51cg

People

Dr Stephen Makin

Dr Stephen Makin
Dr Stephen Makin
Dr Stephen Makin

MBChB, FRCP, PhD

Senior Lecturer (Clinical)

51cg
Email Address
stephen.makin@abdn.ac.uk
Office Address

Centre for Rural Health 
The Centre for Health Science
Old Perth Road
Inverness
IV2 3JH

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

As well as my clinical academic work, I am a geriatrician with my clinical practice at Catihness General Hospital in Wick a small rural hospital in the far north of Scotland. 

After training at the University of Birmingham, and post graduate training in North West England, I moved to Scotland to do a Clinical Research fellow post at the University of Edinburgh. My PhD focused on small vessel disease. Diffuse vascular disease that is very common in older people, and is responsible for vascular dementia, lacunar stroke, gait instablity as well as other co-morbidities. 

I am still interested in stroke but in addition I am now also investigating the  best way to deliever health care to frail elderly patients in remote and rural areas. 

I am always keen to collaborate and welcome enquires from prospective collaborators and research students. 

Publications

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  • The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

    Loos, C. M., McHutchison, C., Cvoro, V., Makin, S. D., Staals, J., Chappell, F., Dennis, M., van Oostenbrugge, R. J., Wardlaw, J. M.
    International Journal of Stroke, vol. 13, no. 5, pp. 518-524
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review

    Makin, S. D. J., Mubki, G. F., Doubal, F. N., Shuler, K., Staals, J., Dennis, M. S., Wardlaw, J. M.
    Journal of Stroke and Cerebrovascular Diseases, vol. 26, no. 12, pp. 3020-3028
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • White matter hyperintensity reduction and outcomes after minor stroke

    Wardlaw, J. M., Chappell, F. M., Valdes Hernandez, M. d. C., Makin, S. D. J., Staals, J., Shuler, K., Thrippleton, M. J., Armitage, P. A., Munoz-Maniega, S., Heye, A. K., Sakka, E., Dennis, M. S.
    Neurology, vol. 89, no. 10, pp. 1003-1010
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity

    Valdes Hernandez, M. d. C., Gonzalez-Castro, V., Chappell, F. M., Sakka, E., Makin, S., Armitage, P. A., Nailon, W. H., Wardlaw, J. M.
    Frontiers in Neurology, vol. 8, 327
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance

    Gonzalez-Castro, V., Valdes Hernandez, M. d. C., Chappell, F. M., Armitage, P. A., Makin, S., Wardlaw, J. M.
    Clinical Science, vol. 131, no. 13, pp. 1465-1481
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

    Wardlaw, J. M., Makin, S. J., Valdés Hernández, M. C., Armitage, P. A., Heye, A. K., Chappell, F. M., Muñoz-Maniega, S., Sakka, E., Shuler, K., Dennis, M. S., Thrippleton, M. J.
    Alzheimer's and Dementia, vol. 13, no. 6, pp. 634-643
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

    Chappell, F. M., Valdes Hernandez, M. d. C., Makin, S. D., Shuler, K., Sakka, E., Dennis, M. S., Armitage, P. A., Munoz Maniega, S., Wardlaw, J. M.
    Trials, vol. 18, 78
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease

    Munoz Maniega, S., Chappell, F. M., Valdes Hernandez, M. C., Armitage, P. A., Makin, S. D., Heye, A. K., Thrippleton, M. J., Sakka, E., Shuler, K., Dennis, M. S., Wardlaw, J. M.
    Journal of Cerebral Blood Flow and Metabolism, vol. 37, no. 2, pp. 644-656
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

