51cg

Professor Roy Soiza

Professor Roy Soiza
Professor Roy Soiza
Professor Roy Soiza

MB ChB MRCP(UK)

Honorary Chair

51cg
Email Address
r.l.soiza@abdn.ac.uk
Office Address

c/o Ageing Clinical & Experimental Research, 51cg, Room 1:128, Polwarth Building, Aberdeen AB25 2ZD United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition


Biography

I am a Consultant Geriatrician in NHS Grampian and Honorary Chair within the Ageing Clinical and Experimental Research (ACER) Group within the 51cg. I am the Editor-in-Chief of Age & Ageing, one of the world's leading geriatric medicine journals.

I graduated from Edinburgh University in 2000 and became a Member of the Royal College of Physicians in 2003. Later that year, I joined the North of Scotland training programme as a Specialist Registrar in Geriatric Medicine and General Internal Medicine. In 2006, I joined the 51cg as Clinical Lecturer in Elderly Medicine.

I have been a Consultant Geriatrician with NHS Grampian since 2008, except 2018-2023 when I worked within General Medicine at Aberdeen Royal Infirmary. I have held numerous roles in postgraduate medical training, including Training Programme Director for Core Medical Training and Geriatric Medicine and serving as Associate Postgraduate Dean from 2015-2017.  

I was awarded an NRS Career Researcher Fellowship in 2012. I was promoted to Honorary Chair in February 2024, having previously held the roles of Honorary Clinical Senior Lecturer and Honorary Reader. 

External Memberships

  • Consultant Physician, NHS Grampian
  • Editor in Chief, Age & Ageing 2024- (previously Senior Editor 2022-4, Associate Editor 2020-2)
  • Reviewer, for numerous international medical journals and grant-awarding bodies including MRC, CSO, NIHR, Research Council of Norway, South African Medical Research Council and Italian Ministry of Education, Universities & Research
  • External Examiner, MSc (Hons) and PhD at various universities internationally

 

Previous Roles

 

  • Associate EditorTherapeutic Advances in Drug Safety 2010-2025, Geriatric Pharmacology 2023-2025 
  • Chair, Data Monitoring Committee, CONFORM-OH trial
  • Associate Postgraduate Dean (Medicine), NES, 1st Feb 2015 – 31st Aug 2017

  • NRS Career Research Fellow 2012-5

  • HIS Growing Older in Scotland Report, Reference Group Member
  • Treasurer, Scottish Society of Physicians, 2014-8

  • Executive Committee Member, Scottish Society of Physicians, 2012-8

  • Scottish Intercollegiate Guideline Network (SIGN), Delirium Guideline Development Group Member 2016-9, Dementia Guideline Group Member 2020-

  • Chair, Organising Committee, RCPE Geriatric Medicine Symposium 2019

  • Faculty Member, Faculty Development Alliance (formerly SCOTS Supervisor Training Courses), 2010-7

  • Electives Adviser, 51cg Medical School, 2010-8

  • Training Programme Director, North of Scotland Deanery

    Core Medical Training                        2010-3

    Geriatric Medicine                              2011-5

  • Educational Supervisor, Foundation Programme, GP and Specialty Registrars, 2008-

  • Chair, Medical Specialties Training Committee, North of Scotland Deanery 2013-2015

  • Member, RCP/BGS Geriatric Medicine Specialty Certificate Exam (SCE) Question Writing Group, 2009-14

  • Advisory Board Member, Otsuka Pharmaceuticals (UK), 2010-12

  • Clinical Supervisor, Physician Associate course, 51cg 2013-5

  • ‘Hospital to Home’ National Project Advisory Group Member, Institute for Research and Innovation in Social Services (IRISS), 2013-6

  • Expert panellist, for a number of Delphi expert panels, e.g. for the FORTA, OPERAM and PERFECTED clinical trials

Research

Research Overview

I am interested in all aspects of health and disease in old age. I run clinical trials in a number of areas but specialise in conditions of old age, and trials that need to recruit large number of older people. Since the COVID-19 pandemic, I have been leading my organisation's work on vaccine trials. I have also researched polypharmacy, anticholinergic burden, hyponatraemia, whole body vibration exercise, vascular ageing and cognitive ageing. I have wide experience in epidemiological and physiological studies, as well as systematic reviews and evidence synthesis.

 

 

Research Areas

Applied Health Sciences

  • Supervising

Research Specialisms

  • Clinical Medicine
  • Medicine
  • Pharmacology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Current Research

I am currently leading the Widening Access to Trials in Care Homes (WATCH) project, funded by the Vaccine Innovation Fund. This project will produce best practice guidance in recruiting care home residents into trials of vaccines. This matters because they are an under-represented group in trials, despite being among the worst affected by conditions for which vaccines are being developed, such as respiratory viruses. I am the Principal Investigator of a several clinical studies including Nova-301, Embrace and RSVoice.  

Supervision

My current supervision areas are: Applied Health Sciences.

I have supervised numerous undergraduate and postgraduate students from medical elective students to PhD candidates. 

