51cg

The School of Biological Sciences

Dr Sharon Mitchell

In this section
Dr Sharon Mitchell
Dr Sharon Mitchell
Dr Sharon Mitchell

PhD (Aberdeen University 2002)

Advanced Research Fellow

51cg
Email Address
s.e.mitchell@abdn.ac.uk
Office Address

319, Zoology Building, Tillydrone Avenue, Aberdeen, AB24 2TZ

School/Department
School of Biological Sciences




Biography

2015-date       Advanced Research Fellow, Lab Manager Energetics Research Group

Research

Supervision

2016-2022 Megan Simpson "The impact of reproduction on physiology and oxidative stress in female C57BL/6 mice"

2016-2020 Jazmin Mendoza “Impacts of the thermic effect of food on feeding behaviour in mice: a test of the heat dissipation limits theory”

2015-2020 Emem Udoh PhD “Impacts of Calorie Restriction on Behaviour and Post-restriction Hyperphagia”

2015-2017 Heba Althubaiti “Fruit and Vegetable Intake and its Relationship with Health Parameters in Primary School Children”

Masters

2021-2022 Master of Science by Research Daniel Phillips “Bioinformatic Characterisation of Alternative Splicing in Three Different Tissues of Male C57BL/6 Mice Following Short-Term Graded Calorie Restriction"

2019-2020  MSci Daniel Phillips “Remodelling of three different tissues in the male C57BL/6 mouse during short-term graded caloric restriction is caused by tissue-specific variations in cell size and number”

2018-2019  MRes Stephanie Summers "The Impact of Short-Term Graded Calorie Restriction on Melanocortin-3 receptor (MC3R) Knockout Mice"

2013-2015 MSci  Megan Simpson “The effect of maternal age on offspring susceptibility to high fat diet induced obesity and offspring expression of hypothalamic obesity related genes”.

2011-2013 MRes Dawn Graham, “The Role of Neuropeptides and their Receptors in Response to Increased Hunger, Reduced Food Intake and Reduced Body Fat Content”.

2011-2013 MRes Nicole Culbert, “Does Hunger Neuropeptide and Energy Balance Manipulation Affect Metabolic Rate and Antioxidant Activity in C57BL/6 Mice under Caloric Restriction?”

Supervisor of a number of Erasmus Funded Internships from AgroSup, Djon, France.

Supervisees

  • MISS AMY GILMARTIN
  • MS HUIHUI MEI
Teaching

Courses

Teaching Responsibilities

Lab Skills in Biosciences (BI35F4), co-coordinator with Cath Jones

Supervisor for laboratory-based research projects for Honours students

 

Lecturer on following courses:

Comparative Physiology 2 (BI3512)

Diversity of Life 2 (BI1512)

Publications

Page 1 of 3 Results 1 to 25 of 68

  • A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction

    Phillips, D., Mitchell, S., Derous, D., Speakman, J.
    Life metabolism, vol. 5, no. 2, loaf046
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice

    Moulds, T. P., Mitchell, S. E., Yang, X., Guo, W., Chen, E., Adams, P. D., Speakman, J. R.
    Aging Cell, vol. 25, no. 1, e70342
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice

    Mitchell, S., Heib, L., Green, C. L., Derous, D., Hambly, C., Speakman, J.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 80, no. 11, glaf168
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory

    Mitchell, S. E., Simpson, M., Coulet, L., Gouedard, S., Hambly, C., Morimoto, J., Allison, D. B., Speakman, J. R.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 42, e2408682121
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake

    Smith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., Allison, D. B., Speakman, J. R., Nagy, T. R.
    GeroScience, vol. 46, pp. 4809–4826
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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  • Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.

