angelo, S., Zanda, M., Fleming, I., Samuel, L.
    Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A role for spinal cord hypoxia in neurodegeneration

    Hernandez Gerez, E., Fleming, I. N., Parson, S. H.
    Cell Death & Disease, vol. 10, 861
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

    Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M., O'Hagan, D.
    Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the 51cg

    Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A., Wallace, H. M.
    Contributions to Specialist Publications: Featured Articles
    • [ONLINE]

  • Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

    Andriu, A., Crockett, J., Dall'Angelo, S., Piras, M., Zanda, M., Fleming, I. N.
    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

    Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J., Zanda, M.
    ChemMedChem, vol. 12, no. 14, pp. 1142-1151
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

    Lazzari, P., Spiga, M., Sani, M., Zanda, M., Fleming, I. N.
    Hypoxia, vol. 5, pp. 45-59
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
Show 10 | 25 | 50 | 100 results per page

Refine

Contributions to Journals

Contributions to Specialist Publications

Update