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Professor Alison Avenell

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Professor Alison Avenell
Professor Alison Avenell
Professor Alison Avenell

Clinical Chair in Health Services Research

51cg
Email Address
a.avenell@abdn.ac.uk
Telephone Number
+44 (0)1224 438164
Office Address

Health Services Research Unit
3rd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Alison Avenell joined the Unit in 1998, as a Clinical Research Fellow. She was subsequently funded by the Chief Scientist Office (CSO) of the Scottish Government Health Directorates as a Clinical Research Fellow to undertake research in the MRC funded RECORD trial, which examined the effect of calcium and/or vitamin D supplementation in the secondary prevention of osteoporotic fractures. She also led the MAVIS trial which examined the effectiveness of vitamin and mineral supplementation in preventing infections in older people, and helped lead the SIGNET trial of glutamine and selenium supplementation in critical illness. She was a CSO funded Career Scientist and currently has a clinical chair in health services research and is an Honorary Consultant in Clinical Biochemistry, undertaking systematic reviews and randomised controlled trials of treatments for adult obesity, and under-nutrition in clinical practice.

Research

Current Research

Current projects

Completed projects

Publications

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  • Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial

    Band, M. M., Sumukadas, D., Struthers, A. D., Avenell, A., Donnan, P. T., Kemp, P. R., Smith, K. T., Hume, C. L., Hapca, A., Witham, M. D.
    Trials, vol. 19, 6
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • New debate: is it time for infertility weight loss programmes to be couple-based?

    Best, D., Avenell, A., Bhattacharya, S., Stadler, G.
    Human Reproduction, vol. 32, no. 12, pp. 2359-2365
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease and cancer: a systematic review and meta-analysis

    Ma, C., Avenell, A., Bolland, M., Hudson, J., Stewart, F., Robertson, C., Sharma, P., Fraser, C., MacLennan, G.
    BMJ, vol. 359, j4849
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • How effective are weight-loss interventions for improving fertility in women and men who are overweight or obese?: A systematic review and meta-analysis of the evidence

    Best, D., Avenell, A., Bhattacharya, S.
    Human Reproduction Update, vol. 23, no. 6, pp. 681-705
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Weight loss interventions in specific groups: Overweight and obese men

    Avenell, A., Robertson, C., Archibald, D.
    Advanced Nutrition and Dietetics in Obesity. Wiley, pp. 228-234, 7 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
    • [ONLINE] DOI:
    • [ONLINE]

  • Reporting of conflicts of interest in oral presentations at medical conferences: a delegate-based prospective observational study

    Grey, A., Avenell, A., Dalbeth, N., Stewart, F., Bolland, M. J.
    BMJ Open, vol. 7, no. 9, e017019
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical Effectiveness of Weight Loss and Weight Maintenance Interventions for Men: A Systematic Review of Men-Only Randomized Controlled Trials (The ROMEO Project)

    Robertson, C., Avenell, A., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., Van Teijlingen, E., Boyers, D.
    American Journal of Men's Health, vol. 11, no. 4, pp. 1096-1123
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Letter to the Editor - Calcium Intake and Cardiovascular Disease Risk

    Reid, I. R., Avenell, A., Grey, A., Bolland, M. J.
    Annals of Internal Medicine, vol. 166, no. 9, pp. 684-685
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [ONLINE]

  • Do vitamin D supplements help prevent respiratory tract infections?

    Bolland, M. J., Avenell, A.
    British Medical Journal (Clinical Research Ed.), vol. 356, pp. j456
    Contributions to Journals: Editorials
    • [ONLINE] DOI:

  • Vitamin D supplements and disease prevention: Neglect or good practice? Authors' reply to letters by Rhein and Degner

    Bolland, M. J., Avenell, A., Grey, A.
    British Medical Journal (Clinical Research Ed.), vol. 356, pp. j716
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Further major uncorrected errors in National Osteoporosis Foundation meta-analyses of calcium and vitamin D supplementation in fracture prevention

    Avenell, A., Bolland, M. J., Grey, A., Reid, I. R.
    Osteoporosis International, vol. 28, no. 2, pp. 733-734
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Sex based differences in trials: Sex can affect participation, engagement, and adherence in trials

    Avenell, A., Robertson, C., Stewart, F., Boyers, D., Douglas, F., Archibald, D., van Teijlingen, E., Hoddinott, P., Boachie, C.
    BMJ, vol. 355, 6754
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Systematic review and statistical analysis of the integrity of 33 randomized controlled trials

    Bolland, M. J., Avenell, A., Gamble, G. D., Grey, A.
    Neurology, vol. 87, no. 23, pp. 2391-2402
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Nutritional supplementation for hip fracture aftercare in older people

    Avenell, A., Smith, T. O., Curtain, J. P., Mak, J. C., Myint, P. K.
    Cochrane Database of Systematic Reviews, no. 11, CD001880
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Should adults take vitamin D supplements to prevent disease?

