Dr Wenbo Zhan | The 51cg

Dr Wenbo Zhan

Lecturer

51cg

Email Address

w.zhan@abdn.ac.uk

Office Address

R353, Fraser Noble Building

School of Engineering

King's College

51cg

Aberdeen AB24 3UE, UK

School/Department

School of Engineering

Biography

Wenbo Zhan is a Lecturer in Biomedical Engineering in the School of Engineering. He received his undergraduate degrees from Xi’an Jiaotong University in 2008 and a master degree from Harbin Institute of Technology in 2010. He graduated from Imperial College London with his PhD degree in 2014 and then worked as a project consultant at Imperial College London and a postdoctoral research fellow at the National University of Singapore until 2016. Prior to joining the 51cg in 2019, he was a research associate at Imperial College London.

Qualifications

PhD Chemical Engineering
2014 - Imperial College London
MSc Thermal Energy and Power Engineering
2010 - Harbin Institute of Technology
BEng Thermal Energy and Power Engineering
2008 - Xi'an Jiaotong University
BEc Finance
2008 - Xi'an Jiaotong Univerisity

External Memberships

Editorial Board member of , 07/2026-present
Editorial Advisory Board member of , 12/2022-present
Member of European Society of Biomechanics

Research

Research Overview

Dr Zhan's research centres on biomedical engineering. He develops multiphysics and AI-enabled models to study fluid and tissue mechanics and transport processes in biological and physiological systems, with an emphasis on revealing the biophysical mechanisms underlying disease progression and on developing personalised medicine and precision therapy.

Mass transfer in biological systems, focusing on advanced drug delivery systems and modalities
Biofluid mechanics, including haemodynamics and fluid transport in tissues
Tissue mechanics, with applications to soft biological tissues and disease modelling
Image-based modelling, integrating medical imaging with physics-based modelling approaches

Funding and Grants

M2M-Brain: Mechanics to medicine - biphasic biomechanics and fluid transport in the brain, European Society of Biomechanics, Co-I (01/08/2026-31/07/2028)
Injectable thermosensitive hydrogel for controlled drug release targeting resected glioblastoma, The Royal Society, PI (01/10/2024-30/09/2026)
HyWay: Hydrogen production from waste, European Union & EPSRC, Co-I (15/04/2024-14/04/2028)
Evaluation and optimisation of thermosensitive hydrogel for controllable drug delivery against brain tumour, The Royal Society of Edinburgh, PI (01/02/2023-30/09/2023)
Image-based modelling and optimisation of convection-enhanced delivery for combination therapy against heterogeneous human brain tumour, The Royal Society, PI (12/08/2022-11/08/2024)
Gender differences in sex hormone transport in abdominal aortic aneurysm, The Royal Society, PI (31/03/2022-30/03/2024)
Optimisation of infusion catheter posture for improving convection-enhanced drug delivery to brain cancer, Children with Cancer UK – Children's Brain Tumour Drug Delivery Consortium, PI (01/03/2022-30/09/2022)
Porescale modelling of drug transport in brain tumours, 51cg School of Engineering PhD studentship, PI (01/09/2021-31/08/2024)
Nanoparticle-embedded membranes for long-term bioactive SARS-CoV2 prevention, Grampian University Hospitals NHS Trust, Co-I (01/04/2021-31/03/2023)
Multifunctional liquid crystals stabilised by hydrogen-bonding and their integration in new devices for energy harvesting, conversion and storage, The Royal Society of Edinburgh, Co-I (23/10/2020-30/12/2021)

Teaching

Teaching Responsibilities

Module coordinator

EG20H7 - Fluid Mechanics 1
EG30H3 - Fluid Mechanics 2
EG555L - Modelling of Biological Systems

Module contributor

EG55M1/6E - Finite Element Methods

Previously delivered modules

EG504Q - Introduction to Engineering for Life Scientists
EG555J - Research Methods for Bioengineers
EG4578 - BEng Group Design Project (Chemical Engineering)
EG5565 - MEng Group Design Project (Chemical & Mechanical Engineering)

Publications

Update

51cg

Biography

Qualifications

External Memberships

Research Overview

Funding and Grants

Teaching Responsibilities

Module coordinator

Module contributor

Previously delivered modules

Image-based modelling of rock non-linear deformation under low stress levels

Model-based analysis of nanocarrier-mediated transdermal drug delivery with coated microneedles

Multiscale and Multiphysics Modelling of Fluid Transport in the Brain

Hydrogel-mediated delivery of drug nanocarriers in the oedematous postoperative brain

Mechanistic modelling of transdermal delivery dependence on drug properties

From images to physics-based computational models to digital twins: A framework for personalized cancer therapies

Design parameter effects on controlled drug delivery through implantable hydrogels

Image-based multiphysics modelling of thermosensitive liposome-mediated drug delivery to liver tumour under high-intensity focused ultrasound heating

Pore-scale analysis of nanoparticle diffusion in brain tumours

Infusion-based drug delivery to the brain: What’s next?

