51cg

People

Dr Dawn Thompson

Dr Dawn Thompson
Dr Dawn Thompson
Dr Dawn Thompson

BSc, PhD

Lecturer

51cg
Email Address
dthompson@abdn.ac.uk
Office Address

office 6.15/lab 2.48

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences,

Foresterhill, Aberdeen

ext: office:7513

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I received my B.Sc Hons in Pharmacology from the 51cg before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity.  I returned to the 51cg and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.     

Research

Research Overview

My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.  

Research Areas

Biomedical Sciences

View Research Area

Research Specialisms

  • Pharmacology
  • Neuroscience
  • Cell Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.

Publications

Page 1 of 4 Results 1 to 10 of 35

  • Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

    Atkinson, S. J., Negoita, F., Ioi, Y., Ritchie, W. V., Thompson, K., Gardner, M., Ashdown, P. T., Hellberg, K., Takahara, T., Sakamoto, K., Thompson, D., Hislop, J. N., Hatakeyama, R.
    The Biochemical journal, vol. 483, no. 10, pp. 1817-1834
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Investigation into ligand selectivity and bias at the formyl peptide receptor family

    Jack, C. E., Thomson, C. M., Dall’Angelo, S., Thompson, D., Hislop, J. N.
    Journal of Pharmacology and Experimental Therapeutics, vol. 393, no. 1, 103764
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents

    He, M., Thomson, C., Thompson, D., Kuodis, V., Smith, T., Dall'Angelo, S., O'hagan, D.
    ChemBioChem, vol. 26, no. 22, e202500384
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Identification of a regulatory sequence within the third intracellular loop that governs β-arrestin binding to the muscarinic M5 receptor

    Steinmüller, S., Thompson, K., Alenfelder, J., Drube, J., Hoffmann, C., Kostenis, E., Thompson, D., Hislop, J.
    Cellular Signalling, vol. 135, 112004
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., McIlroy, G. D., Rochford, J., Mody, N.
    Experimental Physiology, vol. 110, no. 8, pp. 1071-1086
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

    Leeson-Payne, A., Iyinikkel, J., Malcolm, C., Lam, B. Y. H., Sommer, N., Dowsett, G. K. C., Blanco Martinez de Morentin, P., Thompson, D., MacKenzie, A., Chianese, R., Kentistou, K. A., Gardner, E. J., Perry, J. R., Grassmann, F., Speakman, J., Rochford, J., Yeo, G. S. H., Murray, F., Heisler, L.
    Cell Metabolism, vol. 36, no. 5, pp. 1076-1087
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A refined method of adult tissue resident stem cell derived primary human hepatic organoid cultures

    Clegg, F., Thompson, D., McLean, M. H., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • FGF21 sensitivity in hepatocellular carcinoma could be impaired through reduction in FGFR1 and KLB expression

    Clegg, F., McLean, M. H., Thompson, D., Murray, G., Delibegovic, M.
    Contributions to Journals: Conference Articles
    • [ONLINE] DOI:

  • Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice

    Mahmood, S., Morrice, N., Thompson, D., Milanizadeh, S., Wilson, S., Whitfield, P. D., Mcilroy, G. D., Rochford, J. J., Mody, N.
    Working Papers: Preprint Papers
    • [ONLINE] DOI:

  • P125: Development and Evaluation of a Novel Antibody to Human FGF21

    Clegg, F., Addawiyah Imawana, R., Alnabulsi, A., McLean, M. H., Thompson, D., Delibegovic, M., Murray, G.
    Journal of Pathology, vol. 261, no. S1, pp. S63
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:
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