Funding and Grants

Current Grants

  • 'Widening Access to Trials in Care Homes (WATCH)' RL Soiza, Vaccine Innovation Fund 24/005, £299,792
  • ‘An evidence synthesis suite to inform a a future randomised trial of reducing anticholinergic related harm in older adults’, PK Myint, RL Soiza et al (6 co-investigators), Dunhill Medical Trust Ref No RPGF180666, £99,165

     

    Recent Grants
  • ‘Oral iron, intravenous iron or discontinuation of therapy for older adults with treatment unresponsive iron deficiency anaemia- a pilot randomised controlled trial’, PK Myint, RL Soiza et al (7 co-investigators), CSO Grant Ref No HIPS/17/15, £283,555
  • ‘Development and clinical trials of a new Software ENgine for the Assessment & optimization of drug and non-drug Therapy in Older persons (SENATOR)’, EU FP7 Project Grant, D O’Mahony, RL Soiza et al (12 co-investigators), €5,938,947
  •  ‘Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial’ NIHR HTA Grant 10/71, MD Witham, RL Soiza et al (10 co-investigators), £1,471,735
  •  ‘Vitamin K supplementation to reduce falls in older people – a multicentre trial’ CSO Grant CZH/4/1100, MD Witham, M McMurdo, P Donnan, P Mc Namee, RL Soiza, V Cvoro, £213,493
  • ‘Assessment of association between slow muscle fibres of calf and postural integrity between elderly fallers and non fallers using MRI techniques – a proof of concept study’ NHS Grampian Endowment Fund Research Grant 14/19, PK Myint, SR Gray, J He, RL Soiza,£11,936
  • Vascular ageing and hyponatraemia, NRS Career Researcher Fellowship, £123,010
  •  ‘Association of White Matter Lesions with Endothelial Dysfunction and Postural Blood Pressure Instability (ENDOW Study)’ NHS Grampian Endowment Fund Research Grant, £16,000, GE Hoyle, RL Soiza, DJP Williams, DG Seymour, AD Murray
  • ‘Aberdeen 1936 Birth Cohort Study: Wave 4’ Development Trust Alzheimer’s Research Fund, £41,382, AD Murray, RL Soiza, LJ Whalley
  • 'Association of Postural Blood Pressure Instability with Arterial Stiffness and Endothelial Dysfunction' NHSG Endowments No. 08/26 £8,667, RL Soiza, S Saha, GE Hoyle, DJP Williams
  • ‘The role of serum urate in cognitive decline’ Tenovus Scotland Project Grant G09/20 £9,456, RL Soiza, AD Murray, L Phillips, RT Staff
  • ‘The association between plasma nitrite levels and degree of endothelial function measured by pulse wave analysis’ 50% NHSG Endowments No. 09/19 & 50% British Geriatrics Society SpR Start-up Grant - £13,704, RL Soiza, S Saha, DJP Williams, IJ Megson
  • ‘Arginine Methylation: the missing link between vascular risk and Alzheimer’s disease severity’. NHS Grampian Endowments Research Grant 11/08, £9,084 AA Mangoni, RL Soiza, D Mowat
  • ‘Can asymmetric dimethylarginine (ADMA) predict cognitive decline?’ NHS Grampian Endowments Research Grant No 11/07, £11,789, AA Mangoni, F Thies, RL Soiza, RT Staff

 

Datasets

  • Data From Classifying the non-metabolic demands of different physical activity types: The Physical Activity Demand (PAD) typology

    DOI
    Publisher
    51cg
    Date Made Available
    19 October 2023
    Related Research Outputs
    Contributors
    Roberts, C. (Creator), Phillips, L. (Creator), Cooper, C. (Creator), Gray, S. (Creator), Soiza, R. (Creator), Allan, J. (Creator)
Publications

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  • Editor's View - Falls management and prevention

    Soiza, R.
    Age and Ageing
    Contributions to Journals: Articles
  • Editor’s View – blood based markers for diagnosis of Alzheimer’s disease

    Soiza, R.
    Age and Ageing, vol. 55, no. 8, pp. 1-3
    Contributions to Journals: Editorials
  • Real world experience of attempts to recruit UK care home residents into commercial trials of investigational vaccines – a document analysis of the Widening Access to Trials in Care Homes (WATCH) project

    Soiza, R., Subbarayan, S., Marwick, C. A., Calvert, J., The WATCH Consortium
    Working Papers: Working Papers
  • Anticholinergic Medication Burden Scales: A Systematic Review

    Vennard, O., Stewart, C., Tolia, M., Soiza, R., Myint, P. K.
    Journal of the American Geriatrics Society, vol. 74, no. 6, pp. 1771-1784
    Contributions to Journals: Review articles
  • Barriers and facilitators to recruiting older adult care home residents into clinical trials of medicines and vaccines: a scoping review

    Subbarayan, S., Smith-Dodd, I., Nicolson, G., Burton, J. K., Scott, J. T., Vasan, S. S., Shenkin, S. D., Soiza, R., The WATCH Consortium, Treweek, S., Stewart, C., Macleod, M.
    Age and Ageing, vol. 55, no. 4, afag077
    Contributions to Journals: Articles
  • Editor's view - the pathophysiology of delirium

    Soiza, R.
    Age and Ageing, vol. 55, no. 3, afag055
    Contributions to Journals: Editorials
  • Editor’s View – the value of vaccines for the older person

    Soiza, R.
    Age and Ageing, vol. 55, no. 1, afaf382
    Contributions to Journals: Editorials
  • Identifying what we know about the efficacy of patient empowerment approaches towards deprescribing potentially inappropriate medicine use in older people: a systematic review

    Stewart, C., Soiza, R., Myint, P. K., Mcfall, R., Rasmussen, M., Caie, R.
    Geriatric Pharmacology, 2655007
    Contributions to Journals: Articles
  • Anticholinergic burden and its associated factors among adult outpatients in a resource-limited setting: a cross-sectional study

    Gebreyohannes, E. A., Shibe, B. S., Taye, W. A., Belachew, E. A., Lee, K., Mengistu, S. B., Soiza, R., Myint, P. K., Abubeker Abdela, O.
    Scientific Reports, vol. 15, 44539
    Contributions to Journals: Articles
  • A scoping review of randomised controlled trials of vaccines that recruited care home residents: lessons for future trials

    Subbarayan, S., Smith-Dodd, I., Nicolson, G., Burton, J. K., Vasan, S. S., Shenkin, S. D., Soiza, R., The WATCH Consortium, Treweek, S., Stewart, C., Macleod, M.
    Age and Ageing, vol. 54, no. 12, afaf355
    Contributions to Journals: Articles
  • SCoOP Acute Hospital Outcomes Report: 2022/23

