51cg

People

Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Head of Trial Management

51cg
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address
Aberdeen Centre for Evaluation, Third floor, Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the 51cg with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the 51cg.

I am Head of Trial Management/Senior Trial Manager within CHaRT supporting the portfolio of trials.      

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including ALLEGRO, BICS, TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - 51cg 
  • MLitt by research 
    1994 - 51cg 
  • PhD Public Health 
    2008 - 51cg 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

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Nutrition and Health

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Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course ().

 

Publications

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  • Psychosocial morbidity in women with abnormal cervical cytology managed by cytological surveillance or initial colposcopy: longitudinal analysis from the TOMBOLA randomised trial

    Fielding, S., Rothnie, K., Gray, N. M., Little, J., Cruickshank, M., Neal, K., Walker, L., Whynes, D., Cotton, S., Sharp, L.
    Psycho-Oncology, vol. 26, no. 4, pp. 476–483
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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  • An Open-Label Investigation of the Pharmacokinetics and Tolerability of Oral Cysteamine in Adults with Cystic Fibrosis

    Devereux, G., Steele, S., Griffiths, K., Devlin, E., Fraser-Pitt, D., Cotton, S., Norrie, J., Chrystyn, H., O'Neil, D.
    Clinical Drug Investigation, vol. 36, no. 8, pp. 605-612
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • HPV immunisation and cervical screening - confirmation of changed performance of cytology as a screening test in immunised women: a retrospective population based cohort study

    Palmer, T. J., McFadden, M., Pollock, K. G. J., Kavanagh, K., Cuschieri, K., Cruickshank, M., Cotton, S., Nicoll, S., Robertson, C.
    British Journal of Cancer, vol. 114, no. 5, pp. 582-589
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Behavioural recovery after treatment for varicose veins

    Cotton, S. C., MacLennan, G., Brittenden, J., Prior, M., Francis, J.
    British Journal of Surgery, vol. 103, no. 4, pp. 374-381
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Impact of post-colposcopy management on women's long-term worries: results from the UK population-based TOMBOLA trial

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N., Smart, L., Whynes, D., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Family Planning and Reproductive Health Care, vol. 42, no. 1, pp. 43-51
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Decision aids for people considering taking part in clinical trials

    Gillies, K., Cotton, S. C., Brehaut, J. C., Politi, M. C., Skea, Z.
    Cochrane Database of Systematic Reviews, no. 11, CD009736
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long-term Worries after Colposcopy: Which Women Are at Increased Risk?

    Sharp, L., Cotton, S. C., Cruickshank, M. E., Gray, N. M., Neal, K., Rothnie, K., Thornton, A. J., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Women's Health Issues, vol. 25, no. 5, pp. 517-527
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • SMS text pre-notification and delivery of reminder e-mails to increase response rates to postal questionnaires in the SUSPEND trial: a factorial design, randomised controlled trial

    Starr, K., McPherson, G., Forrest, M., Cotton, S. C.
    Trials, vol. 16, 295
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

    Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J. A. F., Lee, A. J., McCormack, K., McPherson, G., Morice, A., Norrie, J., Sullivan, A., Wilson, A., Price, D.
    Trials, vol. 16, 267
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform

    Treweek, S., Altman, D. G., Bower, P., Campbell, M., Chalmers, I., Cotton, S., Craig, P., Crosby, D., Davidson, P., Devane, D., Duley, L., Dunn, J., Elbourne, D., Farrell, B., Gamble, C., Gillies, K., Hood, K., Lang, T., Littleford, R., Loudon, K., McDonald, A., McPherson, G., Nelson, A., Norrie, J., Ramsay, C., Sandercock, P., Shanahan, D. R., Summerskill, W., Sydes, M., Williamson, P., Clarke, M.
    Trials, vol. 16, 261
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A normal colposcopy examination fails to provide psychological reassurance for women who have had low-grade abnormal cervical cytology

    Cotton, S. C., Sharp, L., Little, J., Gray, N. M., Walker, L. G., Whynes, D. K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Cytopathology, vol. 26, no. 3, pp. 178-187
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial

    Brittenden, J., Cotton, S. C., Elders, A., Tassie, E., Scotland, G., Ramsay, C. R., Norrie, J., Burr, J., Francis, J., Wileman, S., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., MacLennan, G., Prior, M., Bolsover, D., Campbell, M. K.
    Health Technology Assessment, vol. 19, no. 27, pp. 1-342
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Management of women with low grade cytology: how reassuring is a normal colposcopy examination?

    Cruickshank, M. E., Cotton, S. C., Sharp, L., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 122, no. 3, pp. 380-386
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Normative data for the Hospital Anxiety and Depression Scale

    Breeman, S., Cotton, S., Fielding, S., Jones, G. T.
    Quality of Life Research, vol. 24, no. 2, pp. 391-398
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM)

    Rothnie, K., Cotton, S. C., Fielding, S., Gray, N. M., Little, J., Cruickshank, M. E., Walker, L. G., Avis, M., Sharp, L.
    Health and Quality of Life Outcomes, vol. 12, 154
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cost-effectiveness of ultrasound-guided foam sclerotherapy, endovenous laser ablation or surgery as treatment for primary varicose veins from the randomized CLASS trial

    Tassie, E., Scotland, G., Brittenden, J., Cotton, S. C., Elders, A., Campbell, M. K., Campbell, B., Gough, M., Burr, J. M., Ramsay, C. R., CLASS Study Team
    British Journal of Surgery, vol. 101, no. 12, pp. 1532-1540
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A randomized trial comparing treatments for varicose veins

    Brittenden, J., Cotton, S. C., Elders, A., Ramsay, C. R., Norrie, J., Burr, J., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Francis, J., Tassie, E., Scotland, G., Wileman, S., Campbell, M. K.
    The New England Journal of Medicine, vol. 371, no. 13, pp. 1218-1227
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

    Siddiqi, N., Neil, C., Bruce, M., Maclennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J. C., Frenneaux, M., NIAMI investigators
    European Heart Journal, vol. 35, no. 19, pp. 1255-1262
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance

    Sharp, L., Cotton, S., Cruickshank, M., Gray, N. M., Harrild, K., Smart, L., Walker, L. G., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Lower Genital Tract Disease, vol. 18, no. 2, pp. 142-150
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation

    Gillies, K., Huang, W., Skea, Z., Brehaut, J., Cotton, S.
    Trials, vol. 15, 62
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.
    Circulation, vol. 128, no. 24, pp. 2705
    Contributions to Journals: Abstracts

  • Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy

    Whynes, D. K., Sharp, L., Cotton, S. C., Cruickshank, M., Gray, N. M., Little, J., Waugh, N.
    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

    Grant, A. M., Boachie, C., Cotton, S. C., Faria, R., Bojke, L., Epstein, D. M., Ramsay, C. R., Corbacho, B., Sculpher, M., Krukowski, Z. H., Heading, R. C., Campbell, M. K.
    Health Technology Assessment, vol. 17, no. 22, pp. 1-166
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.
    Journal of translational medicine, vol. 11, 116
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)

    Grant, A. M., Cotton, S. C., Boachie, C., Ramsay, C. R., Krukowski, Z. H., Heading, R. C., Campbell, M. K., REFLUX Trial Group
    BMJ, vol. 346, f1908
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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