    Osorio Mendoza, J., Mitchell, S., Hambly, C., Allison, D. B., Speakman, J.
    Appetite, vol. 200, 107421
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction

    Gutierrez, E., Mitchell, S., Hambly, C., Sayle, K. l., Von kriegsheim, A., Speakman, J. r., Britton, K.
    iScience, vol. 27, no. 6, 110059
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Turmeric shortens lifespan in houseflies

    Laurie, S., Ainslie, L., Mitchell, S., Morimoto, J.
    Frontiers in Insect Science, vol. 4, 1376011
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice

    Mitchell, S. E., Togo, J., Green, C. L., Derous, D., Hambly, C., Speakman, J. R.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 78, no. 11, pp. 1953-1963
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

    Semerciöz-Oduncuoğlu, A. S., Mitchell, S. E., Özilgen, M., Yilmaz, B., Speakman, J. R.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 37, e2300624120
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

    Krol, E., Turner, F., Derous, D., Mitchell, S. E., Martin, S., Douglas, A., Speakman, J.
    Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, pp. 171-192
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction

    Phillips, D., Mathers, H., Mitchell, S. E., Speakman, J. R.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 77, no. 10, pp. 1994-2001
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The effects of graded calorie restriction XVII: Multitissue metabolomics reveals synthesis of carnitine and NAD, and tRNA charging as key pathways

    García-Flores, L. A., Green, C. L., Mitchell, S. E., Promislow, D. E., Lusseau, D., Douglas, A., Speakman, J. R.
    Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 31, e2101977118
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

    Nychyk, O., Barton, W., Rudolf, A. M., Boscaini, S., Walsh, A., Bastiaanssen, T. F., Giblin, L., Cormican, P., Chen, L., Piotrowicz, Y., Derous, D., Fanning, ?., Yin, X., Grant, J., Melgar, S., Brennan, L., Mitchell, S. E., Cryan, J. F., Wang, J., Cotter, P. D., Speakman, J. R., Nilaweera, K. N.
    Cell Reports, vol. 35, no. 6, 109093
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

    Wu, Y., Li, B., Li, L., Mitchell, S. E., Green, C. L., D'Agostino, G., Wang, G., Wang, L., Li, M., Li, J., Niu, C., Jin, Z., Wang, A., Zheng, Y., Douglas, A., Speakman, J. R.
    Cell Metabolism, vol. 33, no. 5, pp. P888-904.E6
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

    Sun, D., Liu, F., Mitchell, S. E., Ma, H., Derous, D., Wang, Y., Han, J. J., Daniel E.L., P., Lusseau, D., Douglas, A., Speakman, J. R., Chen, L.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, pp. 858-866
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice

    Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 2, pp. 218-229
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
    • [ONLINE]
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  • GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

    Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L., Hundal, H. S.
    The FASEB Journal, vol. 33, no. 1, pp. 1299-1312
    Contributions to Journals: Articles
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  • The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice

    Green, C. L., Soltow, Q. A., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Jones, D. P., Speakman, J. R.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 1, pp. 16-26
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

    McIlroy, G., Mitchell, S. E., Han, W., Delibegovic, M., Rochford, J. J.
    Scientific Reports, vol. 8, 17863
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

    Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R., Demaria, M.
    Aging Cell, vol. 17, no. 3, e12746
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Limits to sustained energy intake XXVII: trade-offs between first and second litters in lactating mice support the ecological context hypothesis

    Vaanholt, L. M., Osei, D. A., Balduci, S., Mitchell, S. E., Hambly, C., Speakman, J. R.
    Journal of Experimental Biology, vol. 221, no. 5, jeb170902
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue

    Derous, D., Mitchell, S. E., Green, C. L., Wang, Y., Han, J. D. J., Chen, L., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
    The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 73, no. 3, pp. 279-288
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice

    Kagya-Agyemang, J. K., Vaanholt, L. M., Hambly, C., Król, E., Mitchell, S. E., Speakman, J. R.
    Journal of Experimental Biology, vol. 221, jeb180828
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Energy balance and the sphingosine-1-phosphate/ceramide axis

    Green, C., Mitchell, S., Speakman, J.
    Aging, vol. 9, no. 12, pp. 2463-2464
    Contributions to Journals: Editorials
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]
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