51cg

People

Dr Roger Staff

Dr Roger Staff
Dr Roger Staff
Dr Roger Staff

BSc MSc PhD MIPEM

Honorary Professor

51cg
Email Address
r.staff@abdn.ac.uk
Office Address

Nuclear Medicine ARI Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Roger Staff was born in London and studied physics at UEA.  He moved to Aberdeen in 1988 and completed his PhD in medical physics in 1994.  He has worked for the NHS since 1991 and currently leads the clinical physics imaging team at NHS-Grampian. His other interests include Intelligence and social mobility.

Research

Research Overview

(Since 1999) founding member of the Aberdeen 1921 & 1936 birth cohort study group with three critical responsibilities for (1) hypothesis generation and hypothesis testing; (2) brain imaging and image analysis; (3) Advance data modelling of complex databases; (Since 2003 with Taurx) the imaging the effects tau aggregation inhibition and the use of surrogate imaging measures in drug development; (Since 2008) the development of structural and temporal (fMRI) complexity measures for use in ageing and neurodegenerative disease; (Since 2012) The prognostic value of automated analysis of sequential retinal images in diabetic retinopathy. The use of external quality assurance programs in diabetic retinopathy.   

Publications

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  • Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer’s disease with hydromethylthionine mesylate using external control data

    Schelter, B. O., Shiells, H., Lo, S., Nazlee, N., Evans, E., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M., Baddeley, T., Harrington, C. R., Staff, R., Sandu, A., Hull, C., Stefanacci, R., Wischik, C. M., Alzheimer's Disease Neuroimaging Initiative
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 6, 100560
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease

    Wischik, C. M., Stefanacci, R., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M. D., Baddeley, T., Harrington, C. R., Penny, L. K., Arastoo, M., Staff, R., Sandu, A., Shiells, H., Lo, S., Nazlee, N., Evans, E., Hull, C., Schelter, B. O.
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning

    Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.
    Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Impact of Different Mammography Systems on Artificial Intelligence Performance in Breast Cancer Screening

    de Vries, C., Colosimo, S., Staff, R., Dymiter, J., Yearsley, J., Dinneen, D., Boyle, M., Harrison, D., Anderson, L., Lip, G.
    Radiology: Artificial Intelligence, vol. 5, no. 3, e220146
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • AI in breast screening mammography: breast screening readers' perspectives

    de Vries, C. F., Colosimo, S. J., Boyle, M., Lip, G., Anderson, L. A., Staff, R. T., iCAIRD Radiology Collaboration
    Insights into Imaging, vol. 13, no. 1, 186
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The Role of redo-Sentinel Lymph Node Biopsy in Patients With Prior Ipsilateral Breast Cancer Surgery

    Macnab, M. R. F., Slater, G., Fuller, M., Elsberger, B., Lovell, L., Staff, R. T., Masannat, Y. A.
    Clinical Breast Cancer, vol. 22, no. 5, pp. e674-e679
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study

    Sandu, A., Waiter, G. D., Staff, R. T., Nazlee, N., Habota, T., McNeil, C. J., Chapko, D., Williams, J. H., Fall, C. H. D., Chandak, G. R., Pene, S., Krishna, M., McIntosh, A. M., Whalley, H. C., Kumaran, K., Krishnaveni, G. V., Murray, A. D.
    Scientific Reports, vol. 12, 11025
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cognitive Test Scores and Progressive Cognitive Decline in the Aberdeen 1921 and 1936 Birth Cohorts

    Whalley, L. J., Staff, R. T., Lemmon, H., Fox, H. C., McNeil, C., Murray, A. D.
    Brain Sciences, vol. 12, no. 3, 318
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

    Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.
    Brain Communications, vol. 3, no. 4, fcab241
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier

    Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Screening participants’ attitudes to the introduction of artificial intelligence in breast screening

    Vries, C. F. d., Morrissey, B. E., Duggan, D., Staff, R. T., Lip, G.
    Journal of Medical Screening, vol. 28, no. 3, pp. 221-222
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • IQ tests: are humans getting smarter?

    Staff, R., Whalley, L.
    The Conversation
    Contributions to Specialist Publications: Articles
    • [ONLINE]

  • Imprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life

    Ritchie, M., Murray, A., Staff, R., Ferguson-Smith, A. C., Richards, M., Horgan, G. W., Phillips, L., Hoad, G., McNeil, C., Ribeiro, A., Haggarty, P.
    Scientific Reports, vol. 11, 943
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Aspirin moderates the association between cardiovascular risk, brain white matter hyperintensity total lesion volume and processing speed in normal ageing

    Khezrian, M., Waymont, J. M., Myint, P. K., McNeil, C. J., Whalley, L., Staff, R., Murray, A. D.
    Maturitas, vol. 133, pp. 49-53
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Klotho gene polymorphism, brain structure and cognition in early-life development

    de Vries, C. F., Staff, R., Noble, K. G., Muetzel, R. L., Vernooij, M. W., White, T., Waiter, G. D., Murray, A. D.
    Brain Imaging and Behavior, vol. 14, pp. 213-225
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Motion during Acquisition is Associated with fMRI Brain Entropy

    de Vries, C., Staff, R. T., Waiter, G. D., Sokunbi, M. O., Sandu, A. L., Murray, A. D.
    IEEE journal of biomedical and health informatics, vol. 24, no. 2, pp. 586-593
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]
    • [ONLINE]

  • Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

    Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

    Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.
    International Journal of Neural Systems, vol. 29, no. 6, 1850055
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Does problem-solving really protect against cognitive decline in old age?

    Staff, R., Whalley, L., Hogan, M. J.
    The Conversation
    Contributions to Specialist Publications: Articles
    • [ONLINE]

  • Intellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture): Longitudinal, prospective study

    Staff, R. T., Hogan, M. J., Williams, D. S., Whalley, L. J.
    BMJ (Online), vol. 363, k4925
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • The influence of childhood intelligence, social class, education and social mobility on memory and memory decline in late life

    Staff, R. T., Hogan, M. J., Whalley, L. J.
    Age and Ageing, vol. 47, no. 6, pp. 847-852
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Distribution of retinal microaneurysms in diabetic retinopathy using automated retinal image analysis

    Pitts, S., Philip, S., Prescott, G., Ahmed, A., Xu, J., Staff, R., Sharp, P., Olson, J.
    Diabetic Medicine, vol. 35, no. S1, pp. 182
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing

    McNeil, C. J., Myint, P. K., Sandu-Giuraniuc, A., Potter, J. F., Staff, R., Whalley, L. J., Murray, A. D.
    Age and Ageing, vol. 47, no. 1, pp. 95-100
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review

    Chapko, D., McCormack, R., Black, C., Staff, R., Murray, A.
    Aging & Mental Health, vol. 22, no. 8, pp. 915-926
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]
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