51cg

People

Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Head of Trial Management

51cg
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address
Aberdeen Centre for Evaluation, Third floor, Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the 51cg with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the 51cg.

I am Head of Trial Management/Senior Trial Manager within CHaRT supporting the portfolio of trials.      

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including ALLEGRO, BICS, TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - 51cg 
  • MLitt by research 
    1994 - 51cg 
  • PhD Public Health 
    2008 - 51cg 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

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Nutrition and Health

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Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course ().

 

Publications

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  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Abdel-Fattah, M., Johnson, D., Constable, L., Cotton, S., MacLennan, G., Norrie, J., Omar, M. I., MacLennan, S.
    The International Continence Society
    Contributions to Conferences: Posters
    • [ONLINE]
    • [ONLINE]

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    RCOG World Congress 2024, MTeP-42
    Contributions to Journals: Abstracts
    • [ONLINE]
    • [ONLINE] DOI:

  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    The International Continence Society, 101602
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Abdel-Fattah, M., Tripathee, S., Johnson, D., Constable, L., Cotton, S., Omar, M. I., MacLennan, S., Cooper, D., Norrie, J., MacLennan, G.
    RCOG World Congress 2024, pp. 171
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:
    • [ONLINE]

  • The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT

    Jansen, J. O., Hudson, J., Kennedy, C., Cochran, C., Maclennan, G., Gillies, K., Lendrum, R., Sadek, S., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Cotton, S., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., UK-REBOA Study Group
    Health Technology Assessment, vol. 28, no. 54
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Direct and indirect costs of paediatric asthma in the UK: a cost analysis

    Kennedy, C., Scotland, G., Cotton, S., Turner, S.
    Archives of Disease in Childhood, vol. 109, no. 9, pp. 724-729
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial

    Hoddinott, P., O'Dolan, C., Macaulay, L., Dombrowski, S. U., Swingler, J., Cotton, S., Avenell, A., Getaneh, A. M., Gray, C., Hunt, K., Kee, F., MacLean, A., McKinley, M., Torrens, C., Turner, K., van der Pol, M., MacLennan, G.
    JAMA, vol. 332, no. 1, pp. 31-40
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT

    Innes, K., Ahmed, I., Hudson, J., Hernández, R. A., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    Health Technology Assessment, vol. 28, no. 26, pp. 1-151
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The Bisoprolol in COPD Study (BICS): A UK Randomized Controlled Trial of Bisoprolol in People With COPD at Risk of Exacerbation

    Lipworth, B., Devereux, G., Cotton, S., Nath, M., The Bisoprolol in COPD Study (BICS) Trial Group
    ATS 2024, A6612
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial

    Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A. J., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J., Wilson, A., Wu, O., Lipworth, B. J.
    JAMA, vol. 332, no. 6, pp. 462-470
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]

  • PUrE RCT 1: Clinical and cost-effectiveness of flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones ≤10 mm

    Wiseman, O., Smith, R., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
    39th Annual EAU Congress, pp. S529
    Contributions to Journals: Abstracts
    • [ONLINE]
    • [ONLINE] DOI:

  • PUrE RCT 2: Clinical and cost-effectiveness of FURS and percutaneous nephrolithotomy for lower pole stones 10-25mm

    Smith, R., Wiseman, O., Starr, K., Aucott, L., Hernández, R., Thomas, R., Maclennan, S., Clark, T., Maclennan, G., Mcrae, D., Bell, V., Cotton, S., Gall, Z., Turney, B., Mcclinton, S.
    39th Annual EAU Congress, pp. S537
    Contributions to Journals: Abstracts
    • [ONLINE]
    • [ONLINE] DOI:

  • Exploring Opinions and Concerns about the Human Papillomavirus Vaccine on a United Kingdom Online Discussion Forum

    Klejnotowska, A., Skea, Z., Cotton, S., Cruickshank, M.
    Journal of Colposcopy and Lower Genital Tract Pathology, vol. 1, no. 3, pp. 117-123
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial

    Ahmed, I., Hudson, J., Innes, K., Hernández, R., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    BMJ, vol. 383, e075383
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