    Bolland, M. J., Avenell, A., Grey, A.
    BMJ, vol. 355, i6201
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A randomised controlled trial comparing laparoscopic cholecystectomy with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones. (C-Gall trial)

    Malik, M., Murchie, P., Gillies, K., Brazzelli, M. G., Avenell, A., Hernandez, R., Norrie, J., Blazeby, J., Ramsay, C., Ahmed, I.
    International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland, pp. 195-196
    Contributions to Journals: Abstracts
    • [ONLINE] DOI:

  • Errors in NOF meta-analyses of calcium and vitamin D supplements

    Bolland, M. J., Avenell, A., Grey, A., Reid, I. R.
    Osteoporosis International, vol. 27, no. 8, pp. 2637-2639
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Patterns of weight change after the diagnosis of type 2 diabetes in Scotland and their relationship with glycaemic control, mortality and cardiovascular outcomes: a retrospective cohort study

    Aucott, L. S., Philip, S., Avenell, A., Afolabi, E. K., Sattar, N., Wild, S., Scottish Diabetes Research Network (SDRN) Epidemiology group
    BMJ Open, vol. 6, no. 7, pp. 1-14
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Behavioural Interventions for Severe Obesity Before and/or After Bariatric Surgery: a Systematic Review and Meta-analysis

    Stewart, F., Avenell, A.
    Obesity Surgery, vol. 26, no. 6, pp. 1203-1214
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Qualitative research, observational research, and The BMJ

    Bolland, M. J., Avenell, A., Grey, A.
    British Medical Journal (Clinical Research Ed.), vol. 352, pp. 1-1
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Should weight loss and maintenance programmes be designed differently for men? A systematic review of long-term randomised controlled trials presenting data for men and women: The ROMEO project

    Robertson, C., Avenell, A., Boachie, C., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D.
    Obesity research & clinical practice, vol. 10, no. 1, pp. 70-84
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A Qualitative Evidence Synthesis on the Management of Male Obesity

    Archibald, D., Douglas, F., Hoddinott, P., Van Teijlingen, E., Stewart, F., Robertson, C., Boyers, D., Avenell, A.
    BMJ Open, vol. 5, no. 10, e008372
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis

    Ball, R. J., Avenell, A., Aucott, L., Hanlon, P., Vickers, M. A.
    Arthritis Research & Therapy, vol. 17, pp. 274
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis (the BiCARB trial)?: Study protocol for a randomized controlled trial

    Witham, M. D., Band, M. M., Littleford, R. C., Avenell, A., Soiza, R. L., McMurdo, M. E. T., Sumukadas, D., Ogston, S. A., Lamb, E. J., Hampson, G., MacNamee, P., BiCARB Study Group
    Trials, vol. 16, 326
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Gaining pounds by losing pounds: preferences for lifestyle interventions to reduce obesity

    Ryan, M., Yi, D., Avenell, A., Douglas, F., Aucott, L., van Teijlingen, E., Vale, L.
    Health economics, policy, and law, vol. 10, no. 2, pp. 161-182
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Gaining pounds by losing pounds: HERU Policy Brief

    Ryan, M. E., Yi, D., Avenell, A., Douglas, F. C. G., Aucott, L. S., Van Teijlingen, E., Vale, L. D.
    Working Papers: Working Papers

  • Systematic review of the clinical and cost effectiveness of cholecystectomy versus observation/conservative management for uncomplicated symptomatic gallstones or cholecystitis

    Brazzelli, M., Cruickshank, M., Kilonzo, M., Ahmed, I., Stewart, F., McNamee, P., Elders, A., Fraser, C., Avenell, A., Ramsay, C.
    Surgical Endoscopy, vol. 29, no. 3, pp. 637-647
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Calcium supplements increase risk of myocardial infarction

    Bolland, M. J., Grey, A., Avenell, A., Reid, I. R.
    Journal of Bone and Mineral Research, vol. 30, no. 2, pp. 389-390
    Contributions to Journals: Letters
    • [ONLINE] DOI:

  • Branched-chain amino acid supplementation in adults with cirrhosis and porto-systemic encephalopathy: systematic review

    Metcalfe, E. L., Avenell, A., Fraser, A.
    Clinical Nutrition, vol. 33, no. 6, pp. 958-965
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis

    Ford, J. A., MacLennan, G. S., Avenell, A., Bolland, M., Grey, A., Witham, M., RECORD Trial Group
    The American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 746-755
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Clinical effectiveness and cost-effectiveness of cholecystectomy compared with observation/conservative management for preventing recurrent symptoms and complications in adults presenting with uncomplicated symptomatic gallstones or cholecystitis: a systematic review and economic evaluation

    Brazzelli, M., Cruickshank, M., Kilonzo, M., Ahmed, I., Stewart, F., McNamee, P., Elders, A., Fraser, C., Avenell, A., Ramsay, C.
    Health Technology Assessment, vol. 18, no. 55, pp. 1-102
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Are men difficult to find?: Identifying male-specific studies in MEDLINE and Embase