Hydrogel-mediated delivery of chemotherapeutic agents to the brain after tumour resection

Multiphysics modelling enhanced by imaging and artificial intelligence for personalised cancer nanomedicine: Foundations for clinical digital twins

Mathematical modelling of hollow microneedle-mediated transdermal drug delivery

Shear-dependent transmural oxygen transport in the multilayered wall of an axisymmetric arterial dilation model

Blood–brain mechanics: How brain tissue responds to pulsatile blood flow dynamics

A Comparative Analysis of Alpha and Beta Therapy in Prostate Cancer Using a 3D Image-Based Spatiotemporal Model

Exploring Tissue Permeability of Brain Tumours in Different Grades: Insights from Pore-scale Fluid Dynamics Analysis

Effect of infusion posture on convection-enhanced drug delivery to anisotropic tissue

A comprehensive review on modeling aspects of infusion-based drug delivery in the brain

On the Characteristics of Fluid Transport within Reconstructed Brain Tumours at Pore-Scale

Microstructure-based Modelling Reveals Macroscale Transport Property of Brain Tissues

Image-based predictive modelling frameworks for personalised drug delivery in cancer therapy

A Computational Framework for Mechanically Controlled Brain Drug Delivery

A novel regional-minima image segmentation method for fluid transport simulations in unresolved rock images

Pore-Scale Analysis of Fluid Transport in Different Grades of Brain Tumours Considering the Effect of Extracellular Matrix

Pore-Scale Modelling of Non-Linear Rock Deformation under Low Stress Ranges

Numerical simulation of transdermal delivery of drug nanocarriers using solid microneedles and medicated adhesive patch

Investigating Charged Nanoparticles Diffusion in Brain Tumour Microstructures at Pore Scale

Elucidating the Effect of Zeta Potential and Particle Size on Nanoparticle Diffusion in Brain Tumours

Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model

Decoding the effect of different tumor heterogeneities on thermosensitive liposome drug delivery during radiofrequency ablation: A novel heat and mass transfer perspective

Mathematical modelling of microneedle-mediated transdermal delivery of drug nanocarriers into skin tissue and circulatory system

Highlighting the effect of heterogeneous blood perfusion on radio-frequency ablation of human brain tumors: An image-based numerical investigation

177Lu-PSMA-617 Transport in Solid Tumors via a 3D Image-based Spatio-temporal Model

Effect of extracellular matrix on tissue hydraulic permeability of the brain tumour

A novel local-minima 3D image segmentation method for fluid flow in low-resolution porous material images

Linking fluid-axons interactions to the macroscopic fluid transport properties of the brain

Multiphysics Simulation in Drug Development and Delivery

Mathematical Optimisation of Magnetic Nanoparticle Diffusion in the Brain White Matter

In-situ vaccination using dual responsive organelle targeted nanoreactors

Pore-scale modelling of elastic properties in hydrate-bearing sediments using 4-D synchrotron radiation imaging

Convection-Enhanced Delivery of Antiangiogenic Drugs and Liposomal Cytotoxic Drugs to Heterogeneous Brain Tumor for Combination Therapy

On the microstructurally driven heterogeneous response of brain white matter to drug infusion pressure

Effects of tissue hydraulic permeability on intracerebral transport of interstitial fluid and nanoparticle-encapsulated drugs upon convection-enhanced delivery

Numerical modelling of nanoparticle-mediated drug delivery across blood-brain barrier using focused ultrasound

Effect of tissue permeability on drug transport in brain tumour after pressure-driven infusion

Role of Tissue Hydraulic Permeability in Convection-Enhanced Delivery of Nanoparticle-Encapsulated Chemotherapy Drugs to Brain Tumour

Effect of particle size and surface charge on nanoparticles diffusion in the brain white matter

Mathematical modelling of nanoparticle-mediated topical drug delivery to skin tissue

Convection Enhanced Delivery of Light Responsive Antigen Capturing Oxygen Generators for Chemo-Phototherapy Triggered Adaptive Immunity

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