51cg

Professor Claude Wischik

Professor Claude Wischik
Professor Claude Wischik
Professor Claude Wischik

Chair in Mental Health (Clin)

51cg
Email Address
c.m.wischik@abdn.ac.uk
Office Address

TauRx Therapeutics Ltd

1st Floor, Sir Moir Lockhead Building

395 King Street

Aberdeen

AB24 5RP

United Kingdom

School/Department
School of Medicine, Medical Sciences and Nutrition
Research

Research Overview

Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology

Publications

Page 1 of 3 Results 1 to 50 of 115

  • Atypical population pharmacokinetics of hydromethylthionine in patients with Alzheimer's disease explains unexpected phase 3 trial results

    van Maanen, E., Gonçalves, A., Chen, L., Fauchet, F., Cristea, S., Smith, J., Baddeley, T., Shiells, H., Hewitt, F., Schelter, B. O., Wischik, C. M.
    British Journal of Clinical Pharmacology, vol. 92, no. 8, pp. 2645-2656
    Contributions to Journals: Articles
  • Assessment of clinical and neuroimaging efficacy of treatment targeting tau pathology in mild cognitive impairment and mild to moderate Alzheimer’s disease with hydromethylthionine mesylate using external control data

    Schelter, B. O., Shiells, H., Lo, S., Nazlee, N., Evans, E., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M., Baddeley, T., Harrington, C. R., Staff, R., Sandu, A., Hull, C., Stefanacci, R., Wischik, C. M., Alzheimer's Disease Neuroimaging Initiative
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 6, 100560
    Contributions to Journals: Articles
  • Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

    Penny, L., Arastoo, M., Lofthouse, R. A., Abdallah, A., Imoesi, P., Schwab, K., Shiells, H., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
    Alzheimer's Research & Therapy, vol. 18, no. 1, 65
    Contributions to Journals: Articles
  • Clinical, imaging and blood biomarker outcomes in a Phase 3 clinical trial of tau aggregation inhibitor hydromethylthionine mesylate in mild cognitive impairment and mild to moderate dementia due to Alzheimer’s disease

    Wischik, C. M., Stefanacci, R., Bentham, P., Gauthier, S., Zetterberg, H., Wilcock, G. K., Froelich, L., Burns, A., MacSweeney, E., Ballard, C., Yu, J., Choon, T. S., Asvatourian, V., Muehlemann, N., Priel, J., Kook, K., Sullivan, T., Downie, D., Miller, S., Pringle, C., Storey, J. M. D., Baddeley, T., Harrington, C. R., Penny, L. K., Arastoo, M., Staff, R., Sandu, A., Shiells, H., Lo, S., Nazlee, N., Evans, E., Hull, C., Schelter, B. O.
    The Journal of Prevention of Alzheimer's Disease, vol. 13, no. 3, 100480
    Contributions to Journals: Articles
  • Effects of hydromethylthionine mesylate and rivastigmine in a pharmacological mouse model of Alzheimer's disease

    Robinson, L., Bray, J., Melis, V., Harrington, C. R., Wischik, C. M., Riedel, G.
    Behavioural Pharmacology, vol. 37, no. 1, pp. 64-69
    Contributions to Journals: Articles
  • Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

    Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
    ACS Chemical Neuroscience, vol. 17, no. 1, pp. 124-138
    Contributions to Journals: Articles
  • Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

    Arastoo, M., Penny, L., Lofthouse, R. A., Hitchcock, A., Moelders, A. R., Szalma, S., Porter, A., Palliyil, S., Harrington, C., Wischik, C.
    Scientific Reports, vol. 15, 41881
    Contributions to Journals: Articles
  • A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine

    Al-Hilaly, Y. K., Rickard, J. E., Simpson, M., Storey, J. M., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 437, no. 17, 169231
    Contributions to Journals: Articles
  • Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer’s disease: A meta-analysis 2015-2023

    Anschuetz, A., Schwab, K., Harrington, C., Wischik, C., Riedel, G.
    Journal of Alzheimer's Disease, vol. 107, no. 2, pp. 452-476
    Contributions to Journals: Articles
  • Role of 18F-florzolotau PET in diagnostic and therapeutic decision-making for cognitive impairment

    Wang, J., Wang, Z., Chen, S., Wang, R., Chen, K., Lu, J., Xin, J., Huang, Y., Wang, M., Xie, F., Cheng, W., Yen, T., Wischik, C. M., Cui, M., Zuo, C., Zhao, Q., Wang, Y., Yu, J.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 21, no. 8, e70563
    Contributions to Journals: Articles
  • FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning

    Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.
    Nuclear Medicine and Molecular Imaging, vol. 59, pp. 201-208
    Contributions to Journals: Articles
  • Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain

    Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.
    FEBS Journal, vol. 292, no. 10, pp. 2602-2623
    Contributions to Journals: Articles
  • Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies

    Oakley, S. S., Marshall, K. E., Meisl, G., Copsey, A., Maina, M. B., Milton, R., Vorley, T., Storey, J., Harrington, C., Wischik, C., Xue, W., Serpell, L. C.
    Working Papers: Preprint Papers
  • Obtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease

    Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.
    Scientific Reports, vol. 15, 1671
    Contributions to Journals: Articles
  • Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia

    Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
    Brain Research Bulletin, vol. 220, 111172
    Contributions to Journals: Articles
  • High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

    Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.
    Alzheimer's Research & Therapy, vol. 16, 209
    Contributions to Journals: Articles
  • Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine

    Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.
    Cellular Signalling, vol. 121, 111269
    Contributions to Journals: Articles
  • Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors

    Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.
    Brain Research Bulletin, vol. 212, 110955
    Contributions to Journals: Articles
  • Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

    Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.
    Translational neurodegeneration, vol. 13, 25
    Contributions to Journals: Review articles
  • LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy

    Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.
    European Journal of Pharmacology, vol. 970, 176505
    Contributions to Journals: Articles
  • Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model

    Zadrozny, M., Drapich, P., Gasiorowska-Bien, A., Niewiadomski, W., Harrington, C. R., Wischik, C. M., Riedel, G., Niewiadomska, G.
    Cells, vol. 13, no. 7, 642
    Contributions to Journals: Articles
  • Assays for the Screening and Characterization of Tau Aggregation Inhibitors

    Horsley, D., Rickard, J. E., Vorley, T., Leeper, M. F., Wischik, C. M., Harrington, C. R.
    Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)
  • Solubility of α-synuclein species in the L62 mouse model of synucleinopathy

    Schwab, K., Magbagbeolu, M., Theuring, F., Harrington, C., Wischik, C., Riedel, G.
    Scientific Reports, vol. 14, 6239
    Contributions to Journals: Articles
  • Apathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia

    Robinson, L., Dreesen, E., Mondesir, M., Harrington, C., Wischik, C., Riedel, G.
    Behavioural Brain Research, vol. 456, 114707
    Contributions to Journals: Articles
  • A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease

    Anschuetz, A., Schwab, K., Harrington, C. R., Wischik, C. M., Riedel, G.
    Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162
    Contributions to Journals: Articles
  • Significant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate

    Wischik, C. M., Schelter, B., Penny, L. K., Miller, S., Stefanacci, R., Heslegrave, A., Zetterberg, H.
    Alzheimer's Dementia, vol. 19, no. S24, e083153
    Contributions to Journals: Articles
  • Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants

    Arastoo, M., Mazanetz, M. P., Miller, S., Shiells, H., Hull, C., Robinson, K., Storey, J. M., Harrington, C. R., Wischik, C. M.
    International Journal of Molecular Sciences, vol. 24, no. 18, 13747
    Contributions to Journals: Articles
  • Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice

    Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.
    International Journal of Molecular Sciences, vol. 24, no. 13, 10810
    Contributions to Journals: Articles
  • Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis

    Zabala-Findlay, A., Penny, L. K., Lofthouse, R. A., Porter, A. J., Palliyil, S., Harrington, C. R., Wischik, C. M., Arastoo, M.
    Cells, vol. 12, no. 8, 1184
    Contributions to Journals: Review articles
  • An Additive-Free Model for Tau Self-Assembly

    Al-Hilaly, Y. K., Marshall, K. E., Lutter, L., Biasetti, L., Mengham, K., Harrington, C. R., Xue, W. F., Wischik, C. M., Serpell, L. C.
    Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188
    Contributions to Journals: Articles
  • Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

    Al-Hilaly, Y. K., Hurt, C., Rickard, J. E., Harrington, C. R., Storey, J. M., Wischik, C. M., Serpell, L. C., Siemer, A. B.
    Frontiers in Neuroscience, vol. 16, 988074
    Contributions to Journals: Articles
  • Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

    Maina, M. B., Al-Hilaly, Y. K., Oakley, S., Burra, G., Khanom, T., Biasetti, L., Mengham, K., Marshall, K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 434, no. 19, 167785
    Contributions to Journals: Articles
  • Oral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate

    Wischik, C. M., Bentham, P., Gauthier, S., Miller, S., Kook, K., Schelter, B. O.
    Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790
    Contributions to Journals: Articles
  • Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine

    Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
    Cellular Signalling, vol. 97, 110386
    Contributions to Journals: Articles
  • Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis

    Lutter, L., Al-Hilaly, Y. K., Serpell, C. J., Tuite, M. F., Wischik, C. M., Serpell, L. C., Xue, W. F.
    Journal of Molecular Biology, vol. 434, no. 7, 167466
    Contributions to Journals: Articles
  • HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

    Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.
    Biomedicines, vol. 10, no. 4, 867
    Contributions to Journals: Articles
  • Crossed cerebellar diaschisis in Alzheimer's disease

    Tripathi, S. M., Murray, A. D., Wischik, C. M., Schelter, B.
    Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427
    Contributions to Journals: Articles
  • Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine

    Kondak, C., Riedel, G., Harrington, C. R., Wischik, C. M., Klein, J.
    Journal of Neurochemistry, vol. 160, pp. 172-184
    Contributions to Journals: Articles
  • Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia

    Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.
    Brain Communications, vol. 3, no. 4, fcab241
    Contributions to Journals: Articles
  • Long-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier

    Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023
    Contributions to Journals: Articles
  • Proteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks

    Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.
    Cells, vol. 10, no. 8, 2162
    Contributions to Journals: Articles
  • Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates

    Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Cells, vol. 10, no. 3, 703
    Contributions to Journals: Articles
  • Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia

    Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.
    Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523
    Contributions to Journals: Articles
  • Adaptive neurological testing method

    Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.
    Patents: Patents
  • Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease

    Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.
    International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19
    Contributions to Journals: Articles
  • Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

    Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Frontiers in Neurology, vol. 11, 590754
    Contributions to Journals: Articles
  • Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

    Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.
    Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907
    Contributions to Journals: Articles
  • Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease

    Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.
    Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569
    Contributions to Journals: Articles
  • Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

    Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.
    Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519
    Contributions to Journals: Articles
  • Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

    Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.
    Current Alzheimer Research, vol. 17, no. 3, pp. 285-296
    Contributions to Journals: Articles
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