    Myint, P. K., McAlpine, C. H., Donaldson, A., Anand, A., Soiza, R., Mitchell, L., Ramsay, G., Ritchie, L., SCoOP Steering Group
    British Geriatrics Society. 44 pages
    Books and Reports: Commissioned Reports
  • Editor's View - beware claims of efficacy in frailty in cardiovascular trials

    Soiza, R.
    Age and Ageing, vol. 54, no. 12, afaf356
    Contributions to Journals: Editorials
  • Evaluating the Anticholinergic Burden in Older Patients: Comprehensive Insights from a Nationwide Survey Among Emergency Medicine Specialists in the UK

    Dilokthornsakul, P., Stewart, C., Moss, P., Soiza, R., Birse, F., Subbarayan, S., Nakham, A., Kitikannakorn, N., Myint, P. K.
    Geriatrics, vol. 10, no. 6, 137
    Contributions to Journals: Articles
  • Influenza Vaccination in Older Adults: Integral to Good Geriatric Care

    Veronese, N., Soiza, R., Michel, J.
    Age and Ageing, vol. 54, no. 12, afaf365
    Contributions to Journals: Editorials
  • Editor’s View – improving perioperative outcomes in older people’s surgery

    Soiza, R.
    Age and Ageing, vol. 54, no. 10, afaf301
    Contributions to Journals: Editorials
  • Potentially Inappropriate Prescribing Cascades: A new target for deprescribing

    Soiza, R., Mergo, A.
    European Geriatric Medicine, vol. 16, no. 5, pp. 1569–1571
    Contributions to Journals: Editorials
  • Exploring Clinicians Acceptability of a Patient Empowerment approach to Reducing use of Anticholinergic Medicines: The EXPERTISE Study

    Stewart, C., Soiza, R., Myint, P. K.
    Geriatric Pharmacology, vol. 2, no. 1, 2501803
    Contributions to Journals: Articles
  • Delirium And Dementia

    Soiza, R., Butchart, C.
    Prehospital Elderly Care Medicine: A Guide to Assess, Manage and Treat Frail and Geriatric Patients. Etall, R., Gosney, M. (eds.). Springer Nature
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Editor’s View: Updates on safer prescribing

    Soiza, R.
    Age and Ageing, vol. 54, no. 7, afaf200
    Contributions to Journals: Editorials
  • Editing geriatric medicine journals: perspectives from the editors-in-chief of Age and Ageing, European Geriatric Medicine and the Journal of the American Geriatrics Society

    Soiza, R. L., Jentoft, A. J. C., Ouslander, J. G.
    European Geriatric Medicine, vol. 16, no. 3, pp. 727-730
    Contributions to Journals: Editorials
  • Editing geriatric medicine journals: perspectives from the editors-in-chief of Age & Ageing, European Geriatric Medicine and the Journal of the American Geriatrics Society (AA-24-2930)

    Soiza, R., Cruz-Jentoft, A. J., Ouslander, J. G.
    Journal of the American Geriatrics Society, vol. 73, no. 6, pp. 1975-1978
    Contributions to Journals: Editorials
  • Editor’s View – Electronic Frailty Index 2: The Sequel

    Soiza, R.
    Age and Ageing, vol. 54, no. 5, afaf127
    Contributions to Journals: Editorials
  • Editing geriatric medicine journals: perspectives from the editors-in-chief of Age & Ageing, European Geriatric Medicine and the Journal of the American Geriatrics Society (AA-24-2930)

    Soiza, R., Cruz-Jentoft, A. J., Ouslander, J. G.
    Age and Ageing, vol. 54, no. 5, afae294
    Contributions to Journals: Editorials
  • Delirium assessment, management and barriers to effective care across Scotland: A secondary analysis of survey data from World Delirium Awareness Day 2023

    Naeem, F., Penfold, R. S., Soiza, R., Haken, R. V., Lindroth, H., Liu, K., Nydhal, P., Quinn, T. J.
    Journal of the Royal College of Physicians of Edinburgh, vol. 55, no. 1, pp. 6-13
    Contributions to Journals: Articles
  • Editor’s View – Political interference, assisted dying and multicomponent interventions

    Soiza, R.
    Age and Ageing, vol. 54, no. 3, afaf065
    Contributions to Journals: Articles
  • Editor’s View: clustering of multiple problems in individual patients

    Soiza, R.
    Age and Ageing, vol. 54, no. 1, afaf012
    Contributions to Journals: Articles
  • Editor’s View: delirium around the world

    Soiza, R.
    Age and Ageing, vol. 53, afae275
    Contributions to Journals: Editorials
  • Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study

    Gebreyohannes, E. A., Shibe, B. S., Taye, W. A., Lee, K., Abubeker Abdela, O., Ayele, E. M., Belachew, E. A., Mengistu, S. B., Myint, P. K., Soiza, R.
    International Journal of Clinical Pharmacy, vol. 46, no. 6, pp. 1352-1361
    Contributions to Journals: Articles
  • Sex differences in patterns of potentially inappropriate prescribing and adverse drug reactions in hospitalized older people: findings from the SENATOR trial

    O’Mahony, D., Cruz-Jentoft, A. J., Gudmundsson, A., Soiza, R., Petrovic, M., Cherubini, A., Byrne, S., Rochon, P.
    Journal of the American Geriatrics Society, vol. 72, no. 11, pp. 3476-3483
    Contributions to Journals: Articles
  • Enhancing medication management of older adults in Qatar: healthcare professionals’ perspectives on challenges, barriers, and Enabling solutions

    Alyazeedi, A., Stewart, C., Soiza, R., Stewart, D., Awaisu, A., Ryan, C., Alhail, M., Aldarwish, A., Myint, P. K.
    Therapeutic Advances in Drug Safety, vol. 15
    Contributions to Journals: Articles
  • A descriptive analysis of drug-drug interactions and corresponding adverse drug reactions in multimorbid older inpatients: findings from the SENATOR trial

