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Dr Ian Fleming

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Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

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Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition


Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

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  • Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

    Piras, M., Andriu, A., Testa, A., Wienecke, P., Fleming, I. N., Zanda, M.
    Synlett, vol. 28, no. 20, pp. 2769-2776
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

    Phyu, S. M., Tseng, C. T., Fleming, I. N., Smith, T. A. D.
    Scientific Reports, vol. 6, 36544
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

    Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

    Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M., Piras, M.
    Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

    Thompson, S., Fleming, I. N., O’Hagan, D.
    Organic & Biomolecular Chemistry, vol. 14, no. 11, pp. 3120-3129
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Changes in [18F]Fluoro-2-deoxy-D-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling

    Cooper, A. C., Fleming, I. N., Phyu, S. M., Smith, T. A. D.
    Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1523-1532
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

    Lamidi, O., Sani, M., Lazzari, P., Zanda, M., Fleming, I. N.
    Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1575-1583
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Imaging tumour hypoxia with Positron Emission Tomography

    Fleming, I. N., Manavaki, R., Blower, P. J., West, C., Williams, K. J., Harris, A. L., Domarkas, J., Lord, S., Baldry, C., Gilbert, F. J.
    British Journal of Cancer, vol. 112, no. 2, pp. 238-250
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

    Thompson, S., Onega, M., Ashworth, S., Fleming, I. N., Passchier, J., O'Hagan, D.
    Chemical Communications, vol. 51, no. 70, pp. 13542-13545
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

    Nortcliffe, A., Fleming, I. N., Botting, N. P., O'Hagan, D.
    Tetrahedron, vol. 70, no. 44, pp. 8343-8347
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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