    Jansen, J. O., Hudson, J., Cochran, C., MacLennan, G., Lendrum, R., Sadek, S., Gillies, K., Cotton, S., Kennedy, C., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., Aylwin, C., Bew, D., Brooks, A., Chinery, J., Cowlam, T., Frith, D., George, A., Hudson, A., Johnstone, P., Mahmood, A., Novak, A., O'Meara, M., Reid, S., Sattout, A., Smith, C., Stansfield, T., Thompson, J., UK-REBOA Study Group
    JAMA, vol. 330, no. 19, pp. 1862-1871
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • A qualitative process evaluation within a clinical trial that used healthcare technologies for children with asthma: insights and implications

    Lawrie, L., Turner, S., Cotton, S., Wood, J., Morgan, H.
    PloS ONE, vol. 18, no. 1, 0280086
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Randomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study

    Abdel-fattah, M., Johnson, D., Constable, L., Thomas, R., Cotton, S., Tripathee, S., Cooper, D., Boran, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., MacLennan, S., Murchie, P., Myint, P., N’Dow, J., Norrie, J., Omar, M. I., Paterson, C., Scotland, G., Thiruchelvam, N., MacLennan, G.
    Trials, vol. 23, no. 1, 630
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • An interview study within a clinical trial that used healthcare technologies for children with asthma – insights and implications

    Lawrie, L., Turner, S., Cotton, S., Wood, J., Morgan, H.
    ICTMC 2022, pp. 370
    Contributions to Conferences: Abstracts
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Trial Forge Guidance 3: Randomised trials and how to recruit and retain individuals from ethnic minority groups– practical guidance to support better practice

    Dawson, S., Banister, K., Biggs, K., Cotton, S., Devane, D., Gardner, H., Gillies, K., Gopalakrishnan, G., Isaacs, T., Khunti, K., Nichol, A., Parker, A., Russell, A. M., Shepherd, V., Shiely, F., Shorter, G. W., Starling, B., Williams, H., Willis, A., Witham, M. D., Treweek, S.
    Trials, vol. 23, no. 1, 672
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

    Macaulay, L., O’Dolan, C., Avenell, A., Carroll, P., Cotton, S., Dombrowski, S., Elders, A., Goulao, B., Gray, C., Harris, F. M., Hunt, K., Kee, F., MacLennan, G., McDonald, M. D., McKinley, M., Skinner, R., Torrens, C., Tod, M., Turner, K., van der Pol, M., Hoddinott, P.
    Trials, vol. 23, no. 1, 582
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongste, J. C., Pijnenburg, M. W., Thomas, M., Price, D.
    The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Treatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT

    Turner, S., Cotton, S., Wood, J., Bell, V., Raja, E. A., Scott, N., Morgan, H., Lawrie, L., Emele, D., Kennedy, C., Scotland, G., Fielding, S., MacLennan, G., Norrie, J., Forrest, M., Gaillard, E. A., de Jongeste, J., Pijnenburg, M. W., Thomas, M., Price, D.
    Efficacy and Mechanism Evaluation, vol. 9, no. 4
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • ScotCap - A large observational cohort study

    MacLeod, C., Hudson, J., Brogan, M., Cotton, S., Treweek, S., MacLennan, G., Watson, A. J. M.
    Colorectal Disease, vol. 24, no. 4, pp. 411-421
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

    Cotton, S., Devereux, G., Abbas, H., Briggs, A. H., Campbell, K., Chaudhuri, R., Choudhury, G., Dawson, D., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lang, C. C., Lee, A., MacLennan, G., MacNee, W., McCormack, K., McMeekin, N., Mills, N. L., Morice, A., Norrie, J., Petrie, L., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J. A., Wilson, A., Lipworth, B. J.
    Trials, vol. 23, no. 1, 307
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The relative importance of information items and preferred mode of delivery when disseminating results from trials to participants: a mixed methods study

    Wood, J., Cotton, S., Gillies, K.
    Health Expectations, vol. 25, no. 1, pp. 419-429
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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