    Ine, S., Annemie, S., Cheima, A., Andreas, C., Cherubini, A., Cruz-Jentoft, A. J., Gudmundsson, A., Soiza, R., O’Mahony, D., Petrovic, M.
    European Geriatric Medicine, vol. 15, pp. 1357–1367
    Contributions to Journals: Articles
  • Editor's View: Ageing in place

    Soiza, R.
    Age and Ageing, vol. 53, no. 9, afae206
    Contributions to Journals: Editorials
  • The association of dementia with incident adverse drug reactions in hospitalized older adults

    Rodriguez-Espeso, E. A., Verdejo-Bravo, C., Cherubini, A., Gudmundsson, A., Petrovic, M., Soiza, R., O'Mahony, D., Cruz-Jentoft, A. J.
    Journal of the American Medical Directors Association, vol. 25, no. 9, 105151
    Contributions to Journals: Articles
  • Why the UK is vaccinating its older adult population against RSV: what geriatricians should know

    Naylor, J., Ho, A., Soiza, R.
    Age and Ageing, vol. 53, no. 9, afae202
    Contributions to Journals: Articles
  • Association of bradykinin receptor 2 (BDKRB2) variants with physical performance and muscle mass: findings from the LACE sarcopenia trial

    Shrestha, A., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T. J., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C. L., Jackson, T. A., Kerr, S., Kilgour, A. H. M., Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Sayer, A. A., Rossios, C., Smith, K. T., Soiza, R., Steves, C. J., Struthers, A. D., Tiwar, D., Whitney, J., Witham, M. D., Kemp, P. R.
    PloS ONE, vol. 19, no. 8, e0307268
    Contributions to Journals: Articles
  • Editor’s View – Updated guidance on managing dementia

    Soiza, R.
    Age and Ageing, vol. 53, no. 8, afae184
    Contributions to Journals: Editorials
  • A world-wide study on delirium assessments and presence of protocols

    Nydahl, P., Liu, K., Bellelli, G., Benbenishty, J., van den Boogaard, M., Caplan, G., Chung, C. R., Elhadi, M., Gurjar, M., Heras-La Calle, G., Hoffmann, M., Jeitziner, M. M., Krewulak, K., Mailhot, T., Morandi, A., Nawa, R. K., Oh, E. S., Collet, M. O., Paulino, M. C., Lindroth, H., von Haken, R., WDAD Study Group, Soiza, R.
    Age and Ageing, vol. 53, no. 7, afae129
    Contributions to Journals: Articles
  • Guideline Summary: Assessment, diagnosis, care, and support for people with dementia and their carers [Scottish Intercollegiate Guidelines Network SIGN Guideline 168]

    Burton, J. K., Soiza, R., Quinn, T. J., SIGN 168 guideline development group
    Age and Ageing, vol. 53, no. 7, afae147
    Contributions to Journals: Articles
  • The COVID-19 Vaccine Gamble – by luck they worked in the oldest, frailest people

    Soiza, R., Niven, M.
    Revista Española de Geriatría y Gerontología, vol. 59, no. 4, 101427
    Contributions to Journals: Editorials
  • Enhancing Medication Safety through implementing the Qatar Tool for Reducing Inappropriate Medication (QTRIM) in Ambulatory Older Adults

    Alyazeedi, A., Sherbash, M., Mohamed, A. F., Stewart, C., Soiza, R., Alhail, M., Aldarwish, A., Stewart, D., Awaisu, A., Ryan, C., Myint, P. K.
    Healthcare, vol. 12, no. 12, 1186
    Contributions to Journals: Articles
  • Editor’s View – Older people’s goals of care and person-centredness

    Soiza, R.
    Age and Ageing, vol. 53, no. 6, afae124
    Contributions to Journals: Editorials
  • A combined approach maximises vaccination rates in older people – health education, centralised reminders and onsite vaccination

    Soiza, R., Khan, Z.
    Age and Ageing, vol. 53, no. 4, afae060
    Contributions to Journals: Articles
  • Should Kuwait Join Global Epidemiological Research for Older People?

    Serri, L. E., Poobalan, A., Soiza, R., Myint, P. K.
    Kuwait Medical Journal, vol. 56, no. 1, pp. 50-53
    Contributions to Journals: Articles
  • Diabetes mellitus increases risk of adverse drug reactions and death in hospitalised older people: the SENATOR trial

    Chinmayee, A., Subbarayan, S., Myint, P. K., Cruz-Jentoft, A. J., Petrovic, M., Gudmundsson, A., Byrne, S., O'Mahony, D., Soiza, R., Cherubini, A.
    European Geriatric Medicine, vol. 15, pp. 189-199
    Contributions to Journals: Articles
  • Anticholinergic burden among in-patients: a cross-sectional study on prevalence, determinants, and impact on mortality in Ethiopia

    Gebreyohannes, E. A., Taye, W. A., Shibe, B. S., Ayele, E. M., Lee, K., Mengistu, S. B., Soiza, R., Myint, P. K., Abubeker Abdela, O.
    Therapeutic Advances in Drug Safety, vol. 15, pp. 1-12
    Contributions to Journals: Articles
  • The predictive role of symptoms in COVID-19 diagnostic models: A longitudinal insight

    Bird, O., Galiza, E. P., Baxter, D. N., Boffito, M., Browne, D., Burns, F., Chadwick, D. R., Clark, R., Cosgrove, C. A., Galloway, J., Goodman, A. L., Heer, A., Higham, A., Iyengar, S., Jeanes, C., Kalra, P., Kyriakidou, C., Bradley, J. M., Munthali, C., Minassian, A. M., McGill, F., Moore, P., Munsoor, I., Nicholls, H., Osanlou, O., Packham, J., Pretswell, C. H., San Francisco Ramos, A., Saralaya, D., Sheridan, R. P., Smith, R., Soiza, R., Swift, P. A., Thomson, E. C., Turner, J., Viljoen, M. E., Heath, P. T., Ster, I. C.
    Epidemiology and Infection, vol. 152, e37
    Contributions to Journals: Articles
  • Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia – analyses from the LACE randomised controlled trial

    Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T. J., Avenell, A., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C. L., Jackson, T., Kerr, S., Kilgour, A. H. M., Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Rossios, C., Sayer, A. A., Smith, K. T., Soiza, R., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D., Kemp, P. R.
    PloS ONE, vol. 18, no. 11 November, e0294330
    Contributions to Journals: Articles
  • ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial

    Rossios, C., Bashir, T., Adamson, S., Adamson, S., Akpan, A., Aspray, T. J., Avenell, A., Band, M. M., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Hume, C. L., Jackson, T. A., Kerr, S., Kilgour, A. H. M., Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Sayer, A. A., Smith, K. T., Soiza, R., Steves, C. J., Struthers, A. D., Tiwari, D., Whitney, J., Witham, M. D., Kemp, P. R.
    PloS ONE, vol. 18, no. 10, e0292402
    Contributions to Journals: Articles
  • Classifying the non-metabolic demands of different physical activity types: The Physical Activity Demand (PAD) typology

    Roberts, C., Phillips, L., Cooper, C., Gray, S., Soiza, R., Allan, J.
    PloS ONE, vol. 18, no. 10, e0291782
    Contributions to Journals: Articles
  • Poor outcomes in patients with sepsis undergoing emergency laparotomy and laparoscopy are attenuated by faster time to care measures

    Eiamampai, N., Ramsay, E. A., Soiza, R. L., McDonald, D. A., Moug, S. J., Myint, P. K.
    Colorectal Disease, vol. 25, no. 9, pp. 1888-1895
    Contributions to Journals: Articles
  • A systematic review of clinical practice guidelines on the use of deep brain stimulation for the treatment of obsessive compulsive disorder

    Mazzoleni, A., Bhatia, S., Bantounou, M. A., Kumar, N. S., Dzalto, M., Soiza, R.
    International Congress of Royal College of Psychiatrist, pp. S60-S61
    Contributions to Journals: Abstracts
  • SCoOP Acute Hospitals Outcomes Reports: An overview of outcomes of acute geriatric medicine services in Scotland before, during and after the covid lockdown

    Soiza, R., Premathilaka, C., McAlpine, C. H., Myint, P. K.
    Commissioned by British Geriatrics Society. 51cg. 48 pages
    Books and Reports: Commissioned Reports
  • Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group. Electronic address: recoverytrial@ndph.ox.ac.uk, Cooper, J., Soiza, R., Bateman, V., Black, M., Brittain-Long, R., Collie, K., Counter, D., Coutts, A., Devkota, S., Dospinescu, P., Flett, F., Ganley, P., Hunter, R., Irvine, J., Kane, L., Kaye, C., Khan, A., Laing, R., MacKenzie, A., Macleod, M., McLay, J., Noble, J., Norris, K., Taylor, V., Tonna, I., Vileito, A., Walker, L., Hornby, P. W., Landray, M. J.
    Lancet (London, England), vol. 401, no. 10387, pp. 1499-1507
    Contributions to Journals: Articles
  • Virus Infections in Older People

    Soiza, R., Scicluna, C., Bilal, S.
    Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Harris, R. (ed.). 1 edition. Springer Nature, pp. 149–183, 35 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Editor’s view: Cardiovascular health and frailty

    Soiza, R. L.
    Age and Ageing, vol. 52, no. 2, afad029
    Contributions to Journals: Editorials
  • Safety and Efficacy of the NVX-CoV2373 Coronavirus Disease 2019 Vaccine at Completion of the Placebo-Controlled Phase of a Randomized Controlled Trial

    Heath, P. T., Galiza, E. P., Baxter, D. N., Boffito, M., Browne, D., Burns, F., Chadwick, D. R., Clark, R., Cosgrove, C. A., Galloway, J., Goodman, A. L., Heer, A., Higham, A., Iyengar, S., Jeanes, C., Kalra, P. A., Kyriakidou, C., Bradley, J. M., Munthali, C., Minassian, A. M., McGill, F., Moore, P., Munsoor, I., Nicholls, H., Osanlou, O., Packham, J., Pretswell, C. H., Francisco Ramos, A. S., Saralaya, D., Sheridan, R. P., Smith, R., Soiza, R. L., Swift, P. A., Thomson, E. C., Turner, J., Viljoen, M. E., Fries, L., Cho, I., McKnight, I., Glenn, G., Rivers, E. J., Robertson, A., Alves, K., Smith, K., Toback, S.
    Clinical Infectious Diseases, vol. 76, no. 3, pp. 398-407
    Contributions to Journals: Articles
  • The Relationship Between Nutritional Status at the Time of Stroke on Adverse Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

    de Paola, L., Pana, T., Carter, B., Soiza, R., Kafri, M. W., Potter, J. F., Mamas, M. A., Myint, P. K., Mehta, A.
    Nutrition Reviews, vol. 80, no. 12, pp. 2275-2287
    Contributions to Journals: Articles
  • Does estimated glomerular filtration rate predict in-hospital mortality in acutely unwell hospitalized oldest old?