    Stewart, F., Fraser, C., Robertson, C., Avenell, A., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D.
    Systematic reviews , vol. 3, 78
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials

    Dombrowski, S. U., Knittle, K., Avenell, A., Araújo-Soares, V., Sniehotta, F. F.
    BMJ, vol. 348, g2646
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Systematic reviews of and integrated report on the quantitative, qualitative and economic evidence base for the management of obesity in men

    Robertson, C., Archibald, D., Avenell, A., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D., Stewart, F., Boachie, C., Fioratou, E., Wilkins, D., Street, T., Carroll, P., Fowler, C.
    Health Technology Assessment, vol. 18, no. 35, pp. v-vi, xxiii-xxix, 1-424
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men

    Avenell, A., Mak, J. C. S., O'Connell, D.
    Cochrane Database of Systematic Reviews, no. 4, CD000227
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Patterns of weight change in the first 5 years after diagnosis of Type 2 diabetes and their impact on glycaemic control and mortality

    Aucott, L., Philip, S., Avenell, A.
    Diabetic Medicine, vol. 31, no. s1, pp. 25-25
    Contributions to Journals: Abstracts

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus

    Hanlon, P., Avenell, A., Aucott, L., Vickers, M. A.
    Arthritis Research & Therapy, vol. 16, no. 1, R3
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Advance telephone calls ahead of reminder questionnaires increase response rate in non-responders compared to questionnaire reminders only: The RECORD phone trial

    Maclennan, G., McDonald, A., McPherson, G., Treweek, S., Avenell, A., RECORD Trial Group
    Trials, vol. 15, 13
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Calcium supplements and cancer risk: a meta-analysis of randomised controlled trials

    Bristow, S. M., Bolland, M. J., Maclennan, G. S., Avenell, A., Grey, A., Gamble, G. D., Reid, I. R.
    British Journal of Nutrition, vol. 110, no. 8, pp. 1384-1393
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • What is the appropriate MHRA regulatory response to calcium's increased cardiovascular risk?

    Bolland, M. J., Avenell, A., Grey, A., Reid, I. R.
    BMJ (Clinical research ed.), vol. 346, no. 7910, pp. 1-1
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [ONLINE]

  • Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis

    Almohmeed, Y. H., Avenell, A., Aucott, L., Vickers, M. A.
    PloS ONE, vol. 8, no. 4, e61110
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis

    Palmer, A. J., Ho, C. K. M., Ajibola, O., Avenell, A.
    Critical Care Medicine, vol. 41, no. 1, pp. 307-316
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials

    Rejnmark, L., Avenell, A., Masud, T., Anderson, F., Meyer, H. E., Sanders, K. M., Salovaara, K., Cooper, C., Smith, H. E., Jacobs, E. T., Torgerson, D., Jackson, R. D., Manson, J. E., Brixen, K., Mosekilde, L., Robbins, J. A., Francis, R. M., Abrahamsen, B.
    Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 8, pp. 2670-2681
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Nutritional support for liver disease

    Koretz, R. L., Avenell, A., Lipman, T. O.
    Cochrane Database of Systematic Reviews, no. 5, CD008344
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD trial)

    Avenell, A., Maclennan, G. S., Jenkinson, D. J., McPherson, G. C., McDonald, A. M., Pant, P. R., Grant, A. M., Campbell, M. K., Anderson, F. H., Cooper, C., Francis, R. M., Gillespie, W. J., Robinson, C. M., Torgerson, D. J., Wallace, W. A., RECORD Trial Group
    Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 614-622
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Identifying active ingredients in complex behavioural interventions for obese adults with obesity-related co-morbidities or additional risk factors for co-morbidities: a systematic review

    Dombrowski, S. U., Sniehotta, F., Avenell, A., Johnston, M., MacLennan, G. S., Araujo-Soares, V.
    Health Psychology Review, vol. 6, no. 1, pp. 7-32
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Lightening the load?: A systematic review of weight management interventions in the community pharmacy setting

    Gordon, J., Watson, M., Avenell, A.
    Obesity Reviews, vol. 12, no. 11, pp. 897-911
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Randomised controlled feasibility trial of an evidence-informed behavioural intervention for obese adults with additional risk factors

    Sniehotta, F. F., Dombrowski, S. U., Avenell, A., Johnston, M., McDonald, S., Murchie, P., Ramsay, C. R., Robertson, K., Araujo-Soares, V.
    PloS ONE, vol. 6, no. 8, e23040
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Calcium, vitamin D, and risk: Authors' reply

    Bolland, M. J., Avenell, A., Grey, A., Gamble, G. D., Reid, I. R.
    BMJ, vol. 342, no. 7810, d3544
    Contributions to Journals: Letters
    • [ONLINE] DOI:
    • [ONLINE]

  • Cardiovascular effects of calcium supplementation

    Reid, I. R., Bolland, M. J., Avenell, A., Grey, A.
    Osteoporosis International, vol. 22, no. 6, pp. 1649-1658
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:
    • [OPEN ACCESS]
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