PhD, AFHEA
Advanced Research Fellow
- 51cg
-
- Email Address
- c.s.whyte@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437897
- Office Address
Lab 1.33 Office 3.47:6
Institute of Medical Sciences
- School/Department
- School of Medicine, Medical Sciences and Nutrition


Biography
I am an Advanced Research Fellow at the Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Science. I obtained my PhD in Medical Sciences at Rowett Research Institute of Nutrition and Health through the 51cg. My research to date has focused on cellular regulation of fibrinolysis with a particular interest in the role of platelets in directing this process. I have also investigated fibrinolytic dysregulation in disease situations including COVID-19, DVT and stroke. I was the first recipient of Friends of Anchor's Transition to Independence Fellowship and I am currently funded by the British Heart Foundation to investigate dysregulated fibrinolysis in cancer associated thrombosis.
Qualifications
- PhD Medical Sciences2009 - 51cg
Memberships and Affiliations
- Internal Memberships
-
University Research Committee - ECR Representative
Nvision Researcher Development Network Committee
Postdoctoral Research Committee - Institute of Medical Sciences Representative
School of Medicine, Medical Sciences & Nutrition Health and Safety Committee - ECR Representative
- External Memberships
-
British Society for Haemostasis and Thrombosis Committee
Vice-Chair - International Society for Fibrinolysis and Proteolysis
Membership Committee - International Society on Thrombosis and Haemostasis
Latest Publications
ADAMTS13 fusion constructs with dual activity against VWF: a novel strategy for iTTP
Journal of Thrombosis and HaemostasisContributions to Journals: Articles- [ONLINE] DOI:
Plg-R KT facilitates plasminogen incorporation and restrains thrombus growth under arterial shear in mice
Molecular MedicineContributions to Journals: Articles- [ONLINE] DOI:
Colchicine acutely reduces liver-secreted inflammatory and metabolic proteins in blood
European Journal of Pharmacology, vol. 1020, 178725Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Cancer-Associated Thrombosis (CAT); mechanisms and treatment options
Thrombosis Journal, vol. 23, no. 1, 116Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
Research and Practice in Thrombosis and Haemostasis, vol. 9, no. 5, 102929Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Prizes and Awards
D. Collen Young Investigator Award runner up 2023
D. Collen Young Investigator Award runner up 2018
- Research
-
Supervision
Previous PhD students (second supervisor):
Dr Joanne Mitchell
Dr Gael Morrow
Dr Fahad Alshehri
Dr Steven Humphreys
Dr Anuj Narwal
Supervisees
- MR KIERAN POCKNELL
- DR TAREQ AL TARAWNI
- MR JACK PARTRIDGE
Funding and Grants
Current Funding as Principal Investigator:
Defining the role of fibrinolytic dysregulation in breast cancer associated thrombosis. The British Heart Foundation. Co-Investigators Prof Valerie Speirs and Prof Nicola Mutch.
Current Funding as Co-Investigator:
Bleeding after childbirth – exploring abnormal blood clotting and how to treat it. Chief Scientist Office. PI: Prof Nicola J Mutch. Co-I Dr Mairead Black, Dr Lucy De Lloyd, Prof Peter Collins, Dr Sarah Bell.
Arterial Thrombosis In Type II Diabetes: A Role For Impaired Fibrinolysis. Medical Research Scotland. PI: Prof Nicola J Mutch. Co-I Dr Dana Huskens.
Targeting impaired Fibrinolysis in Acute Coronary Syndrome: A Path to Better Treatment. Heart Research UK. PI: Prof Nicola Mutch. Co-I Prof Diana Gorog.
S100A8/A9 as a novel regulator of fibrinolysis in thromboinflammation. The British Heart Foundation. PI: Prof Nicola J Mutch, Co-Is Dr Julie Rayes and Dr Alexander Brill.
The role of vascular endothelial cells in dictating local fibrinolytic potential and thrombo-inflammatory complications. Medical Research Scotland. PI: Prof Nicola Mutch.
- Teaching
- Publications
-
Page 2 of 4 Results 11 to 20 of 34
All tangled up: interactions of the fibrinolytic and innate immune systems
Frontiers in Medicine, vol. 10, 1212201Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Editorial: Women in Thrombosis
Frontiers in cardiovascular medicine, vol. 10, 1159938Contributions to Journals: Editorials- [ONLINE] DOI:
- [OPEN ACCESS]
Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi
Contributions to Journals: Short Survey- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
“Going with the flow” in modeling fibrinolysis
Frontiers in cardiovascular medicine, vol. 9, 1054541Contributions to Journals: Review articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
COVID-19 disease is associated with a hypofibrinolytic state driven by elevated plasminogen activator inhibitor-1 and its cofactor vitronectin.
International Society of Thrombosis and Haemostasis, PB0605Contributions to Journals: Abstracts- [ONLINE] DOI:
The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1
Journal of Thrombosis and Haemostasis, vol. 20, no. 10, pp. 2394-2406Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Plasminogen Activator Inhibitor-1 and its cofactor vitronectin induce a hypofibrinolytic state in COVID-19 disease which correlates with disease severity.
British Society of Thrombosis and HaemostasisContributions to Conferences: Abstracts- [ONLINE]
- [ONLINE]
A serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease
Frontiers in cardiovascular medicine, vol. 8, 653655Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
International Journal of Molecular Sciences, vol. 22, no. 6, 3055Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
uPA-mediated plasminogen activation is enhanced by polyphosphate
Haematologica, vol. 106, no. 2, pp. 522-531Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]