    Wakerly, Z. R., Soiza, R., Pana, T., Myint, P. K.
    Geriatrics, vol. 7, no. 6, 135
    Contributions to Journals: Articles
  • Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis

    RECOVERY Collaborative Group, Cooper, J., Soiza, R.
    The Lancet, vol. 400, no. 10349, pp. 359-368
    Contributions to Journals: Articles
  • Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine

    Hager, K. J., Pérez Marc, G., Gobeil, P., Diaz, R. S., Heizer, G., Llapur, C., Makarkov, A. I., Vasconcellos, E., Pillet, S., Riera, F., Saxena, P., Geller Wolff, P., Bhutada, K., Wallace, G., Aazami, H., Jones, C. E., Polack, F. P., Ferrara, L., Atkins, J., Boulay, I., Dhaliwall, J., Charland, N., Couture, M. M. J., Jiang-Wright, J., Landry, N., Lapointe, S., Lorin, A., Mahmood, A., Moulton, L. H., Pahmer, E., Parent, J., Séguin, A., Tran, L., Breuer, T., Ceregido, M., Koutsoukos, M., Roman, F., Namba, J., D'Aoust, M., Trepanier, S., Kimura, Y., Ward, B. J., CoVLP Study Team, Soiza, R.
    The New England Journal of Medicine, vol. 386, pp. 2084-2096
    Contributions to Journals: Articles
  • Comparison of the Clinical Frailty Score (CFS) to the National Emergency Laparotomy Audit (NELA) Risk Calculator in all patients undergoing emergency laparotomy.

    Palaniappan, S., Soiza, R., Duffy, S., Moug, S., Myint, P. K., The Emergency Laparoscopic and Laparotomy Scottish Audit (ELLSA).
    Colorectal Disease, vol. 24, no. 6, pp. 782-789
    Contributions to Journals: Articles
  • Editor’s view

    Soiza, R.
    Age and Ageing, vol. 51, no. 5, afac122
    Contributions to Journals: Editorials
  • Body Mass Index and Mortality, Recurrence and Readmission after Myocardial Infarction: Systematic Review and Meta-analysis

    de Paola, L., Mehtav, A., Pana, T., Carter, B., Soiza, R., Kafri, M. W., Potter, J. F., Mamas, M. A., Myint, P. K.
    Journal of Clinical Medicine, vol. 11, no. 9, 2581
    Contributions to Journals: Articles
  • Effect of perindopril or leucine on physical performance in older people with sarcopenia: the LACE randomized controlled trial

    Achison, M., Adamson, S., Akpan, A., Aspray, T., Avenell, A., Band, M. M., Bashir, T., Burton, L. A., Cvoro, V., Donnan, P. T., Duncan, G. W., George, J., Gordon, A. L., Gregson, C. L., Hapca, A., Henderson, E., Hume, C., Jackson, T. A., Kemp, P., Kerr, S., Kilgour, A., Lyell, V., Masud, T., McKenzie, A., McKenzie, E., Patel, H., Pilvinyte, K., Roberts, H. C., Rossios, C., Sayer, A. A., Smith, K. T., Soiza, R. L., Steves, C. J., Struthers, A. D., Sumukadas, D., Tiwari, D., Whitney, J., Witham, M. D., LACE study group
    Journal of Cachexia, Sarcopenia and Muscle, vol. 13, no. 2, pp. 858-871
    Contributions to Journals: Articles
  • Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Cooper, J., Soiza, R.
    The Lancet, vol. 399, no. 10325, pp. 665-676
    Contributions to Journals: Articles
  • Frailty is associated with increased waiting time for relevant process of care measures; findings from the Emergency Laparoscopic & Laparotomy Scottish Audit (ELLSA)

    Ramsay, E., Carter, B., Soiza, R., Duffy, S., Moug, S., Myint, P. K.
    British Journal of Surgery, vol. 109, no. 2, pp. 172–175
    Contributions to Journals: Articles
  • Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a randomised, observer-blinded, placebo-controlled, phase 3 trial

    Toback, S., Galiza, E., Cosgrove, C., Galloway, J., Goodman, A. L., Swift, P. A., Rajaram, S., Graves-Jones, A., Edelman, J., Burns, F., Minassian, A. M., Cho, I., Kumar, L., Plested, J. S., Rivers, E. J., Robertson, A., Dubovsky, F., Glenn, G., Heath, P. T., 2019nCoV-302 Study Group, Soiza, R.
    The Lancet. Respiratory medicine, vol. 10, no. 2, pp. 167-179
    Contributions to Journals: Articles
  • Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Cooper, J., Soiza, R.
    The Lancet, vol. 399, no. 10320, pp. 143-151
    Contributions to Journals: Articles
  • Editorial: Deprescribing and Minimizing Use of Anticholinergic Medications

    Soiza, R., Boustani, M., Campbell, N. L., Mangoni, A.
    Frontiers in Pharmacology, vol. 12, 820051
    Contributions to Journals: Articles
  • An international consensus list of potentially clinically significant drug-drug interactions in older people

    Anrys, P., Petit, A., Thevelin, S., Sallevelt, B., Drenth, C., Soiza, R., Correa-Pérez, A., Dalleur, O., De Brauwer, I., Petrovic, M., Coleman, J., Dalton, K., O’Mahony, D., Löwe, J., Thürig, S., Gudmundsson, A., Cherubin, A., Panos, A., Mavridis, D., Rodondi, N., Spinewine, A.
    Journal of the American Medical Directors Association, vol. 22, no. 10, pp. 2121-2133.e24
    Contributions to Journals: Articles
  • Associations between Frailty, Physical Performance, and Renal Biomarkers in Older People with Advanced Chronic Kidney Disease

    Smith, G., Avenell, A., Band, M. M., Hampson, G., Lamb, E. J., Littleford, R. C., McNamee, P., Soiza, R., Sumukadas, D., Witham, M. D.
    European Geriatric Medicine, vol. 12, pp. 943–952
    Contributions to Journals: Articles
  • Safety and Efficacy of the NVX-CoV2373 Covid-19 Vaccine

