BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- 51cg
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
51cg
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
2001 PhD, Thrombosis & Vascular Biology; 51cg
1997 BSc (Hons) Molecular Biology; 51cg
Employment
2022- Cardiometabolic Disease Theme Lead, 51cg
2021- Personal Chair, 51cg
2017-2021 Reader, 51cg
2016- 2017 Senior Lecturer, 51cg
2011– 2016 British Heart Foundation Fellow, Senior Research Fellow, 51cg
2010-2011 British Heart Foundation Fellow, Lecturer, 51cg
2007-2010 Independent Research Fellow in cardiovascular medicine, University of Leeds, UK
2004-2006 Postdoctoral research associate, University of Illinois at Urbana-Champaign, USA
Qualifications
- BSc hons Molecular Biology1997 - 51cg
- PhD Thrombosis & Vascular Biology2001 - 51cg
External Memberships
2024-2030: Council Member of the International Society for Thrombosis and Haemostasis (ISTH)
2024-2026: Vice-Chair of the Education Committee of the ISTH
2024-2028: European Haematology Association (EHA) Fellowships & Grants Committee
2021-2024: Past President of the British Society of Haemostasis and Thrombosis (BSHT)
2022-2024: Basic Science Chair of the Annual Congress Planning Committee of the ISTH
2023 onwards: Steering Committee of UK Thrombosis Research Network
2024: Faculty Member of the CAS-AM course on anticoagulation management
Latest Publications
ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP
Journal of Thrombosis and HaemostasisContributions to Journals: Articles- [ONLINE] DOI:
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
Molecular MedicineContributions to Journals: Articles- [ONLINE] DOI:
Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay
Blood Advances, vol. 10, no. 7, pp. 2173-2181Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
European Journal of Pharmacology, vol. 1020, 178725Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Prizes and Awards
2024: ISTH Esteemed Career Award
2012: Desiree Collen Young Investigator Award, International Society of Fibrinolysis & Proteolysis
- Research
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Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Supervision
My current supervision areas are: Biomedical Sciences.
Current PhD Students
Kieran Pocknell Co-Supervisors Dr Claire Whyte, Dr Dana Huskens (The Synapse Research Institute, The Netherlands)
- Funded by Medical Research Scotland
Jack Partridge, Co-Supervisors Dr Claire Whyte, Dr Mairead Black
- Funded by John Shivas Trust
Tarek Al Tarawni, Co-Supervisors Dr Claire Whyte, Prof Mary Joan Macleod
- Funded by Aqaba Medical Sciences University
Sara Sharaf, Principal supervisor Prof Karolin Hijazi, Co-Supervisors Prof Dana Dawson, Prof Nicola J Mutch
- Funded by Elphinstone Scholarship
Graduated PhD Students
Dr Joanne Mitchell, Funded by 51cg Development Trust and Friends of Anchor. Graduated 2016
Dr Mohammad Jalal: Funded by the Saudi Arabian Government. Graduated 2017
Dr Gael Morrow: Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood, Graduated, 2018
Dr Paraskevi Untiveros: Funded by the Chief Scientist Office. Clinical Fellow, Graduated 2018
Dr Maria-Louise Williams: Funded by the Institute of Medical Sciences, 51cg. Graduated, 2023
Dr Um-May Sumya, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2023
Dr Fahad Alshehri, Funded by Royal Embassy of Saudi Arabia Cultural Bureau, Graduated
Dr Steven Humphrey, Funded by BHF-NC3R's, Graduated 2025
Dr Anuj Narwal, Funded by Elphinstone Scholarship, Univeristy of Aberdeen, Graduated, 2026
Dr Madeline Rhodes, Funded by Marie-Curie Fellowship, Graduated, 2026
Funding and Grants
2026 Medical Research Scotland. Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. £147,385.31. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Dr Dana Huskens.
2026 Chief Scientist Office. Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. PI Prof NJ Mutch, Co-I, Dr Lucy de Lyold, Dr Sarah Bell, Dr Mairead Black Dr Claire Whyte, Prof Peter Collins.
2025 Heart Research UK. Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. £225,000. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog.
2025 BHF. Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. £309,764.10., PI: Dr Claire Whyte, Co-I Prof NJ Mutch, Co-I Prof Valerie Speirs
2024 BHF. S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. £289,206. PI Prof NJ Mutch, Co-I Dr Julie Rayes, Dr Claire Whyte and Dr Alexander Brill.
2024 Friends of Anchor. Development of an endothelialised model of deep vein thrombosis. PI Prof NJ Mutch, Co-I Dr Claire Whyte Mr Steven Humphreys. £15,000.