    Sachdev, P. S., Lo, J. W., Crawford, J. D., Mellon, L., Hickey, A., Williams, D., Bordet, R., Mendyk, A., Gele, P., Deplanque, D., Bae, H., Lim, J., Brodtmann, A., Werden, E., Cumming, T., Kohler, S., Verhey, F. R. J., Dong, Y., Tan, H. H., Chen, C., Xin, X., Kalaria, R. N., Allan, L. M., Akinyemi, R. O., Ogunniyi, A., Klimkowicz-Mrowiec, A., Dichgans, M., Wollenweber, F. A., Zietemann, V., Hoffmann, M., Desmond, D. W., Linden, T., Blomstrand, C., Fagerberg, B., Skoog, I., Godefroy, O., Barbay, M., Roussel, M., Lee, B., Yu, K., Wardlaw, J., Makin, S. J., Doubal, F. N., Chappell, F. M., Srikanth, V. K., Thrift, A. G., Donnan, G. A., Kandiah, N., Chander, R. J., Lin, X., Cordonnier, C., Moulin, S., Rossi, C., Sabayan, B., Stott, D. J., Jukema, J. W., Melkas, S., Jokinen, H., Erkinjuntti, T., Mok, V. C. T., Wong, A., Lam, B. Y. K., Leys, D., Henon, H., Bombois, S., Lipnicki, D. M., Kochan, N. A.
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 7, pp. 11-23
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

    Shi, Y., Thrippleton, M. J., Makin, S. D., Marshall, I., Geerlings, M. I., de Craen, A. J., van Buchem, M. A., Wardlaw, J. M.
    Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 10, pp. 1653-1667
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Response to Letter Regarding Article, "Clinically Confirmed Stroke With Negative Diffusion-Weighted Imaging Magnetic Resonance Imaging: Longitudinal Study of Clinical Outcomes, Stroke Recurrence, and Systematic Review"

    Makin, S. D., Wardlaw, J. M.
    Stroke, vol. 47, no. 3, pp. e54
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability

    Heye, A. K., Thrippleton, M. J., Armitage, P. A., Valdes Hernandez, M. d. C., Makin, S. D., Glatz, A., Sakka, E., Wardlaw, J. M.
    Neuroimage, vol. 125, pp. 446-455
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease

    Heye, A. K., Thrippleton, M. J., Chappell, F. M., Hernandez Mdel, C., Armitage, P. A., Makin, S. D., Maniega, S. M., Sakka, E., Flatman, P. W., Dennis, M. S., Wardlaw, J. M.
    Journal of Cerebral Blood Flow and Metabolism, vol. 36, no. 1, pp. 264-274
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • A comparison of location of acute symptomatic vs. 'silent' small vessel lesions

    Valdes Hernandez, M. d. C., Maconick, L. C., Munoz Maniega, S., Wang, X., Wiseman, S., Armitage, P. A., Doubal, F. N., Makin, S., Sudlow, C. L., Dennis, M. s., Deary, I. J., Bastin, M., Wardlaw, J. M.
    International Journal of Stroke, vol. 10, no. 7, pp. 1044-1050
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Clinically Confirmed Stroke With Negative Diffusion-Weighted Imaging Magnetic Resonance Imaging: Longitudinal Study of Clinical Outcomes, Stroke Recurrence, and Systematic Review

    Makin, S. D., Doubal, F. N., Dennis, M. S., Wardlaw, J. M.
    Stroke, vol. 46, no. 11, pp. 3142-3148
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cerebral small vessel disease and renal function: systematic review and meta-analysis

    Makin, S. D. J., Cook, F. A. B., Dennis, M. S., Wardlaw, J. M.
    Cerebrovascular Diseases, vol. 39, no. 1, pp. 39-52
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden

    Staals, J., Makin, S. D., Doubal, F. N., Dennis, M. S., Wardlaw, J. M.
    Neurology, vol. 83, no. 14, pp. 1228-1234
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Predicting delirium after a stroke

    Makin, S. D., Wardlaw, J.
    Journal of Neurology, Neurosurgery & Psychiatry, vol. 85, no. 4, 357
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Variation in risk factors for recent small subcortical infarcts with infarct size, shape, and location

    Del Bene, A., Makin, S. D. J., Doubal, F. N., Inzitari, D., Wardlaw, J. M.
    Stroke, vol. 44, no. 11, pp. 3000-3006
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:

  • Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes

    Makin, S. D. J., Turpin, S., Dennis, M. S., Wardlaw, J. M.
    Journal of Neurology, Neurosurgery & Psychiatry, vol. 84, no. 8, pp. 893-900
    Contributions to Journals: Articles
    • [ONLINE]
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Dystypia in acute stroke not attributable to aphasia or neglect

    Cook, F. A. B., Makin, S. D. J., Wardlaw, J., Dennis, M. S.
    BMJ Case Reports, vol. 2013, bcr2013200257
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]
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