    Heath, P. T., Galiza, E. P., Baxter, D. N., Boffito, M., Browne, D., Burns, F., Chadwick, D. R., Clarke, R., Cosgrove, C., Galloway, J. N., Goodman, A. L., Higham, A., Iyengar, S., Jamal, A., Jeanes, C., Kalra, P., Kyriakidou, C., McAuley, D. F., Meyrick, A., Minassian, A. M., Minton, J., Moore, P., Munsoor, I., Nicholls, H., Osanlou, O., Packham, J., Pretswell, C. H., San Francisco Ramos, A., Saralaya, D., Sheridan, R. P., Smith, R., Soiza, R., Swift, P. A., Thomson, E. C., Turner, J., Viljoen, M. E., Albert, G., Cho, I., Dubovsky, F., Glenn, G., Rivers, J., Robertson, A., Smith, K., Toback, S., 2019nCoV-302 Study Group
    The New England Journal of Medicine, vol. 385, no. 13, pp. 1172-1183
    Contributions to Journals: Articles
  • Hyponatraemia in older people is usually multifactorial and commonly iatrogenic

    Soiza, R.
    Age and Ageing, vol. 50, no. 4, pp. 1071-1072
    Contributions to Journals: Editorials
  • Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R., Cooper, J.
    The Lancet, vol. 397, no. 10289, pp. 2049-2059
    Contributions to Journals: Articles
  • Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R., Macleod, M., Cooper, J.
    The Lancet, vol. 397, no. 10285, pp. 1637-1645
    Contributions to Journals: Articles
  • Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome (Review)

    Taylor-Rowan, M., Edwards, S., Noel-Storr, A. H., McCleery, J., Myint, P. K., Soiza, R., Stewart, C., Loke, Y. K., Quinn, T. J.
    Cochrane Database of Systematic Reviews, vol. 5, no. 4, CD013540
    Contributions to Journals: Articles
  • 503 Clinical Frailty Score (CFS) Vs Antibiotics, Time to Surgery and Time to Computerised Tomography (CT) Scan in An Emergency Surgical Population

    Palaniappan, S., Soiza, R., Moug, S., Myint, P.
    British Journal of Surgery, vol. 108, no. Supplement_2, znab134.193
    Contributions to Journals: Abstracts
  • WHAT ARE THE ASSOCIATIONS BETWEEN RENAL BIOCHEMISTRY AND PHYSICAL PERFORMANCE IN OLDER PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE? FINDINGS FROM THE BICARB TRIAL COHORT

    Witham, M. D., Lamb, E. J., Sumukadas, D., Band, M. M., Soiza, R. L., Hampson, G., McNamee, P., Avenell, A.
    Age and Ageing, vol. 50, no. Supp 1, 47
    Contributions to Journals: Abstracts
  • Development of a European consensus from dentists, dental hygienists and physicians on a standard for oral health care in care‐dependent older people: an e-Delphi study

    Charadram, N., Maniewicz, S., Maggi, S., Petrovic, M., Kossioni, A., Srinivasan, M., Schimmel, M., Mojon, P., Müller, F., e-Delphi working group, Soiza, R.
    Gerodontology, vol. 38, no. 1, pp. 41-56
    Contributions to Journals: Articles
  • Efficacy and safety of COVID-19 vaccines in older people

    Soiza, R. L., Scicluna, C., Thomson, E. C.
    Age and Ageing, vol. 50, no. 2, pp. 279–283
    Contributions to Journals: Articles
  • SCoOP Acute Hospital Outcomes Report 2018-2019: An overview of outcomes of acute geriatric medicine services in Scotland

    Soiza, R., Scicluna, C., Myint, P. K., SCoOP Steering Group
    51cg. 40 pages
    Books and Reports: Commissioned Reports
  • Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R., Cooper, J.
    The Lancet, vol. 397, no. 10274, pp. 605-612
    Contributions to Journals: Articles
  • Bioelectrical impedance versus biochemical analysis of hydration status: predictive value for prolonged hospitalisation and poor discharge destination in older patients

    Wood, A. D., Edward, G. D., Cumming, K., Kafri, M., Soiza, R. L., Hooper, L., Potter, J. F., Myint, P. K.
    Healthcare, vol. 9, no. 2, 154
    Contributions to Journals: Articles
  • Baseline anticholinergic burden from medications predicts poorer baseline and long-term health-related quality of life in 16 675 men and women of EPIC-Norfolk prospective population-based cohort study

    Yrjana, K. R., Neal, S. R., Soiza, R. L., Keevil, V., Luben, R. N., Wareham, N. J., Khaw, K., Myint, P. K.
    Pharmacoepidemiology and Drug Safety, vol. 30, no. 2, pp. 135-143
    Contributions to Journals: Articles
  • Anticholinergic Burden Measures Predict Older People’s Physical Function and Quality of Life: A Systematic Review

    Stewart, C., Yrjana, K., Kisshor, M., Soiza, R. L., Taylor-Rowan, M., Quinn, T. J., Loke, Y. K., Myint, P. K.
    Journal of the American Medical Directors Association, vol. 22, no. 1, pp. 56-64
    Contributions to Journals: Articles
  • Anticholinergic burden measures and older people's falls risk: a systematic prognostic review.

    Stewart, C., Taylor-Rowan, M., Soiza, R., Quinn, T. J., Loke, Y. K., Myint, P. K.
    Therapeutic Advances in Drug Safety, vol. 12, pp. 1-10
    Contributions to Journals: Articles
  • Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

    Horby, P., Mafham, M., Linsell, L., Bell, J. L., Staplin, N., Emberson, J. R., Wiselka, M., Ustianowski, A., Elmahi, E., Prudon, B., Whitehouse, T., Felton, T., Williams, J., Faccenda, J., Underwood, J., Baillie, J. K., Chappell, L. C., Faust, S. N., Jaki, T., Jeffery, K., Lim, W. S., Montgomery, A., Rowan, K., Tarning, J., Watson, J. A., White, N. J., Juszczak, E., Haynes, R., Landray, M. J., RECOVERY Collaborative Group, Cooper, J., Soiza, R.
    The New England Journal of Medicine, vol. 383, no. 21, pp. 2030-2040
    Contributions to Journals: Articles
  • Global pandemic - the true incidence of adverse drug reactions