2023 Heart Research UK. Aetiology of impaired fibrinolysis in acute coronary syndrome and appropriate treatment strategies. PI Prof NJ Mutch, Co-I Dr Claire Whyte, Prof Diana Gorog. £199,970.
2022 Medical Research Scotland PhD Studentship. The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. £122,011. PI, Prof NJ Mutch Co-I Dr Claire Whyte.
2022 NC3Rs-BHF PhD studentship. Modelling of thrombus dynamics in a microfluidic ‘vasculature’. PI, Prof NJ Mutch, Co-I Dr Claire Whyte. £90,000
- Teaching
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Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
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Page 3 of 4 Results 51 to 75 of 89
Polyphosphate co-localizes with factor XII on plateletbound fibrin and augments its plasminogen activator activity
Blood, vol. 128, no. 24, pp. 2834-2845Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network
Thrombosis and Haemostasis, vol. 116, no. 5, pp. 897-903Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy
Blood, vol. 128, no. 14, pp. 1879-1883Contributions to Journals: Articles- [ONLINE]
- [ONLINE] DOI:
- [OPEN ACCESS]
Novel aspects of platelet factor XIII function
Thrombosis Research, vol. 141, no. Suppl 2, pp. S17-21Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
polyphosphate co-localises with FXII on platelet-bound fibrin and markedly augments alpha FXIIa-mediated plasminogen activation
Journal of Thrombosis and Haemostasis, vol. 14, no. Suppl.1, pp. 39Contributions to Journals: Abstracts- [ONLINE] DOI:
Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI:
- [ONLINE]
Polyphosphate as a haemostatic modulator
Biochemical Society Transactions, vol. 44, no. 1, pp. 18-24Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Harmonisation of D-dimer - A call for action
Thrombosis Research, vol. 137, pp. 219-220Contributions to Journals: Articles- [ONLINE] DOI:
Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 13, no. 12, pp. 2277-2278Contributions to Journals: Articles- [ONLINE] DOI:
- [ONLINE]
Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)
Thrombosis Research, vol. 136 , no. Suppl 1, pp. S3-S7Contributions to Journals: Articles- [ONLINE] DOI:
Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Blood, vol. 125, no. 16, pp. 2568 - 2578Contributions to Journals: Articles- [ONLINE] DOI:
Functional factor XIII-A is exposed on the stimulated platelet surface
Blood, vol. 124, no. 26, pp. 3982–3990Contributions to Journals: Articles- [ONLINE] DOI:
Single-chain factor XII exhibits activity when complexed to polyphosphate
Journal of Thrombosis and Haemostasis, vol. 12, no. 9, pp. 1513-1522Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Biochemical Society Transactions, vol. 42, no. 4, pp. 928-933Contributions to Journals: Articles- [ONLINE] DOI:
Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation
Blood, vol. 122, no. 23, pp. 3847-3849Contributions to Journals: Letters- [ONLINE] DOI:
Thrombin-anti-thrombin levels and patency of arterio-venous fistula in patients undergoing haemodialysis compared to healthy volunteers: a prospective analysis
PloS ONE, vol. 8, no. 7, e67799Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Insights into thrombin activatable fibrinolysis inhibitor function and regulation
Journal of Thrombosis and Haemostasis, vol. 11, no. Suppl 1, pp. 306-315Contributions to Journals: Articles- [ONLINE] DOI:
Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi
Journal of Thrombosis and Haemostasis, vol. 11, no. 1, pp. 190-192Contributions to Journals: Articles- [ONLINE] DOI:
The Role of Platelets in Fibrinolysis
Platelets. Michelson, A. (ed.). 3 edition. Elsevier Inc, pp. 469-485, 17 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI:
- [ONLINE]
Immobilized transition metal ions stimulate contact activation and drive factor XII-mediated coagulation
Journal of Thrombosis and Haemostasis, vol. 10, no. 10, pp. 2108-2115Contributions to Journals: Articles- [ONLINE] DOI:
"A Growing Body of Evidence Demonstrates Crosstalk Within the Haemostatic System, and It Appears That These Interconnecting Pathways Allow Fine Tuning and Balance of the Different Systems in Our Body"
Circulation, vol. 125, no. 23, pp. F133-F134Contributions to Journals: Editorials- [ONLINE] DOI:
Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI:
Platelet factor XIII stabilises thrombi against premature fibrin degradation
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E15Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI:
Polyphosphate scores a hat trick in regulating host defense mechanisms
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. 1142-1144Contributions to Journals: Editorials- [ONLINE] DOI:
Polyphosphate stabilises factor XIIa and acts as a cofactor in factor XIIa-mediated plasminogen activation
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E13Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI: