51cg

People

Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

51cg
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the 51cg, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - 51cg 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available  on using instrumental variables in a surgery trial to address non-compliance. Collaborators were  (Oxford), (Lancaster), and (Manchester). 

Research on making trials more efficient, collaborating with . 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • The split-plot design was useful for evaluating complex, multi-level interventions but there is need for improvement in its design and report

    Goulão, B., MacLennan, G., Ramsay, C.
    Journal of Clinical Epidemiology, vol. 96, pp. 120-125
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol

    Gillies, K., Bower, P., Elliott, J., MacLennan, G., Newlands, R. S. N., Ogden, M., Treweek, S. P., Wells, M., Witham, M. D., Young, B., Francis, J. J.
    Trials, vol. 19, 197
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • How to resolve discrepancies when findings from randomized controlled trials and meta-analyses disagree?

    Sylvester, R., Canfield, S. E., Lam, T., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernández, V., Plass, K., Van Poppel, H., N'Dow, J.
    33rd Annual EAU Congress 2018
    Contributions to Conferences: Posters
    • [ONLINE]

  • Male synthetic sling versus artificial urinary sphincter trial for men with urodynamic stress incontinence after prostate surgery (MASTER): Study protocol for a randomised controlled trial

    Constable, L., Cotterill, N., Cooper, D., Glazener, C., Drake, M. J., Forrest, M., Harding, C., Kilonzo, M., MacLennan, G., McCormack, K., McDonald, A., Mundy, A., Norrie, J., Pickard, R., Ramsay, C., Smith, R., Wileman, S., Abrams, P., The MASTER Study Group
    Trials, vol. 19, pp. 1-17
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis

    Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.
    BMJ, vol. 359, j4849
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Bayesian clinical trial designs: Another option for trauma trials?

    Jansen, J. O., Pallmann, P., MacLennan, G., Campbell, M. K., UK-REBOA Trial Investigators
    The journal of trauma and acute care surgery, vol. 83, no. 4, pp. 736-741
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • THISTLE: trial of hands-on Interprofessional simulation training for local emergencies: a research protocol for a stepped-wedge clustered randomised controlled trial

    Lenguerrand, E., Winter, C., Innes, K., MacLennan, G., Siassakos, D., Lynch, P., Cameron, A., Crofts, J., McDonald, A., McCormack, K., Forrest, M., Norrie, J., Bhattacharya, S., Draycott, T., Thistle group
    BMC Pregnancy and Childbirth, vol. 17, 294
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The SIMS trial: adjustable anchored single-incision mini-slings versus standard tension-free midurethral slings in the surgical management of female stress urinary incontinence. A study protocol for a pragmatic, multicentre, non-inferiority randomised controlled trial

    Abdel-Fattah, M., Maclennan, G., Kilonzo, M., Assassa, R. P., McCormack, K., Davidson, T., McDonald, A., N'Dow, J., Wardle, J., Norrie, J.
    BMJ Open, vol. 7, no. 8, pp. 1-18
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget's Disease of Bone: The PRISM-EZ Study

    Tan, A., Goodman, K., Walker, A., Hudson, J., MacLennan, G. S., Selby, P. L., Fraser, W. D., Ralston, S. H., PRISM-EZ Trial Group
    Journal of Bone and Mineral Research, vol. 32, no. 6, pp. 1165-1173
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Conflict of Evidence: Resolving Discrepancies When Findings from Randomized Controlled Trials and Meta-analyses Disagree

    Sylvester, R. J., Canfield, S. E., Lam, T. B. L., Marconi, L., MacLennan, S., Yuan, Y., MacLennan, G., Norrie, J., Omar, M. I., Bruins, H. M., Hernandez, V., Plass, K., Van Poppel, H., N'Dow, J.
    European Urology, vol. 71, no. 5, pp. 811-819
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The BJUI's clinical trials initiative

    Davis, J. W., MacLennan, G.
    BJU International, vol. 119, no. 4, pp. 503
    Contributions to Journals: Editorials
    • [ONLINE] DOI:
    • [ONLINE]

  • Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT)

    Glazener, C. M. A., Breeman, S., Elders, A., Hemming, C., Cooper, K. G., Freeman, R. M., Smith, A. R. B., Reid, F., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J., PROSPECT study group
    The Lancet, vol. 389, no. 10067, pp. 381–392
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

    Cook, J. A., Beard, D. J., Cook, J. R., MacLennan, G. S.
    Pilot & Feasibility Studies, vol. 2, 73
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical effectiveness and cost-effectiveness of surgical options for the management of anterior and/or posterior vaginal wall prolapse: two randomised controlled trials within a comprehensive cohort study - results from the PROSPECT Study

    Glazener, C., Breeman, S., Elders, A., Hemming, C., Cooper, K., Freeman, R., Smith, A., Hagen, S., Montgomery, I., Kilonzo, M., Boyers, D., McDonald, A., McPherson, G., MacLennan, G., Norrie, J.
    Health Technology Assessment, vol. 20, no. 95, pp. 1-452
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?

    Fielding, S., Ogbuagu, A., Sivasubramaniam, S., MacLennan, G., Ramsay, C. R.
    Quality of Life Research, vol. 25, no. 12, pp. 2977-2983
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The eEffectiveness and cost-effectiveness of Surgical Treatments for womEn with stRess urinary incontinence:: an evidence synthesis (ESTER)

    Brazzelli, M., Craig, D., Imamura, M., Wallace, S., MacLennan, G., Hudson, J., Saraswat, L., Omar, M. I., Montgomery, I.
    Contributions to Journals: Registered Reports
    • [ONLINE]

  • Breast pumps as an incentive for breastfeeding: a mixed methods study of acceptability

    Crossland, N., Thomson, G., Morgan, H., MacLennan, G., Campbell, M., Dykes, F., Hoddinott, P.
    Maternal and Child Nutrition, vol. 12, no. 4, pp. 726-739
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial

    Pyle, M., Norrie, J., Schwannauer, M., Kingdon, D., Gumley, A., Turkington, D., Byrne, R., Syrett, S., MacLennan, G., Dudley, R., McLeod, H. J., Griffiths, H., Bowe, S., Barnes, T. R. E., French, P., Hutton, P., Davies, L., Morrison, A. P.
    BMC Psychiatry, vol. 16, pp. 1-12
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A protocol for a systematic review of non-randomised evaluations of strategies to improve participant recruitment to randomised controlled trials

    Gardner, H. R., Fraser, C., MacLennan, G., Treweek, S.
    Systematic reviews , vol. 5, 131
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review

    Cruickshank, M., Henderson, L., MacLennan, G., Fraser, C., Campbell, M., Blackwood, B., Gordon, A., Brazzelli, M.
    Health Technology Assessment, vol. 20, no. 25, pp. 0-120
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Behavioural recovery after treatment for varicose veins

    Cotton, S. C., MacLennan, G., Brittenden, J., Prior, M., Francis, J.
    British Journal of Surgery, vol. 103, no. 4, pp. 374-381
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The ethics of future trials: qualitative analysis of physicians' decision making

    Webster, F., Weijer, C., Todd, L., Grimshaw, J. M., Marshall, A. P., Cook, D., MacLennan, G., Cuthbertson, B. H., Francis, J. J., SuDDICU International Study Group
    Trials, vol. 17, pp. 1-8
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Mindfulness-Based Stress Reduction for Veterans With PTSD

    Goulao, B., MacLennan, G. S.
    JAMA, vol. 315, no. 1, pp. 87-88
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Kurzdarstellung aktueller publikationen: Begünstigt eine muskelrelaxierende therapie den uretersteinabgang?

    Pickard, R., Starr, K., MacLennan, G., Lam, T., Thomas, R., Burr, J., McPherson, G., McDonald, A., Anson, K., N'Dow, J., Burgess, N., Clark, T., Kilonzo, M., Gillies, K., Shearer, K., Boachie, C., Cameron, S., Norrie, J., McClinton, S.
    Nieren- und Hochdruckkrankheiten, vol. 45, no. 1, pp. 38
    Contributions to Journals: Articles
    • [ONLINE]

  • Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial): study protocol for a randomised controlled trial

    Stephenson, R., Carnell, S., Johnson, N., Brown, R., Wilkinson, J., Mundy, A., Payne, S., Watkin, N., N'Dow, J., Sinclair, A., Rees, R., Barclay, S., Cook, J. A., Goulao, B., MacLennan, G., McPherson, G., Jackson, M., Rapley, T., Shen, J., Vale, L., Norrie, J., McColl, E., Pickard, R.
    Trials, vol. 16, 600
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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