51cg

Professor Claude Wischik

Professor Claude Wischik
Professor Claude Wischik
Professor Claude Wischik

Chair in Mental Health (Clin)

51cg
Email Address
c.m.wischik@abdn.ac.uk
Office Address

TauRx Therapeutics Ltd

1st Floor, Sir Moir Lockhead Building

395 King Street

Aberdeen

AB24 5RP

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

Page 1 of 12 Results 1 to 10 of 115

  • Atypical population pharmacokinetics of hydromethylthionine in patients with Alzheimer's disease explains unexpected phase 3 trial results

    van Maanen, E., Gonçalves, A., Chen, L., Fauchet, F., Cristea, S., Smith, J., Baddeley, T., Shiells, H., Hewitt, F., Schelter, B. O., Wischik, C. M.
    British Journal of Clinical Pharmacology, vol. 92, no. 8, pp. 2645-2656
    Contributions to Journals: Articles
  • Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer’s disease with hydromethylthionine mesylate using external control data

    Schelter, B. O., Shiells, H., Lo, S., Nazlee, N., Evans, E., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M., Baddeley, T., Harrington, C. R., Staff, R., Sandu, A., Hull, C., Stefanacci, R., Wischik, C. M., Alzheimer's Disease Neuroimaging Initiative
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 6, 100560
    Contributions to Journals: Articles
  • Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

    Penny, L., Arastoo, M., Lofthouse, R. A., Abdallah, A., Imoesi, P., Schwab, K., Shiells, H., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
    Alzheimer's Research & Therapy, vol. 18, no. 1, 65
    Contributions to Journals: Articles
  • Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease

    Wischik, C. M., Stefanacci, R., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M. D., Baddeley, T., Harrington, C. R., Penny, L. K., Arastoo, M., Staff, R., Sandu, A., Shiells, H., Lo, S., Nazlee, N., Evans, E., Hull, C., Schelter, B. O.
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480
    Contributions to Journals: Articles
  • Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease

    Robinson, L., Bray, J., Melis, V., Harrington, C. R., Wischik, C. M., Riedel, G.
    Behavioural Pharmacology, vol. 37, no. 1, pp. 64-69
    Contributions to Journals: Articles
  • Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

    Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
    ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138
    Contributions to Journals: Articles
  • Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

    Arastoo, M., Penny, L., Lofthouse, R. A., Hitchcock, A., Moelders, A. R., Szalma, S., Porter, A., Palliyil, S., Harrington, C., Wischik, C.
    Scientific Reports, vol. 15, 41881
    Contributions to Journals: Articles
  • A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine

    Al-Hilaly, Y. K., Rickard, J. E., Simpson, M., Storey, J. M., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 437, no. 17, 169231
    Contributions to Journals: Articles
  • Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023

    Anschuetz, A., Schwab, K., Harrington, C., Wischik, C., Riedel, G.
    Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476
    Contributions to Journals: Articles
  • Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment

    Wang, J., Wang, Z., Chen, S., Wang, R., Chen, K., Lu, J., Xin, J., Huang, Y., Wang, M., Xie, F., Cheng, W., Yen, T., Wischik, C. M., Cui, M., Zuo, C., Zhao, Q., Wang, Y., Yu, J.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563
    Contributions to Journals: Articles
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