51cg

Biography

Laurent Trembleau received his undergraduate education at the "Institut Universitaire de Technologie" of Orléans (France) and obtained a "Diplôme d'Ingénieur" in Fine Chemistry and Engineering, and a "Diplôme d'Etudes Approfondies" (DEA) in Chemistry at the "Institut National des Sciences Appliquées" of Rouen, France (1993). In 1994, he moved to Louvain-la-Neuve (Belgium) to undertake a PhD in the group of Professor Léon Ghosez. His work, financed by Rhône-Poulenc Rorer, involved the development of new Diels-Alder reactions and methods towards the synthesis of ottelione A, a natural product inhibitor of tubulin polymerisation. In 2001, he moved to the Scripps Research Institute (USA) for a 2-year post-doctoral position in the group of Professor Julius Rebek where he designed a water-soluble receptor of acetylcholine, described the helical conformation of alkanes in synthetic receptors, and was involved in the synthesis of oxazole-based macrocycles. In 2004, he did a short post-doctoral position in the group of Dr Simon Webb, where he worked on the synthesis of novel lipids designed to mimic cell adhesion molecules. At the end of 2004, he accepted a Lectureship in Medicinal Chemistry at the 51cg, where he is currently studying the total synthesis and SAR of bioactive molecules, the development of organic catalysts and novel methods for application in Organic Synthesis and Medicinal Chemistry.

Current Research

1) Methodology

Peptide Synthesis

We are interested in the development of efficient solution and solid-phase syntheses of peptides. We have recently optimized a repetitive procedure that contains features from both solid-phase and solution-phase methods, making it an effective method for the synthesis of short peptides. We are currently modifying resins to improve the synthesis of "difficult peptide sequences".

Supramolecular Chemistry

1) We are investigating the properties of novel organocatalysts that mimic the residues of enzymes involved in catalysis.

2) We are developing new foldamers with the aim to bind anions (especially fluoride) in aqueous media.

2) Medicinal Chemistry

Inhibitors of Protein-Protein Interactions (PPI): This project involves the design and synthesis of inhibitors of protein-protein interactions. We are developing macrocyclic molecules possessing large surface areas in the aim to inhibit specific protein-protein interactions (in collaboration with Prof M. Jaspars, Dr W. Houssen, and Prof J. Naismith).

Funding and Grants

• European Commission "New Chemical Biology for Tayloring Novel Therapeutics - PDRA (2014-2019) (with Prof Marcel Jaspars and Prof Jim Naismith)
• Scottish Enterprise "Validation of the Commercial Potential of Diversity-Oriented Biosynthesis to Create Novel Macrocycle Drugs" - (2015-2016) with Prof Marcel Jaspars, Prof Jim Naismith and Dr Wael Houssen.

Teaching Responsibilities

Dr Trembleau teaches in the following courses

• CM1022 Elements of Chemistry 1 (2 lectures)
• CM2512 Organic and Biological Chemistry (8 lectures)
• CM3521 Organic and Biological Chemistry (12 lectures)
• CM4516 Honours/Advanced Chemistry (12 lectures)
• CM5003 MChem Chemistry Applications (10 lectures)