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Dr Ian Fleming

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Dr Ian Fleming
Dr Ian Fleming
Dr Ian Fleming

Senior Lecturer

51cg
Email Address
i.n.fleming@abdn.ac.uk
Telephone Number
+44 (0)1224 438357
Office Address

Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK

School/Department
School of Medicine, Medical Sciences and Nutrition


Research

Research Overview

Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.

Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.

Current Research

Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis. 

Collaborations

Prof Fiona Gilbert, University of Cambridge

Prof Paula Ghaneh, University of Liverpool

Prof David O'Hagan, University of St Andrews

Kemotech, Italy

 

  

Funding and Grants

Current Grants:

Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)

18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)

Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)

Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)   

Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)

Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)  

Teaching

Teaching Responsibilities

Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills

Programme coordinator BT5007: Industrial Placement/MSci course

Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease

Course coordinator & lecturer BP5003: Biomedical and other Professional Topics

Lecturer SM2501: Research skills for Medical Sciences

Coordinator of Hotstart programme   

Publications

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  • Clinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer

    Alwadani, B., Dall'Angelo, S., Fleming, I.
    Insights into Imaging, vol. 12, no. 1, 90
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Synthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR

    Musolino, M., Fleming, I. N., Schweiger, L. F., O'hagan, D., Dall'Angelo, S., Zanda, M.
    European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

    Hernandez Gerez, E., Dall'angelo, S., Collinson, J. M., Fleming, I. N., Parson, S. H.
    Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Hypoxia PET/CT and Colorectal Cancer: A Case Report

    Laws, K., Murray, G. I., Kerr, K., McKiddie, F., Dall'angelo, S., Zanda, M., Fleming, I., Samuel, L.
    Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A role for spinal cord hypoxia in neurodegeneration

    Hernandez Gerez, E., Fleming, I. N., Parson, S. H.
    Cell Death & Disease, vol. 10, 861
    Contributions to Journals: Review articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

    Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M., O'Hagan, D.
    Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [ONLINE]

  • Two Years On: How the Core Curriculum has Shaped Pharmacology Courses at the 51cg

    Tucker, S., Fleming, I. N., Hislop, J. N., Murray, F., Scott, D. A., Wallace, H. M.
    Contributions to Specialist Publications: Featured Articles
    • [ONLINE]

  • Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status

    Andriu, A., Crockett, J., Dall'Angelo, S., Piras, M., Zanda, M., Fleming, I. N.
    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin

    Piras, M., Testa, A., Fleming, I. N., Dall'Angelo, S., Andriu, A., Menta, S., Mori, M., Brown, G. D., Forster, D., Williams, K. J., Zanda, M.
    ChemMedChem, vol. 12, no. 14, pp. 1142-1151
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

    Lazzari, P., Spiga, M., Sani, M., Zanda, M., Fleming, I. N.
    Hypoxia, vol. 5, pp. 45-59
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Design and synthesis of an RGD peptidomimetic-paclitaxel conjugate targeting αvβ3 integrin for tumour-directed drug delivery

    Piras, M., Andriu, A., Testa, A., Wienecke, P., Fleming, I. N., Zanda, M.
    Synlett, vol. 28, no. 20, pp. 2769-2776
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3

    Phyu, S. M., Tseng, C. T., Fleming, I. N., Smith, T. A. D.
    Scientific Reports, vol. 6, 36544
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

    Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

    Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M., Piras, M.
    Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase

    Thompson, S., Fleming, I. N., O’Hagan, D.
    Organic & Biomolecular Chemistry, vol. 14, no. 11, pp. 3120-3129
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Changes in [18F]Fluoro-2-deoxy-D-glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling

    Cooper, A. C., Fleming, I. N., Phyu, S. M., Smith, T. A. D.
    Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1523-1532
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • The tubulysin analogue KEMTUB10 induces apoptosis in breast cancer cells via p53, Bim and Bcl-2

    Lamidi, O., Sani, M., Lazzari, P., Zanda, M., Fleming, I. N.
    Journal of Cancer Research and Clinical Oncology, vol. 141, no. 9, pp. 1575-1583
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Imaging tumour hypoxia with Positron Emission Tomography

    Fleming, I. N., Manavaki, R., Blower, P. J., West, C., Williams, K. J., Harris, A. L., Domarkas, J., Lord, S., Baldry, C., Gilbert, F. J.
    British Journal of Cancer, vol. 112, no. 2, pp. 238-250
    Contributions to Journals: Literature Reviews
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • A two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomography

    Thompson, S., Onega, M., Ashworth, S., Fleming, I. N., Passchier, J., O'Hagan, D.
    Chemical Communications, vol. 51, no. 70, pp. 13542-13545
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

    Nortcliffe, A., Fleming, I. N., Botting, N. P., O'Hagan, D.
    Tetrahedron, vol. 70, no. 44, pp. 8343-8347
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions

    Thompson, S., Zhang, Q., Onega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, J. H., Passchier, J., O'Hagan, D.
    Angewandte Chemie International Edition, vol. 53, no. 34, pp. 8913-8918
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [ONLINE]

  • Early changes in [18F] FDG incorporation by breast cancer cells treated with trastuzumab in normoxic conditions: Role of the Akt-pathway, glucose transport and HIF-1α

    Fleming, I. N., Andriu, A., Smith, T. A. D.
    Breast Cancer Research and Treatment, vol. 144, no. 4, pp. 241-248
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]
    • [OPEN ACCESS]

  • Multifunctional Deuterated and Tritiated “Click” Molecular Probes via Pd-mediated Reductive De-iodination of 5-Iodo-1,2,3-Triazoles

    Testa, A., Piras, M., Hickey, M. J., Fleming, I. N., Bushby, N., Lenz, E., Elmore, C. S., Zanda, M.
    Synlett, vol. 25, no. 07, pp. 1019-1025
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

    Bain, G. H., Collie-Duguid, E., Murray, G. I., Gilbert, F. J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H. I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Matula, K. M., Petty, R. D.
    British Journal of Cancer, vol. 110, no. 6, pp. 1525-1534
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Hypoxia stimulates 18F-Fluorodeoxyglucose uptake in breast cancer cells via hypoxia inducible factor-1 and AMP-activated protein kinase

    Smith, T. A. D., Zanda, M., Fleming, I. N.
    Nuclear Medicine and Biology, vol. 40, no. 6, pp. 858-864
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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