    Soiza, R.
    Age and Ageing, vol. 49, no. 6, pp. 934-935
    Contributions to Journals: Editorials
  • Circulating asymmetric dimethylarginine and cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort

    Malden, D. E., Mangoni, A. A., Woodman, R. J., Thies, F., McNeil, C., Murray, A. D., Soiza, R. L.
    International Journal of Geriatric Psychiatry, vol. 35, no. 10, pp. 1181-1188
    Contributions to Journals: Articles
  • Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group, Soiza, R., Cooper, J.
    The Lancet, vol. 396, no. 10259, pp. 1345-1352
    Contributions to Journals: Articles
  • Dexamethasone in Hospitalized Patients with Covid-19: Preliminary Report

    Horby, P., Lim, W. S., Emberson, J. R., Mafham, M., Bell, J. L., Linsell, L., Staplin, N., Brightling, C., Ustianowski, A., Elmahi, E., Prudon, B., Green, C., Felton, T., Chadwick, D., Rege, K., Fegan, C., Chappell, L. C., Faust, S. N., Jaki, T., Jeffery, K., Montgomery, A., Rowan, K., Juszczak, E., Baillie, J. K., Haynes, R., Landray, M. J., RECOVERY Collaborative Group, Cooper, J., Soiza, R.
    The New England Journal of Medicine, vol. 384, no. 8, pp. 693-704
    Contributions to Journals: Articles
  • Prevention of Adverse Drug Reactions in Hospitalized Older Patients with Multi-morbidity and Polypharmacy: the SENATOR randomized controlled clinical trial

    O’Mahony, D., Gudmundsson, A., Soiza, R. L., Petrovic, M., Jose Cruz-Jentoft, A., Cherubini, A., Fordham, R., Byrne, S., Dahly, D., Gallagher, P., Lavan, A., Curtin, D., Dalton, K., Cullinane, S., Flanagan, E., Shiely, F., Samuelsson, ?., Sverrisdóttir, ?., Subbarayan, S., Vandaele, L., Meireson, E., Montero-Errasquín, B., Rexach-Cano, A., Correa-Pérez, A., Lozano-Montoya, I., Vélez-Díaz-Pallarés, M., Cerenzia, A., Corradi, S., Soledad Cotorruelo Ferreiro, M., Dimitri, F., Marinelli, P., Martelli, G., Fong Soe Khioe, R., Eustace, J.
    Age and Ageing, vol. 49, no. 4, pp. 605-614
    Contributions to Journals: Articles
  • COVID-19 position statement: Presentations and management of COVID-19 in older people in acute care

    Ellis, G., Beattie, J., Burns, J., Cantley, P., Coull, A., MacInnes, C., McDonald, C., McIlgorm, M., McKenzie, A., Mitchell, L., Murray, D., Nairn, M., Shenkin, S., Soiza, R., Wallace, R., Witham, M.
    Scottish Government. 14 pages
    Books and Reports: Commissioned Reports
  • The prognostic value of anticholinergic burden measures in relation to mortality in older individuals: a systematic review and meta-analysis

    Graves-Morris, K., Stewart, C., Soiza, R. L., Taylor-Rowan, M., Quinn, T. J., Loke, Y. K., Myint, P. K.
    Frontiers in Pharmacology, vol. 11, 570
    Contributions to Journals: Articles
  • Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial

    Witham, M. D., McNamee, P., Soiza, R., Avenell, A., BiCARB Study Group
    BMC medicine , vol. 18, 91
    Contributions to Journals: Articles
  • Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis: The BiCARB randomised controlled trial

    Witham, M. D., Band, M., Chong, H. Y., Donnan, P. T., Hampson, G., Hu, M. K., Littleford, R., Lamb, E., Kalra, P., Kennedy, G., McNamee, P., Plews, D., Rauchhaus, P., Soiza, R. L., Sumukadas, D., Warwick, G., Avenell, A.
    Health Technology Assessment, vol. 18, 91
    Contributions to Journals: Articles
  • Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties

    Hanlon, P., Quinn, T. J., Gallacher, K., Myint, P. K., Jani, B. D., Nicholl, B. I., Lowrie, R., Soiza, R. L., Neal, S. R., Lee, D., Mair, F.
    Annals of Family Medicine, vol. 18, no. 2, pp. 148-155
    Contributions to Journals: Articles
  • Non-pharmacological, non-surgical interventions for urinary incontinence in older persons: A systematic review of systematic reviews. The SENATOR project ONTOP series

    Kilpatrick, K. A., Paton, P., Subbarayan, S., Stewart, C., Abraha, I., Cruz-Jentoft, A. J., O’Mahony, D., Cherubini, A., Soiza, R. L.
    Maturitas, vol. 133, pp. 42-48
    Contributions to Journals: Articles
  • Association between different methods of assessing blood pressure variability and incident cardiovascular disease, cardiovascular mortality and all-cause mortality: a systematic review

    Smith, T. O., Sillito, J. A., Goh, C., Abdel-Fattah, A., Einarsson, A., Soiza, R. L., Mamas, M. A., Tan, M. P., Potter, J. F., Loke, Y. K., Myint, P. K.
    Age and Ageing, vol. 49, no. 2, pp. 184-192
    Contributions to Journals: Review articles
  • Effect of vitamin K2 on postural sway in older people who fall: a randomised controlled trial

    Witham, M. D., Price, R. J. G., Band, M. M., Hannah, M. S., Fulton, R. L., Clarke, C. L., Donnan, P. T., McNamee, P., Cvoro, V., Soiza, R. L.
    Journal of the American Geriatrics Society, vol. 67, no. 10, pp. 2102-2107
    Contributions to Journals: Articles
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